DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and epb41l3a

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_021325820.1	Gene:	epb41l3a / 445478	ZFINID:	ZDB-GENE-040822-8	Length:	1177	Species:	Danio rerio

Alignment Length:	1733	Identity:	417/1733 - (24%)
Similarity:	623/1733 - (35%)	Gaps:	691/1733 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TPTK--SKPKSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTY 77
            :|.|  .|||:..        .::||||||.....::::..|:.:.:.:|..|||:||||||:|:
Zfish    79 SPAKISKKPKNMQ--------CKITLLDGSDYTCVVEKRDKGQVLFDKVCEHLNLLEKDYFGITF 135

  Fly    78 ETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPC 142
            ....:.:.|||..|.:.|..|...|..:|.||||||||:.|.||||||:||||:|:||..|||||
Zfish   136 RDVENQKNWLDPAKDMKKQIRGVAWNFSFNVKFYPPEPALLSEDITRYYLCLQLRDDISSGRLPC 200

  Fly   143 TFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAEL 207
            :|.||.:||||.||||:||:|.||..:. |..:|:.||.||.|:|:|::||||.:||.:|||||:
Zfish   201 SFATHTVLGSYTVQSELGDHDPEECGSE-YTSEFRFAPQQTKEMEEKIIDLHKNYKGMTPAEAEM 264

  Fly   208 HYLENAKKLAMYGVDLHPAK---------------DSEGVDIMLGVCASGLLVYRDKLRINRFAW 257
            |:|||.|||:|||||||.||               |||||:||||||:||||:|||:||||||||
Zfish   265 HFLENVKKLSMYGVDLHHAKLIGRFFHCFSPAKGEDSEGVEIMLGVCSSGLLIYRDRLRINRFAW 329

  Fly   258 PKILKISYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSK 322
            ||:|||||||::||||||||||||:||||||||.||||||:|||.||||||||||:.||  :..|
Zfish   330 PKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLVLPE--TPPK 392

  Fly   323 MFPVFGSTYRYKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMD---ALALAEKEKVARKS 382
            .|...||.:||.|||||::  .::.:.|..|.|.|:.|.....|||:|   ..||....|....|
Zfish   393 KFLTLGSKFRYSGRTQAQTRRASSQIVRPAPYFQRSSSKRYTMSRSLDGEMGTALYGAAKGIAMS 457

  Fly   383 STLDHRGDRNADGDAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKERE-KRELEEKKKAEK 446
            ..:                       .....|.|:.|:.|.:|.....|:.: :.|.|.:.....
Zfish   458 DLI-----------------------TTVTPEKKVEEEPQPQKHTHADKQMQPQTETETETDTHT 499

  Fly   447 AAKAALAAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDK 511
            ..:..|......         |.|.:::
Zfish   500 QTQTVLVENVMI---------LEDDDET------------------------------------- 518

  Fly   512 EVGRLGLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGG 576
                                                    ||..|.::     .||.    ||.
Zfish   519 ----------------------------------------TRATELSL-----PSPA----TPA- 533

  Fly   577 FRYDQDPNSRKSGADGQEQLSPTSQQKKIGLAFNYAPGNENALKETAEKLKAGQLSPRTQDKLNR 641
             |.|...:...:..||:...:.:.|:                 .|:..|.|...|:|   |:
Zfish   534 -RLDTRTDLTDTAVDGELTATESDQE-----------------DESEAKTKEADLTP---DE--- 574

  Fly   642 GQLSPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVPLSDSQKR-SYSPTKGPQGYSSGAPGSYKP 705
             ||.|::.        :|...|..|:|.|..|.   |::.:|| |.||.:.|:
Zfish   575 -QLKPQTN--------ISELKRTFLEGGAEPAG---LTEWEKRLSSSPLRSPR------------ 615

  Fly   706 ISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAAAAAAAGAAGA 770
                          .:||..:.|.:.|..
Zfish   616 --------------REEPPMIEPLELDEI------------------------------------ 630

  Fly   771 AAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTLEA 835
                    |:.|   |:.::....|:.:.|                                  |
Zfish   631 --------KQEV---VVETQEVAETQEVAA----------------------------------A 650

  Fly   836 LNTKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGRLDDTLGQIVCITPQDNPVVELTVITSRIDP 900
            |:|:...::|.: :.||                                       .||.:::.|
Zfish   651 LDTQENNRKVDE-ESDG---------------------------------------WVIINKVPP 675

  Fly   901 ATGKIDTVNGDVERSLGVLNLDTGLLDTKYGEINTRTGELKAIDPKSGKIVVSKNVKVDPGTGQI 965
                                     .:.....:.||  :..:|.|   :|:|.
Zfish   676 -------------------------FEAHKAPVETR--DKSSIQP---EIIVQ------------ 698

  Fly   966 TILGIVDPKTNKIDPNQGRLIEVGQQIDPIVEVTSLAGKFDSKRNIIDPKTAQVETSGGQFDPKA 1030
                                 :.....:|:.|...     |.....:||:    :|:..:..|:.
Zfish   699 ---------------------DASPPAEPMKEFPE-----DVPAEKMDPE----KTTKDEAPPEK 733

