DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cora and Frmd3

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_766457.1	Gene:	Frmd3 / 242506	MGIID:	2442466	Length:	595	Species:	Mus musculus

Alignment Length:	356	Identity:	132/356 - (37%)
Similarity:	197/356 - (55%)	Gaps:	17/356 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWL 87
            ||..|..:.....:.|||.|.:...|.|:..|:.:|..||...:|:||||||:.|..|...|.||
Mouse    23 SSIKSLNQEMKCTIRLLDDSEVSCHIQRETKGQFLIEYICNYYSLLEKDYFGIRYVDPEKQRHWL 87

  Fly    88 DLEKPVSKFFRT-DTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLG 151
            :..|.:.|..:: ..:.:.|.|||||.||.::||::|||.|.||::.||..|||.|:|...|.||
Mouse    88 EPNKSIFKQMKSHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLG 152

  Fly   152 SYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTH-KGQSPAEAELHYLENAKK 215
            :.:||:|.|||..:|.|.. |:.:|:|.|.|:.:||.|:|::|... :|||||.||.:.|..|..
Mouse   153 ACIVQAEFGDYYPDEHPEN-YISEFEIFPKQSQKLERKIMEIHNNELRGQSPAIAEFNLLLKAHT 216

  Fly   216 LAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFE 280
            |..||||.||.|||.|....||..|:|.:|::...||:...|..:.|:.::...||:   .|..:
Mouse   217 LETYGVDPHPCKDSRGATAFLGFTAAGFVVFQGNKRIHLRKWSDVCKLKFEGKTFYV---IGSQK 278

  Fly   281 QYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTP---EPVSKSKMFPVFGSTYRYKGRTQAE-- 340
            :..:.:.|..:...|.|.|||..||:..|::....   :.||.||:| ..||.:||.|:...|
Mouse   279 EKNAVLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIF-FKGSRFRYSGKVAKEVV 342

  Fly   341 STNTPVDRTPPKFNRTLSGARLT-SRSMDAL 370
            ..::.:.|.||:.:|    ..:| |||..:|
Mouse   343 EASSKIQRDPPEVHR----VNITQSRSFHSL 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	82/191 (43%)
		FERM_N	36..98	CDD:286467	24/61 (39%)
		FERM_M	116..224	CDD:278785	50/108 (46%)
		FERM_C_4_1_family	219..312	CDD:270005	31/92 (34%)
		FA	323..363	CDD:285894	11/41 (27%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
Frmd3	NP_766457.1	B41	33..225	CDD:214604	82/192 (43%)
		FERM_N	36..99	CDD:286467	24/62 (39%)
		FERM_M	117..225	CDD:278785	50/108 (46%)
		PH-like	206..309	CDD:302622	36/105 (34%)
		FA	323..>357	CDD:285894	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841780
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740