DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and dnr1

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_001261137.1	Gene:	dnr1 / 37575	FlyBaseID:	FBgn0260866	Length:	696	Species:	Drosophila melanogaster

Alignment Length:	856	Identity:	158/856 - (18%)
Similarity:	263/856 - (30%)	Gaps:	302/856 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VTLLDGSLLDVSIDRKAIGRDVINSICAGLNLI-EKDYFGLTYETP----TDPRTWLDLEKPVSK 95
            |.|.:|:...|..|.||.|::.:..:|..:|:| |.:||||.:.||    :..|.|::|...:|
  Fly     5 VNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRLS- 68

  Fly    96 FFRTDTWP--------LTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPC-TFVTHALLG 151
               .|:..        |...|||:.|....|:|.: |....:|.|.|:|||||.. .:...|.|.
  Fly    69 ---GDSGSSGSGIQLMLALRVKFWVPVHFILQESV-RNLFYMQARRDLLEGRLTAPDWSGAAKLA 129

  Fly   152 SYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHK---THKGQSPAEAELHYLENA 213
            :.|.|::                  .:..|:::...|..|.:.:   ..:.|...:|:.|.||..
  Fly   130 ALLCQAD------------------GLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQ 176

  Fly   214 KKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGE 278
            :|
  Fly   177 RK--------------------------------------------------------------- 178

  Fly   279 FEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYKGRTQAESTN 343
              :.|..:.||  ..|.:|:  || :||.....|                         .|.||.
  Fly   179 --EKEHVLSFK--KRRLSKQ--KS-MEHIEVCTL-------------------------PAASTT 211

  Fly   344 TPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADGDAHSRSPIKNKKE 408
            :...:..|..:.:.|.:...|.|....|.::....:..||..:.......| :..:.:|::..:|
  Fly   212 SCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQTGLD-ERLASNPLRVYEE 275

  Fly   409 -----------------KDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALAAGA 456
                             :.|.:..||.:.:...|..|....:..::||             ..|.
  Fly   276 YFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLE-------------GYGE 327

  Fly   457 AAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRK--------SKSGSPSKDGK----DKSGKDK 509
            ...:.|..|:   .:.:.|.:.|..|:.:...|.|        :.:.|..:..|    |.....|
  Fly   328 ELFSGVTTNE---SATRCDIAVGAHGITVCRGGEKQSIPFGAIAAAKSLRRTFKLEYVDDHNDRK 389

  Fly   510 DKEVGRLGLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTP 574
            :.|:......:.:||..:..:::   |.....|.||..|...||      |..|..:......|.
  Fly   390 ELEIKLPKQPIAAGLYRSITERH---AFYVCDKVRGVVTNQFTR------DLKGTIASMFMENTE 445

  Fly   575 GGFRYDQD---------PNSRKS-----------GAD--------------GQEQLSP------- 598
            .|.||..|         ..:|::           ||:              |:..:||
  Fly   446 LGKRYVFDIQHTCREVHDQARRTLHERGGDLVAEGAEGCSAVAGGLGASAVGEPGVSPWAMALTT 510

  Fly   599 ---TSQQKKIGLAFNYAPGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLLQDPLLS- 659
               .|...||.||.......|.|::...:.                 ::|...:.|:..|..::
  Fly   511 GAGGSMAGKIDLAIREKEAREAAIERCVDT-----------------RISEAMQCKICMDRAINT 558

  Fly   660 ---------------------PTTRAKLQGSAVDAAAVP-LSDSQKRSYSPTKGPQGYSSGAPGS 702
                                 |..|.|:. |.|.....| |..||..|.:.|..    ||...|.
  Fly   559 VFNPCCHVIACAQCAARCSNCPNCRVKIT-SVVKIYLPPELRTSQTGSGATTTS----SSSIMGD 618

  Fly   703 YKPISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAAAAAAAGA 767
            .:         :|.|...::...:..:.|.:.||             ...|.|..|.|..|.||
  Fly   619 GQ---------VEEQLLQQQLDEISAAPASLEAG-------------ADAGVGVGGMAVGAGAG- 660

  Fly   768 AGAAAAAAKPK 778
            |||.....:||
  Fly   661 AGATGPGGQPK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	52/204 (25%)
		FERM_N	36..98	CDD:286467	22/66 (33%)
		FERM_M	116..224	CDD:278785	24/111 (22%)
		FERM_C_4_1_family	219..312	CDD:270005	9/92 (10%)
		FA	323..363	CDD:285894	5/39 (13%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
dnr1	NP_001261137.1	B41	3..>143	CDD:214604	44/160 (28%)
		FERM_N	5..67	CDD:286467	21/61 (34%)
		FERM_M	93..>143	CDD:278785	16/68 (24%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	23/121 (19%)
		zf-C3HC4_3	544..589	CDD:290631	5/45 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455765
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940