  Fly  1031 GKIDTKYGQIDLVKHTITFNDPKSGKTVTRDIKIEPTTGQIVLKNQVNPKNNKPDKDYARIISLR 1095
            ..::      :.:....|.::....||...:..:|.|
Zfish   734 TTVE------EALPEKTTVDEALPEKTTVDETPLEKT---------------------------- 764

  Fly  1096 IVQQRVDPATKAPITEVSASKDKDI--VVDPKSNQIWVPTGATDPATKEQQYISSSVDPKTGYVI 1158
            |.:..||   :.|..::.:.|.:|:  .|.||     ||     |...|:::.||
Zfish   765 IEKTTVD---ETPPEKIHSEKTEDVPPKVPPK-----VP-----PKVPEKKHSSS---------- 806

  Fly  1159 TIYGYLDPKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGEPLYAATQVDPESGEVYTKL 1223
              |.:|...::.        |....:.|.|                       .|..:|.:...|
Zfish   807 --YRFLSSMSSA--------PPPSSVRPRS-----------------------EDLSAGRISPAL 838

  Fly  1224 ARVDPKTGKIVIVRILLISKTDERGRPEEIDPSTCEIDPVSGRVLKFFNKTVYVYNMIDPVTGEI 1288
            .|..| |.|:                |:   ||..|:.|....:|:.......|.....|.....
Zfish   839 LRTSP-TAKV----------------PK---PSFEEMSPELTALLQSARSWTPVPASASPSASAS 883

  Fly  1289 VQVDP-----NDPRFAGARTTVTHT-MTLTGEIDPVTGRIKSEY------GDIDPNTGDIDPATA 1341
            ..|.|     :.|:...:.:...|. ..||.|..|....:....      |.::|: |......|
Zfish   884 ALVTPAPAALHTPQNQPSESVDEHLGKGLTEEERPADEPLDKPQVPAPPAGPLEPD-GYYQACVA 947

  Fly  1342 VTDPVTGKLILNYAQIDPSHFGKQAQVQTTTETVPITRQQFFDGVKHISKGALRRDSEGSS---- 1402
            ..:|::....|:.::.| ......:.|.:|....|:.|.     ....::.....:|||.|
Zfish   948 CVEPLSSVRALDESESD-GDSSDSSSVNSTNLDGPLERV-----APQRAESPSESESEGESFTLS 1006

  Fly  1403 ----DDDMTAQYGADQVNEILIGSPAGQAGGKLGKPVSTPTVVKTTTKQVLT-KNIDGVTHNVEE 1462
                |||      .|:...|.:....|.|.|..|: |.....|:|   .||: :::.|.||:
Zfish  1007 TDDEDDD------GDRSPNISLSEQRGVAEGHSGE-VDLMAGVET---GVLSFRSVSGDTHD--- 1058

  Fly  1463 EVRNLGTGEVTYSTQEHKADATPTDLSGAYVTATAVTTRTATTHEDLGKNAKTEQLEEKTVATTR 1527
                                                      |||
Zfish  1059 ------------------------------------------THE-------------------- 1061

  Fly  1528 THDPNKQQQRVVTQEVKTTATVTSGDQYQRRDSVSSTSSGDSGTPIDGPYDGASVVRTDNQKSPL 1592
            |||     ..|:..|:||.
Zfish  1062 THD-----TPVIQTEIKTI---------------------------------------------- 1075

  Fly  1593 FTTSATTGPHVESTRVVLGEDTPGFSGHGEIISTQTVSSKTRTVETITY--KTERDGIVETRVEQ 1655
                         |...|..:|.|.:..|.::|.||::|:|.:..|.|:  ||.:.||.|||:|:
Zfish  1076 -------------TYEALQAETDGDADPGVLMSAQTITSETTSTTTTTHITKTVKGGISETRIEK 1127

  Fly  1656 KITIQSDGDPIDHDKALAEAIQEATAMNPDMTVEKIEIQQQTQ 1698
            :|.|..|.| ||||:|||:||:||...:|||:|.|:.:.::|:
Zfish  1128 RIVISGDAD-IDHDEALAQAIKEAKEQHPDMSVTKVVVHKETE 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	101/189 (53%)
		FERM_N	36..98	CDD:286467	23/61 (38%)
		FERM_M	116..224	CDD:278785	67/107 (63%)
		FERM_C_4_1_family	219..312	CDD:270005	80/107 (75%)
		FA	323..363	CDD:285894	15/41 (37%)
		PQQ_2	829..>972	CDD:290097	15/142 (11%)
		4_1_CTD	1612..1698	CDD:283537	38/87 (44%)
epb41l3a	XP_021325820.1	B41	92..281	CDD:214604	101/189 (53%)
		FERM_C_4_1_family	276..384	CDD:270005	80/107 (75%)
		FA	393..434	CDD:312314	15/40 (38%)
		SAB	564..610	CDD:309500	18/63 (29%)
		DNA_pol3_delta2	<604..>780	CDD:331068	46/431 (11%)
		4_1_CTD	1064..1169	CDD:310467	45/169 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586182
Domainoid	1	1.000	166	1.000	Domainoid score	I3826
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1314
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm26068
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.750