DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and Epb41l1

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_067713.2	Gene:	Epb41l1 / 59317	RGDID:	71087	Length:	1551	Species:	Rattus norvegicus

Alignment Length:	1872	Identity:	486/1872 - (25%)
Similarity:	718/1872 - (38%)	Gaps:	594/1872 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AEPETPTKS-KPKSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFG 74
            :|..||:|: |.....:...|.|..||||||.|..:..:::...|:.:.:.:|..|||:||||||
  Rat    75 SERTTPSKAQKSPQKIAKKFKSATCRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFG 139

  Fly    75 LTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGR 139
            ||:......:.|||..|.:.|..|:..|...|.||||||:|:||.||||||:||||:|.||:.||
  Rat   140 LTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGR 204

  Fly   140 LPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAE 204
            |||:||||||||||.||:|:||:|.|| ....|:.:.:.|||||.|||:::|:||||::|.:|.|
  Rat   205 LPCSFVTHALLGSYAVQAELGDHDTEE-HVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGE 268

  Fly   205 AELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHH 269
            ||:|:|||||||:|||||||.||||||:||||||||:|||:|||:||||||||||||||||||.:
  Rat   269 AEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSN 333

  Fly   270 FYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYK 334
            |||||||||:||:||||||||.|||:||:|||.|:||||||||::|||..|.  |.|.||.:||.
  Rat   334 FYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKG--FLVMGSKFRYS 396

  Fly   335 GRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLD--HRGDRNADG 395
            |||||::  .:..:||..|.|.|:.|.....|||:|.   ||..:.|..|...|  ..||:..|
  Rat   397 GRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDG---AEFSRPASVSENHDAGPDGDKRED- 457

  Fly   396 DAHS------------RSPIKNK------------KEKDADK--------EAKLREKKQKEKEEK 428
            ||.|            |:|.|.|            |::..||        :|.:.|.|:..||..
  Rat   458 DAESGGRRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPN 522

  Fly   429 ERK-------EREKR---------------ELEEKKKAEKAAKAALAAGAAAG----------AA 461
            .:.       |||:|               :..|.::.:..::..|..|.|.|          |:
  Rat   523 SKLIHRDRDWERERRLPSSPASPSPKGTPEKASEAQRIQDTSRQDLVPGTATGLEMFTQKSLAAS 587

  Fly   462 VNGNDE----------------LNDSNKSDKSSGRRGVGIFSSGRKSK----------------- 493
            ..|::.                |..:....|.||....||.:.||.||
  Rat   588 PEGSEHWVFIERVYTRPEDLGLLTVAATQRKESGSSLSGILADGRLSKVDILVDKFKVEVATEET 652

  Fly   494 ----SGSPSKDGK-------DKSGKDKDKEVGRLGLVVTSGLGDNQQDQNLDEAARNAAKNRGST 547
                ..|..:.||       .::.:::|:          .|.|:......|.|.:|...:|.|.:
  Rat   653 VRTRRTSTQQQGKMLASPEDFETVREEDR----------GGPGEATSTDKLPEGSRLKLRNHGVS 707

  Fly   548 TPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQDPNSRKSGADGQEQLSPTSQQKKIGLAFNYA 612
            ...:..|.|:.::         :..|.|      .|.:...|....|.|||||.:
  Rat   708 NGQLESQVEWGLE---------RPQTWG------RPTAAGLGPVQGEVLSPTSDK---------- 747

  Fly   613 PGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLLQDPLLSPTTRAKLQ--------GS 669
            .|.::.|.:.|:.......|..|...............|..:|.||:|.:..:.:        |:
  Rat   748 GGLQSFLLDPAQAEARADSSDETDTSFAERSFCLHYGEKDSEDQLLAPPSEHREEHPDALPGDGT 812

  Fly   670 AVDAAAVPLSDSQKRSYSPTKGPQGYSSGAPGSYKPISDPTADFLESQRYNKEP-----GYVGPS 729
            .::.|.|...:.:.:|..|.....|.|.....::|.   |:|:...:.|.:..|     ..||.:
  Rat   813 WLELAGVHTENWELKSSDPRASAPGSSQHKDQAHKA---PSAEEAWTPRDHGRPDDPQGAAVGQT 874

  Fly   730 ------------KADVAAGLAGAA-----------GSKKPGSPTKTGKGAPGAAAAAAAGAAGAA 771
                        :.::...||..|           |..:...|.:..|..||........|...|
  Rat   875 FEEVWENTQQRLEGELVQPLASVAEDEVPTNMDWMGKTEKSPPARRKKSPPGRGGGVHLDAQACA 939

  Fly   772 AAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTLEAL 836
            .....|...|.........|.|.      |.|::  |...::|.|           ..:.|:..|
  Rat   940 LLRTIPPCVRKPARPDQGSFLPK------EKGTV--SPPAVEPET-----------EDRETVSPL 985

  Fly   837 NTKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGR--LDDTLGQIV--CITPQDNPVVELTVITSR 897
            ...:|..||... ::| |....|..|...|...|  ..|....::  ...|:::||.:
  Rat   986 PVSSGHTEVLAA-MEG-TSLSPLPPGSRGPSESREFFRDQFPVVLKYIHLPEESPVPK------- 1041

  Fly   898 IDPATGKIDTVNGDVERSLGVLNLDTGLLDTKYGEINTRTGELKAIDPKSGKIVVSKNVKVDP-G 961
             ||        :||                                  :....|.||..:..| |
  Rat  1042 -DP--------HGD----------------------------------RKAPPVASKKPRFVPEG 1063

