Protein Alignment cora and FRMD3

DIOPT Version :9

• Sequence 1: NP_523791.2
• Gene: cora / 37205
• FlyBaseID: FBgn0010434
• Length: 1698
• Species: Drosophila melanogaster
• Sequence 2: NP_777598.3
• Gene: FRMD3 / 257019
• HGNCID: 24125
• Length: 597
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 154/494 - (31%)
• Similarity: 245/494 - (49%)
• Gaps: 81/494 - (16%)

  Fly    23 SSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWL 87
            ||..|..:.....:.|||.|.:...|.|:..|:.:|:.||...:|:||||||:.|..|...|.||
Human    23 SSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWL 87

  Fly    88 DLEKPVSKFFRT-DTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLG 151
            :..|.:.|..:| ..:.:.|.|||||.||.::||::|||.|.||::.||..|||.|:|...|.||
Human    88 EPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLG 152

  Fly   152 SYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTH-KGQSPAEAELHYLENAKK 215
            :.:||:|:||||.:|.|.. |:.:|:|.|.|:.:||.|::::||.. :||||..||.:.|..|..
Human   153 ACIVQAELGDYDPDEHPEN-YISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHT 216

  Fly   216 LAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFE 280
            |..||||.||.|||.|....||..|:|.:|::...||:...||.:.|:.::...||:   .|..:
Human   217 LETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYV---IGTQK 278

  Fly   281 QYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTP---EPVSKSKMFPVFGSTYRYKGRTQAE-- 340
            :.::.:.|..:...|.|.|||..||:..|::....   :.||.||:| ..||.:||.|:...|
Human   279 EKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIF-FKGSRFRYSGKVAKEVV 342

  Fly   341 STNTPVDRTPPKFNRTLSGARLT-SRSMDAL----------------ALAEKEKVARKSSTLDHR 388
            ..::.:.|.||:.:|    |.:| |||..:|                :.:|:|:.......:...
Human   343 EASSKIQREPPEVHR----ANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPLGEGVPLP 403

  Fly   389 GDRNADGDAHSRSPIKNKKEKD---ADKEAKLRE------------------------------- 419
            .:.|......|.||:|..:|.:   :::|.|::|
Human   404 KEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDMLFD 468

  Fly   420 ---KKQKEKEEKERKE-----------REKRELEEKKKA 444
               :.:.|:|:.:..|           .|:.||:|.::|
Human   469 CPSRLELEREDTDSFEDLEADENAFLIAEEEELKEARRA 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	83/191 (43%)
		FERM_N	36..98	CDD:286467	24/61 (39%)
		FERM_M	116..224	CDD:278785	50/108 (46%)
		FERM_C_4_1_family	219..312	CDD:270005	32/92 (35%)
		FA	323..363	CDD:285894	12/41 (29%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
FRMD3	NP_777598.3	B41	33..225	CDD:214604	83/192 (43%)
		FERM_N	36..98	CDD:286467	24/61 (39%)
		FERM_M	117..225	CDD:278785	50/108 (46%)
		PH-like	206..309	CDD:302622	37/105 (35%)
		FA	323..>357	CDD:285894	11/34 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..403		2/19 (11%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740