DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cora and Frmd6

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_006240213.1	Gene:	Frmd6 / 257646	RGDID:	727810	Length:	622	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	84/469 - (17%)
Similarity:	171/469 - (36%)	Gaps:	103/469 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTD--------------PRTWLDLEKPVS 94
            :.:.|:.|.:...::..:|..|.|.:...|||:.....:              |:.|   :|..|
  Rat    28 VSIIINVKILCHQLLVQVCDLLRLKDSHLFGLSVIQNNEHVYMELSQKLYKYCPKEW---KKEAS 89

  Fly    95 KFFRTD-TWPLT---------FAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHAL 149
            |..:.: ||.:.         |.|::|......:.:.|.||:....:|..:|..:.......:.|
  Rat    90 KVRQYEVTWGIDQFGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQCVLREEAYFL 154

  Fly   150 LGSYLVQSEMGDY-----DAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHY 209
            |.::.:|:::|::     ..:.....||...:.::......:...:.::|:.....:.:||.|.|
  Rat   155 LAAFALQADLGNFKRKVHHGDYFEPEAYFPAWVVSKRGKDYILKHIPNMHRDQFALTASEAYLKY 219

  Fly   210 LENAKKL---AMYGVDLHPAKDSEGVD--IMLGVCASGLLVYR----DKLRINRFAWPKILKISY 265
            ::.|.:|   |::...|:  ||...|:  :.||:...|:.:::    :|..:..|.|..:.|:.:
  Rat   220 IKEAVRLDDVAIHYYRLY--KDKREVEGSLTLGLTMRGIQIFQNLEEEKQLLYDFPWTNVGKLVF 282

  Fly   266 KRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPV----------SK 320
            ....|  :|.|.........:.:.....|:...|......|..:..|   :||          .:
  Rat   283 VGKKF--EILPDGLPSARKLVYYTGCPTRSRHLLQLLSNSHRLYMNL---QPVLRHLRKQEENEE 342

  Fly   321 SKMFPVFGSTYRYKGRTQAESTNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTL 385
            .|.:           |....|.|..:|..|.:.....||:  ::.||       |.|...:.||.
  Rat   343 KKQY-----------RESYISDNLDLDMDPLEKRSRASGS--SAGSM-------KHKRLSRHSTA 387

  Fly   386 DHRGDRNA--DGDAHSRSP---------IKNKKEK--------------DADKEAKLREKKQKEK 425
            .|.....:  :.|...|.|         :.::|.|              ..:...|.|.::..:.
  Rat   388 SHSSSHTSGIETDTKPRDPGPEDGYSGSVMHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDSQD 452

  Fly   426 EEKERKEREKRELE 439
            :|.|....:.|:||
  Rat   453 DEIEMLVDDPRDLE 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	37/211 (18%)
		FERM_N	36..98	CDD:286467	13/67 (19%)
		FERM_M	116..224	CDD:278785	19/115 (17%)
		FERM_C_4_1_family	219..312	CDD:270005	17/98 (17%)
		FA	323..363	CDD:285894	7/39 (18%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
Frmd6	XP_006240213.1	B41	20..234	CDD:214604	37/208 (18%)
		FERM_N	20..82	CDD:286467	8/53 (15%)
		FERM_M	123..234	CDD:278785	19/110 (17%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	21/114 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840