DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and Epb41l2

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_017445330.1	Gene:	Epb41l2 / 309557	RGDID:	1563977	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	998	Identity:	320/998 - (32%)
Similarity:	467/998 - (46%)	Gaps:	213/998 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVS 94
            |..||:||||||:.....::::|.|:.:.:.:|..|||:|||||||.::...:.:.|||..|.:.
  Rat   211 KTVLAKVTLLDGTEFSCDLEKRAKGQALFDRVCEHLNLLEKDYFGLIFQEHPEQKNWLDPAKEIK 275

  Fly    95 KFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEM 159
            :..|:..|..||.||||||:||||.||||||.||||:|.||..|||||:||||||||||.:|:|.
  Rat   276 RQLRSLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDISSGRLPCSFVTHALLGSYTLQAEH 340

  Fly   160 GDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGVDLH 224
            ||||.||..: ..|.||:.||....|||:||.:|||||:|.|||:|:..:|||||:|:|||||||
  Rat   341 GDYDPEEYDS-IDLGDFQFAPTHNKELEEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLH 404

  Fly   225 PAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTIGFK 289
            .|||||||||.|||||:|||:|:|:||||||||||||||||||.:||||:||||.||:|||||||
  Rat   405 HAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYIKVRPGELEQFESTIGFK 469

  Fly   290 LANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYKGRTQAES--TNTPVDRTPPK 352
            |.||||||:|||.|||||||:||::||...|:| |...||.:||.|||||::  .:|.:||..|:
  Rat   470 LPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTK-FLTLGSKFRYSGRTQAQTREASTLIDRPAPQ 533

  Fly   353 FNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADGDAHSRSPIKNKKEKDADKEAKL 417
            |.|  :.::..|||:|...:.    |..:|...|..|. ..:|.......:.....:|..::.|.
  Rat   534 FER--ASSKRVSRSLDGAPIG----VVDQSLMKDFPGP-PGEGSVPGPGVVSYTTVQDGRRDGKS 591

  Fly   418 REKKQKEKEEKERKEREKRELEEKKKAEKAAKAALAAGAAAGAAVNG--------NDELNDSNKS 474
            ..|                           ....||.|......|:|        |..|.|.:|:
  Rat   592 PTK---------------------------VTPLLAEGKKNTLRVDGDNIYVRHSNLMLEDLDKA 629

  Fly   475 DKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQNLD-EAAR 538
            .::..:....:....|.....:|..       :..:.|..|:..:....|..|.|....| .:|:
  Rat   630 QEAILKHQASVSELKRNFMESTPEP-------RPSEWEKRRVTPLSCQILARNSQTLFKDILSAK 687

  Fly   539 NAAKNRGSTTP-GVTRQYEYAVDNDGNTSPTRKSYTPGGFRYD---QDPNSRKSGADG------- 592
            ..::...:.|| ..|:..|..:        |...::..||.:.   ..|::....|:|
  Rat   688 LMSQMAAARTPEEATQSLEEEI--------TSILFSGQGFSHSVKASFPSATTWTAEGTVVNANA 744

  Fly   593 -QEQLS--PTSQQKKIGLAF-NYAP--GNENALKETAEKLKAGQLSPRTQ---------DKLNRG 642
             :|.||  |.|:..:...|. :..|  |..:|:|.:.|.|...:...|.:         :::|..
  Rat   745 PREPLSSAPFSRLPETPRALVSEGPCTGTRDAVKSSHETLNVVEEKKRAEVGKGESVITEEMNGK 809

  Fly   643 QLSPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVPLSDSQKRSY-SPTKGPQGYSSGAPGSYKP- 705
            :|||.|          .|....|::         |::.....|. |.:......|....|.|:|
  Rat   810 ELSPGS----------GPGETRKVE---------PMAHKDSTSLSSESSSSSSESEEDVGEYQPH 855

  Fly   706 --ISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPGAAAAAAAGAA 768
              :::.|  ..|.|.|.:|.                   .::||...|.   ....||...|...
  Rat   856 HRVTEGT--IREEQEYEEEL-------------------EEEPGQGAKV---VEREAAMPEAIPD 896

  Fly   769 GAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTL 833
            ..|.|:..|.:...:..|:..|       :..|.|:                        .:||.
  Rat   897 RQAGASVLPVETEAQENVVAQK-------LPGEKGA------------------------HRGTA 930

  Fly   834 EALNTKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGRLDDTLGQIVCITPQDNPVVELTVIT--- 895
            |...::..:::  |..|:|:..:|.:             |.|.:|||  |.:.|||:..::|
  Rat   931 EQDMSEEAEED--QHRVNGEVPHLDI-------------DGLPEIVC--PSEPPVVKTEMVTISD 978

  Fly   896 --SRIDPATGKIDTV--------------NGDVERSLGVLNLDTGLLDTKYGEINTRTGELKAID 944
              .|.:.:|.::..|              :|......||| |....:.::.....|.|...|.:
  Rat   979 ASQRTEISTKEVPIVQTETKTITYESPQIDGGAGGDSGVL-LTAQTITSESASTTTTTHITKTV- 1041

  Fly   945 PKSG--------KIVVSKNVKVD 959
             |.|        :||::.:..:|
  Rat  1042 -KGGISETRIEKRIVITGDAALD 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	105/189 (56%)
		FERM_N	36..98	CDD:286467	23/61 (38%)
		FERM_M	116..224	CDD:278785	70/107 (65%)
		FERM_C_4_1_family	219..312	CDD:270005	77/92 (84%)
		FA	323..363	CDD:285894	16/41 (39%)
		PQQ_2	829..>972	CDD:290097	33/158 (21%)
		4_1_CTD	1612..1698	CDD:283537
Epb41l2	XP_017445330.1	PTZ00121	<4..>216	CDD:173412	2/4 (50%)
		B41	215..404	CDD:214604	105/189 (56%)
		FERM_C_4_1_family	399..492	CDD:270005	77/92 (84%)
		FA	502..545	CDD:400882	18/45 (40%)
		SAB	622..662	CDD:398195	6/46 (13%)
		4_1_CTD	989..1094	CDD:399118	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345156
Domainoid	1	1.000	168	1.000	Domainoid score	I3725
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1131
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm45774
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890