DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and epb41b

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_778259.1	Gene:	epb41b / 326287	ZFINID:	ZDB-GENE-030130-1	Length:	1534	Species:	Danio rerio

Alignment Length:	1307	Identity:	326/1307 - (24%)
Similarity:	529/1307 - (40%)	Gaps:	364/1307 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLT-YETPTDPRTWLDLEKPVSKFFR 98
            ||..||.:|....::|.::|:|:.|.:|..|||:|:|||||. :::||: |.|||..|.:.|..:
Zfish     5 RVNFLDDTLFTWELERDSLGQDLFNKVCEHLNLLERDYFGLVMWDSPTN-RVWLDCAKEIRKQIK 68

  Fly    99 TDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEMGDYD 163
            :......|::|||||:||.|.||||||.|||.:|.|||.|||||.....||||||.|||.:||||
Zfish    69 SPVAEFFFSIKFYPPDPSILAEDITRYFLCLHLRKDILIGRLPCPSDILALLGSYTVQSTLGDYD 133

  Fly   164 AEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGVDLHPAKD 228
             ..:....|::...:||||:.|||:|||:||.|::..|||:|:|.:|||...|.|||||||||||
Zfish   134 -PNLHKNNYVRKIVLAPNQSKELEEKVMELHATYRFMSPAQADLLFLENVMGLPMYGVDLHPAKD 197

  Fly   229 SEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTIGFKLANH 293
            :.|.|:|||||:.||:||.|.::.|.|.||::||||:||:.|.:|:||.|.:..|..:.|.|||:
Zfish   198 ASGEDVMLGVCSEGLIVYEDGVKTNSFFWPRVLKISHKRNTFLLKMRPSEEDASEGNLSFSLANY 262

  Fly   294 RAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYKGRTQAE--STNTPVDRTPPKFNRT 356
            ||.|:|||..||||:|||....:  :|:|.....||.:||.||.|:|  ..::.:.|.||:|.|.
Zfish   263 RACKQLWKCSVEHHSFFRNRLQD--TKAKRLLTLGSRFRYHGRKQSECVEASSNITRAPPRFTRY 325

  Fly   357 LSGARLTSRSMDALALAEKEKV-----------------------ARKSSTLDHRGDR---NADG 395
            ....:.....:|.|.|..:.:|                       ::|.....|..|.   ..||
Zfish   326 SIKRKANEEILDVLKLPVRAEVDDWFLVYGPEKWHIYTSDDVMLESQKLQEYKHHADDWCVLLDG 390

  Fly   396 DAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKE-------REKRELEEKKKAEKAAKAALA 453
            ...|.|.::...:.:..:| .|...|:|..:|.|.|:       .|:.::.||:..:.....
Zfish   391 SPFSLSGVQQLLQTEEQRE-DLETSKEKLTDEFEIKQSYQVQVVHERSDVLEKELPDYEIMR--- 451

  Fly   454 AGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRK------SKSGSPSKDGKDKSGKDKDKE 512
                     |.|:||.:            ||    |.:      :|..:.::|..:|..:..::.
Zfish   452 ---------NLNEELLE------------VG----GERIQRVVMTKEWTQTQDNGEKRVERVERR 491

  Fly   513 VGRLGLVVTS----GLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYT 573
            |     :||:    |.||..:...:
Zfish   492 V-----IVTNEKMVGSGDTSESLEI---------------------------------------- 511

  Fly   574 PGGFRYDQDPNSRKSGADGQEQLSPTSQQKKIGLAFNYAPGNENALKETAEKLKAGQLSPRTQDK 638
                   .:....|..|.|::.:.  .::.::||.                  :...|..|.|..
Zfish   512 -------MEQRLEKVEAIGRKLVE--VEELRVGLQ------------------EVESLEQRLQQA 549

  Fly   639 LNRG-QLSPKSRAKLLQD--PLLSPTTRAKLQGSAVDAAAVPLSDSQKRSYSPTKGPQGYSSGAP 700
            ...| ||..|....:..|  ||....|..:..|...|       :.|:..|.|
Zfish   550 EKEGLQLMKKDDWYIFLDCRPLTIIETLRERPGVVRD-------ELQQIVYVP------------ 595

  Fly   701 GSYKPISDPTADFLESQRYNKEPGY-----VGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAA 760
               |||             .||..:     |.|...:::..|:..:.|...|
Zfish   596 ---KPI-------------KKEDDWFILFDVHPQTTEISQLLSDVSSSIPEG------------- 631