  Fly   962 TGQITILG-IVDP----KTNKIDPNQGRLIEVGQQIDPIVEVTSLAGKFDSKRNIIDPKTAQVET 1021
            :.:..:|| ::.|    :|:..|.:||                      ||:.:|
  Rat  1064 SEEPVLLGELMFPSGKQETSLQDWDQG----------------------DSQEDI---------- 1096

  Fly  1022 SGGQFDPKAGKIDTKYGQIDLVKHTITFNDPKSGKTVTRDIKIEPTTGQIVLKNQVNPKNNKPDK 1086
                                            |..:|...|:|..|.|....:.......:.|.:
  Rat  1097 --------------------------------SKTSVANKIRIFETHGAEACRASQGEMRSLPHE 1129

  Fly  1087 DYARIISLRIVQQRVDPATKAPITEVSASKDKDIVVDPKSNQIWVPTGATDPATKEQQYISSSVD 1151
                                                        :|:||: |...|||
  Rat  1130 --------------------------------------------LPSGAS-PGQVEQQ------- 1142

  Fly  1152 PKTGYVITIYGYLDPKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGEPLYAATQVDPES 1216
                                  ...||...::::|........|...::.|...|     |.|:|
  Rat  1143 ----------------------DNLLDLGFVQLQPPGDLATPTTYHQERCTDPEL-----VSPDS 1180

  Fly  1217 GEVYTKLARVDPKTGKIVIVRILLISKTDERGRPEE-----IDPSTCEIDPVSGRVLKFFNKTVY 1276
            |...|    ::..||          ||:.:.||.::     :.|:|    |..|..|:|
  Rat  1181 GCETT----LEEATG----------SKSGDAGREDKSSFRRLAPNT----PGKGGRLRF------ 1221

  Fly  1277 VYNMIDPVTGEIVQVDPNDPRFAGARTTVTHTMTLTGEIDPVTGRIKSEYGDIDPNTGDIDPATA 1341
                          ..|..|:.||.|.....      ::.|...|..      :.:|||.|
  Rat  1222 --------------ASPPGPQRAGLREGSEE------KVKPPRPRAP------ESDTGDED---- 1256

  Fly  1342 VTDPVTGKLIL--NYAQIDPSHFGKQAQVQTTTETVPITRQQFFDGVKHISKGA----------L 1394
             .|.....:.|  |:..|:     ::....|.:.|..:..:..|..:.....||          |
  Rat  1257 -QDQERDAVFLKDNHLAIE-----RKCSSITVSSTSSLEAEVDFTVIGDYHGGAFEDFSRSLPEL 1315

  Fly  1395 RRDSEGSSDDDMTAQYGADQVNEILIGSPAGQ---AGGKLGKP----VSTPTVVKTTTKQVLTKN 1452
            .||...|..:.:.  :..|      :..|:.|   :||....|    .|||.:.:..:.:..|..
  Rat  1316 DRDKSDSETEGLV--FARD------LKGPSSQEDESGGIEDSPDRGACSTPELPQFESVKAETMT 1372

  Fly  1453 IDGVTHNVEEEVRNLGTGEVTYSTQEHKADATPTDLSGAYVTATAVTTRTATTHEDLGKNAKTEQ 1517
            :..:.      :|.....|....::...||:|..| .||......:||....|.|
  Rat  1373 VSSLA------IRKKIEPEAMLQSRVSTADSTQVD-GGAPAAKDFMTTPPCITTE---------- 1420

  Fly  1518 LEEKTVATTRTHDPNKQQQRVVTQEVKTTATVTSGDQYQRRDSVSSTSSGDSGTPIDGPYDGASV 1582
                |::||..:                                |..|...:...|.||...|:.
  Rat  1421 ----TISTTMEN--------------------------------SLKSGKGAAAMIPGPQTVATE 1449

  Fly  1583 VRTDNQKSPLFTTSATTGPHVESTRVVLGED--TPGFSGHGEIISTQTVSSKTRTVETITYKTER 1645
            :|:   .||                 ::|:|  |..:....|.:||.|.:..|:||        :
  Rat  1450 IRS---LSP-----------------IIGKDVLTSTYGATAETLSTSTTTHVTKTV--------K 1486

  Fly  1646 DGIVETRVEQKITIQSDGDPIDHDKALAEAIQEATAMNPDMTVEKIEIQQQT 1697
            .|..|||:|::|.|..|.| :|.|:|||.||:||...:|||.|.|..:.::|
  Rat  1487 GGFSETRIEKRIIITGDED-VDQDQALALAIKEAKLQHPDMLVTKAVVYRET 1537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	105/189 (56%)
		FERM_N	36..98	CDD:286467	24/61 (39%)
		FERM_M	116..224	CDD:278785	70/107 (65%)
		FERM_C_4_1_family	219..312	CDD:270005	78/92 (85%)
		FA	323..363	CDD:285894	17/41 (41%)
		PQQ_2	829..>972	CDD:290097	26/148 (18%)
		4_1_CTD	1612..1698	CDD:283537	33/88 (38%)
Epb41l1	NP_067713.2	B41	98..288	CDD:214604	105/190 (55%)
		FERM_C_4_1_family	283..376	CDD:270005	78/92 (85%)
		FA	385..428	CDD:400882	17/44 (39%)
		SAB	493..>524	CDD:398195	8/30 (27%)
		4_1_CTD	1414..1538	CDD:399118	48/199 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345158
Domainoid	1	1.000	168	1.000	Domainoid score	I3725
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm45774
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740