DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and Epb41

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_006538970.1	Gene:	Epb41 / 269587	MGIID:	95401	Length:	1025	Species:	Mus musculus

Alignment Length:	932	Identity:	316/932 - (33%)
Similarity:	455/932 - (48%)	Gaps:	157/932 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EIK--PSAPAEPETPTKSKP-KSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGL 65
            |:|  |.:.||.|.....|| :...:.|     .:|:|||.::.:..:::.|.|:|::..:|..|
Mouse   185 EVKEDPESRAEREPEASQKPVRRHRNMH-----CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHL 244

  Fly    66 NLIEKDYFGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQ 130
            ||:|:|||||........:||||..|.:.|..|...|..||.||||||:|:||.||||||:||||
Mouse   245 NLLEEDYFGLALWDSATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQ 309

  Fly   131 VRNDILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHK 195
            :|.||:.|||||:|.|.||||||.:|||:|||| .|:....|:.|||:|||||.|||:|||:|||
Mouse   310 LRQDIVAGRLPCSFATLALLGSYTIQSELGDYD-PELHGMDYVSDFKLAPNQTKELEEKVMELHK 373

  Fly   196 THKGQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKI 260
            :::..:||:|:|.:|||||||:|||||||.|||.|||||:||||:||||||:||||||||.|||:
Mouse   374 SYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKV 438

  Fly   261 LKISYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFP 325
            |||||||..|:|||||||.|.|||||||||.::||||||||.||||||||||.:.:.:.||| |.
Mouse   439 LKISYKRSSFFIKIRPGEQEHYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK-FL 502

  Fly   326 VFGSTYRYKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEK-EKVARKSSTLDH 387
            ..||.:||.|||||::  .:..:||..|.|.||.|  :..|||:|..|.||. ::..|.:|....
Mouse   503 ALGSKFRYSGRTQAQTRQASALIDRPAPHFERTAS--KRASRSLDGAAAAESTDRSPRPTSAPAI 565

  Fly   388 RGDRNADGDAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAAL 452
            ...:..:|..   :||| |..|:|   .|:.||:.:|..|....|..:....||...|.....:
Mouse   566 AQSQVTEGPG---APIK-KTPKEA---VKVEEKRGEEPAEPAEPEPTEAWKVEKTHTEVTVPTS- 622

  Fly   453 AAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKD--KSGKDKDKEVGR 515
                      ||       :::.|.:|:                    |:|  :..|.|.:.:..
Mouse   623 ----------NG-------DQTQKLAGK--------------------GEDLIRMRKKKRERLDG 650

  Fly   516 LGLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYD 580
            ..:.:..   .|...::||::.....|:..|.:. :.:.:..:|.....:...::..|...|| .
Mouse   651 ENIYIRH---SNLMLEDLDKSQEEIKKHHASISE-LKKNFMESVPEPRPSEWDKRLSTHSPFR-T 710

  Fly   581 QDPNSRKSGADGQEQLSPTSQQKKIGLAFNYAPGNENALK--ETAEKLKAGQLSPRTQDKLNRGQ 643
            .:.|.:....||.::.|.....:|:|     .|.:.|.::  |.|...|.....|.::.:..:..
Mouse   711 LNINGQVPTGDGVKKTSILPSGRKVG-----GPESVNGIRTEEVATVTKGPSTYPASEWECPKQS 770

  Fly   644 LSPKSRAKLLQDPLLSPTT-------------RAKLQGSA--VDAAAVPLSDSQKRSYSPTKGPQ 693
            :.|..  .|:..|..||.:             ..|.||:|  :||..:|            .||.
Mouse   771 VVPSQ--SLMTTPPASPQSFGSGSLSINSKEAEEKEQGAAGYLDAEEMP------------TGPS 821

  Fly   694 GYSSGAPGSYKPISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKKPGSPTKTGKGAPG 758
            |...|........|.|                |.|:...:..|...|..|::.|:..:|.:...|
Mouse   822 GECLGVEEQASAFSFP----------------VTPASCQLQLGGEKADSSEELGAAAETLETQSG 870

  Fly   759 AAAAAAAG--------------------AAGAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENG 803
            :...:..|                    .....|.|.|.:.....:.::.::    ||.|..|..
Mouse   871 SFLDSPVGNQFPTLIRSFQPPLVKTQTVTISDTANAVKSEIPTKDVPIVHTE----TKTITYEAA 931

  Fly   804 SIEHSTGILDPA-----------TGLIDTKYGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNL 857
            ..|.|.|.|||.           |....|...:....||.:.  .|:..|:.|..||.|.....:
Mouse   932 QTEDSNGDLDPGVLLTAQTITSETTSSTTTTQITKTVKGGIS--ETRIEKRIVITGDADIDHDQV 994

  Fly   858 HLVSGVADPKTGRLDDTLGQIV 879
             ||..:.:.|....|.::.::|
Mouse   995 -LVQAIKEAKEQHPDMSVTKVV 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	104/189 (55%)
		FERM_N	36..98	CDD:286467	23/61 (38%)
		FERM_M	116..224	CDD:278785	70/107 (65%)
		FERM_C_4_1_family	219..312	CDD:270005	76/92 (83%)
		FA	323..363	CDD:285894	17/41 (41%)
		PQQ_2	829..>972	CDD:290097	13/51 (25%)
		4_1_CTD	1612..1698	CDD:283537
Epb41	XP_006538970.1	B41	212..402	CDD:214604	105/195 (54%)
		FERM_C_4_1_family	397..490	CDD:270005	76/92 (83%)
		FA	500..542	CDD:370090	18/44 (41%)
		SAB	662..709	CDD:367916	6/47 (13%)
		4_1_CTD	915..1021	CDD:368659	25/108 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841756
Domainoid	1	1.000	165	1.000	Domainoid score	I3894
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1278
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm43697
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.890