  Fly   761 AAAAAGAAGAAAAAAKPKKRRVKIMVITSKFDPST--------KRIDAENGSIEH---------- 807
                        |.|:..||.|:.:.:.....|.|        .|:..|....||
Zfish   632 ------------AQAEEVKREVEKIELVLPEKPKTLMREETIQSRVTTEEIQKEHQEQVTVNHGR 684

  Fly   808 -STGIL-----DPATGLIDTKYGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNLHLVSGVADP 866
             .|.||     :|.:...|..:.|:|             |..:.....|...:...|
Zfish   685 SQTAILEQRATEPQSNQEDDWFVVLD-------------GSPKTSASTVKSTSVEFH-------- 728

  Fly   867 KTGRLDDTLGQIVCITPQDNPVVELTVITSRIDPAT-GKIDTVNGDVERSLGVLNLDTGLLDTKY 930
                 ::|..:::..|.|.   :::||...|..|.| .|..|..||||....:: .|....:|..
Zfish   729 -----EETREEVIQRTEQK---LQVTVQDRRPQPITVEKRTTQAGDVEDDWFII-FDVSPKETVR 784

  Fly   931 GE-----INTRTGELKAIDPKSGKIV----VSKNVKVD-PGTGQITILGI----VDPKTNKIDPN 981
            |.     :.:|..|:::...|..:::    ||...::. |.|.:|::..|    |:|:  .||.:
Zfish   785 GPAVEVFVESREQEIQSRVRKEERVIEVMTVSTREQITVPETKRISVTQIPQFPVEPR--DIDDD 847

  Fly   982 ------------------QGRLIEV-----GQQI-------DPIVEVTSLAGKFDSKRNIIDPKT 1016
                              :|..:||     .|:|       :.::|||:::    ::..|..|:|
Zfish   848 WFQLFDKVLYEEESFPSVRGSAVEVFVESREQEIQSRVRKEERVIEVTTVS----TREQITVPET 908

  Fly  1017 AQVE-TSGGQFDPKAGKIDTKYGQI-DLVKHTITFNDPKSGKTVTRDIKIEPTTGQIVLKNQVNP 1079
            .::. |...||..::..||..:.|: |.|.:.........|..|  ::.:|..      :.::..
Zfish   909 KRISVTQIPQFPVESRDIDDDWFQLFDKVLYEEESFPSVQGPAV--EVFVESR------EQEIQS 965

  Fly  1080 KNNKPDKDYARIISLRIV---QQRVDPATKAPITEVSASKDKDIVVDPKS-NQIWVPTGATDPAT 1140
            :..|.:    |:|.:..|   :|...|.||    .:|.::.....|:|:. :..|..  ..|...
Zfish   966 RVRKEE----RVIEVMTVGTREQITVPETK----RISVTQIPQFPVEPRDIDDDWFQ--LFDKVP 1020

  Fly  1141 KEQQYISSSVDPKTGYVITIYGYLDPKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGEP 1205
            .|::...|...|..        :::.:..:|:.:.:.:...||:...|.:        :|.|...
Zfish  1021 YEEESFPSVQGPAV--------FVESREQQIESRVRKEERVIKVMTVSTR--------EQITVTK 1069

  Fly  1206 LYAATQV 1212
            ..:.||:
Zfish  1070 RISVTQI 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	95/189 (50%)
		FERM_N	36..98	CDD:286467	26/62 (42%)
		FERM_M	116..224	CDD:278785	61/107 (57%)
		FERM_C_4_1_family	219..312	CDD:270005	54/92 (59%)
		FA	323..363	CDD:285894	13/41 (32%)
		PQQ_2	829..>972	CDD:290097	29/157 (18%)
		4_1_CTD	1612..1698	CDD:283537
epb41b	NP_778259.1	B41	4..193	CDD:214604	95/189 (50%)
		FERM_N	6..69	CDD:286467	26/63 (41%)
		FERM_M	88..193	CDD:278785	60/105 (57%)
		FERM_C_4_1_family	188..281	CDD:270005	54/92 (59%)
		FA	290..331	CDD:285894	13/40 (33%)
		SAB	1451..1497	CDD:282265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586178
Domainoid	1	1.000	57	1.000	Domainoid score	I10815
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800