DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and EPB41L4B

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_011517092.1	Gene:	EPB41L4B / 54566	HGNCID:	19818	Length:	941	Species:	Homo sapiens

Alignment Length:	837	Identity:	215/837 - (25%)
Similarity:	325/837 - (38%)	Gaps:	210/837 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PSAPAEPETPTKSKP--------KSSSSSHGKPAL-ARVTLLDGSLLDVSIDRKAIGRDVINSIC 62
            |:||.....|....|        ..|::...|..| .||.||||:.:.|.:.:.|.|:|:.:.|.
Human    51 PAAPGGSVFPAGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIV 115

  Fly    63 AGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSKFFRT-DTWPLTFAVKFYPPEPSQLKEDITRYH 126
            ..|:|:|.|||||.:........|||..||:.|..:. ..:.|.|.||:|..||:.|:|:.|||.
Human   116 YHLDLVETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYL 180

  Fly   127 LCLQVRNDILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVM 191
            ..||:|:|||.|:|.|.:.|...|.:..:|:|:|:.:..| .|...:.:|:..||||..:|..:.
Human   181 FVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPE-HTPELVSEFRFIPNQTEAMEFDIF 244

  Fly   192 DLHKTHKGQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFA 256
            ...|..:|:|||:|||.||..||.|.|||||:|..:..:|.:..||:..:|:|::....:|..|.
Human   245 QRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFF 309

  Fly   257 WPKILKISYKRHHFYIKIRPGEFE--QYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVS 319
            ||||.|:.:|:....:.:...:.:  :.|.|..|:|.:.|..|.|||..||||.||||.||.. |
Human   310 WPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGN-S 373

  Fly   320 KSKM--FPVFGSTYRYKGRTQAESTNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKS 382
            ||..  |...||.:|:.|||:.::|:               |:||                 |::
Human   374 KSNRSDFIRLGSRFRFSGRTEYQATH---------------GSRL-----------------RRT 406

  Fly   383 STLDHRGDRNADGDAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKA 447
            ||.:.:..:......||     ..|..:....|:|..|...|....:.:........:.:....:
Human   407 STFERKPSKRYPSRRHS-----TFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHS 466

  Fly   448 AKAALAAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKE 512
            ...:....:...:                ||.|...||..:|     |:|.
Human   467 PNVSYPLPSPVLS----------------SSDRLPFGIEENG-----GTPF-------------- 496

  Fly   513 VGRLGLVVTSGLGDNQ-QDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGG 576
                 |...||...:| |.|:..:...|               |..::..:....|.|
Human   497 -----LTAASGRHHHQHQHQHQHQHHSN---------------YSLSLTLENKEGPLR------- 534

  Fly   577 FRYDQDPNSRKSGADGQEQLSPTSQQKKIGLAFNYAPGNENALKETAEKLKAGQLS--------P 633
                                ||.|..|.:   ...:||......|.|..||..:|.        |
Human   535 --------------------SPNSSSKSL---TKLSPGTPALFSEAAAHLKKLELETVKAAGPWP 576

  Fly   634 RTQDKLNRGQLSPKSRAKLLQDPLL-SP----------------TTRAKLQGSAVDAAAV----- 676
            .....:|:.: ..|...|.||.||| ||                .:|..:||...::..|
Human   577 PLHININKAE-EKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVNIQGGKEESPFVNINKK 640

  Fly   677 -PLSDSQKRSYSPTKGPQGYSSGAPGSYKP-ISDPTADFLESQ-RYNKEPGYVGPSKADVAAGLA 738
             .|.|:..||..|.:    ..:..|...|| |..|....|..| .:|:.      .:.|:...||
Human   641 SSLQDASVRSPIPIR----VETAQPAVEKPEIKPPRVRKLTRQYSFNRS------DEDDLPPDLA 695

  Fly   739 GAAG------------------------SKKPGSPTKT-GKG--APGAAAAAAAGAA 768
            .|.|                        .:...||.|: |||  :|||.:.:..|.|
Human   696 EAVGVTTSTTTNTTTAATQVSVPLPSPKVQNVSSPHKSEGKGLLSPGAKSPSDRGGA 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	77/190 (41%)
		FERM_N	36..98	CDD:286467	24/61 (39%)
		FERM_M	116..224	CDD:278785	45/107 (42%)
		FERM_C_4_1_family	219..312	CDD:270005	33/94 (35%)
		FA	323..363	CDD:285894	10/41 (24%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
EPB41L4B	XP_011517092.1	B41	87..277	CDD:214604	77/190 (41%)
		FERM_N	89..151	CDD:286467	24/61 (39%)
		FERM_M	170..277	CDD:278785	45/107 (42%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	31/92 (34%)
		FA	379..419	CDD:285894	14/71 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151641
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740