DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and yrt

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_650291.1	Gene:	yrt / 41656	FlyBaseID:	FBgn0004049	Length:	972	Species:	Drosophila melanogaster

Alignment Length:	1056	Identity:	265/1056 - (25%)
Similarity:	389/1056 - (36%)	Gaps:	303/1056 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SSSSSHGKPAL---------ARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYE 78
            |..||..||..         .||.|||.:.|.:.:.:||:|..:...:...|::||||||||.:.
  Fly    40 SGGSSQIKPQRIVVNKNKIDCRVILLDNTDLSIELSKKALGSFLYEQVFYALDIIEKDYFGLQFM 104

  Fly    79 TPTDPRTWLDLEKPVSKFFRTDTWPLTF--AVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLP 141
            .....:.|||..||:.|..:... |.||  .||||..||:.|:|::|||...||::.|:|||||.
  Fly   105 DANHVKHWLDPTKPIKKQVKIGP-PYTFRLKVKFYSSEPNTLREELTRYLFFLQLKQDLLEGRLD 168

  Fly   142 CTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAE 206
            |.......|.:..:|||:||||.:| .:.|.:.:|:..|.||.:||..::|.:||.:|.:||:||
  Fly   169 CPEDKATELCALALQSELGDYDNQE-HSAATVSEFRFVPEQTEDLEIAILDEYKTCRGLTPAQAE 232

  Fly   207 LHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFY 271
            ..:|..||.|.|||||:|.....:|.:..||:..:|:||:....:|..|.||||.|:.:|:....
  Fly   233 TAFLNKAKWLDMYGVDMHTVLGKDGCEYHLGLTPTGILVFERDQKIGLFFWPKISKLDFKKKKLT 297

  Fly   272 IKIRPGEFE--QYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTP--EPVSKSKMFPVFGSTYR 332
            :.:...:.|  :.|.|..|:|.|.:|.|.|||..|||||||||..|  .|.::...|.: ||.:|
  Fly   298 LIVIEDDDEGREQEHTFVFRLYNEKACKHLWKCAVEHHTFFRLRAPVKGPSARQNFFRM-GSRFR 361

  Fly   333 YKGRTQAESTNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADGDA 397
            |.|||:.::|.....|...:|.|..| .|..||....|
  Fly   362 YSGRTEFQTTQQSRARRTVQFERRPS-QRFASRQSHLL--------------------------- 398

  Fly   398 HSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALAAGAAAGAA- 461
                                             :||:|...|....|..:..|..||.|||.||
  Fly   399 ---------------------------------RERQKASQEAAVSAVASVNARAAAAAAAAAAS 430

  Fly   462 -----------------VNGNDELNDS-----------------------------------NKS 474
                             ...||..||:                                   :.|
  Fly   431 QSPAPATPLVSSQVSTPTPNNDNNNDAFDSLISTDQFITVTPSPSVLTVIQNSAIIEPDAACSGS 495

  Fly   475 DKSSGRRGVGIFSSGRKS-KSGSPSKD---------GKDKSG------------------KDKDK 511
            ..||.:......|.||.| ||...::|         || .||                  |:.|:
  Fly   496 ISSSSQAAANFASLGRNSLKSNFSNEDPAYSKIGSIGK-ASGLTVKLDPDYTPPYSPNATKNFDE 559

  Fly   512 ----------EVGRLG--------LVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYA 558
                      ..|..|        |.|.|||.|  :|:.||...::..|:   .:|.|...   .
  Fly   560 TNPFRNATSSHHGSFGKASISSGQLSVKSGLSD--KDRELDSLLKSIVKD---PSPSVLAN---E 616

  Fly   559 VDNDGNTSPTRKSYTPGGFRYDQDPNS----RKSGADGQEQLSPTSQQKKIGL-AFNYAPGNE-- 616
            ..||.|:.....:.|     :|.|.|:    |.|.|:.:    |.:|.|...: .....|||.
  Fly   617 AINDANSIRVTINKT-----FDMDHNTETLKRLSNANEK----PNNQVKLANVNTTALPPGNIKC 672

  Fly   617 NALK-ETAEKLKAGQLSPRTQ-----------------------------DKLNRGQLSPKSRAK 651
            |.|| ...|:|.||..:..|.                             |.||...:|......
  Fly   673 NILKARVEEELGAGGNAKLTNQMFVPAAHSSNMHTSNTNSSNNHAHSDGPDSLNATYISVGGDKL 737

  Fly   652 LLQDPLLSPTTRAKLQGSAVDAAAVPLSDSQKRSYSPTKGPQGYSSGAPGSYKPISDPTADFLES 716
            .|..|...|:|.:....|....|....:.:         ||...::...|...|::.|::
  Fly   738 TLSIPEQKPSTGSSSSSSTSSTATTTTNGN---------GPYSNATFVSGFSAPLTPPSS----- 788

  Fly   717 QRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAAAAAAAGAAGAAAAAAKPKKRR 781
                 .|..:..:.:.....|........|.|||.|.......:.|.|...|.||.
  Fly   789 -----LPANLNNTGSGCNTTLTSVTTISTPSSPTATVSTTASESVAPALSNASAAE--------- 839

  Fly   782 VKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTL------------- 833
               ::|...|..:....:| :|||...|. ..||        |...|..|||
  Fly   840 ---ILINEIFINNIINNNA-SGSITAETA-AKPA--------GSSTPSAGTLLFSTLSEQERLES 891

  Fly   834 --------EALNTKTGKKEVFQGDVDGKT-GNLHLVSGVADPKTGRLDDTL------GQIVCITP 883
                    ::||......||.....:.|| .|....|.:..|.:....|.:      .::|....
  Fly   892 QKTNQQMNQSLNLNQNHSEVDAPPSEKKTPSNYPDSSRIPFPSSSNSKDMVSPWLVSSEVVSAPK 956

  Fly   884 -QDNPVVELTVITSRI 898
             :::.::..:|||:::
  Fly   957 GRESAIIRKSVITTQL 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	80/191 (42%)
		FERM_N	36..98	CDD:286467	23/61 (38%)
		FERM_M	116..224	CDD:278785	47/107 (44%)
		FERM_C_4_1_family	219..312	CDD:270005	37/94 (39%)
		FA	323..363	CDD:285894	14/39 (36%)
		PQQ_2	829..>972	CDD:290097	17/99 (17%)
		4_1_CTD	1612..1698	CDD:283537
yrt	NP_650291.1	B41	60..250	CDD:214604	80/191 (42%)
		FERM_N	62..124	CDD:286467	23/61 (38%)
		FERM_M	143..250	CDD:278785	47/107 (44%)
		FERM_C_NBL4_NBL5	246..339	CDD:270007	35/92 (38%)
		FA	352..392	CDD:285894	14/41 (34%)
		PHA03255	771..>924	CDD:165513	35/184 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455764
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840