DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and EPB41L2

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_024302117.1	Gene:	EPB41L2 / 2037	HGNCID:	3379	Length:	1079	Species:	Homo sapiens

Alignment Length:	815	Identity:	297/815 - (36%)
Similarity:	407/815 - (49%)	Gaps:	180/815 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EPETPTKSKPKSSS--SSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFG 74
            |.:|......|:|.  :...|....:||||||:.....:::.|.|:.:.:.:|..|||:||||||
Human   196 EVQTNELKAEKASQKVTKKTKTVQCKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFG 260

  Fly    75 LTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGR 139
            |.::...:.:.|||..|.:.:..|...|..||.||||||:||||.||||||.||||:|.||..||
Human   261 LLFQESPEQKNWLDPAKEIKRQLRNLPWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGR 325

  Fly   140 LPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAE 204
            |||:||||||||||.:|:|:||||.||..: ..|.:|:.||.||.|||:||.:|||||:|.|||:
Human   326 LPCSFVTHALLGSYTLQAELGDYDPEEHGS-IDLSEFQFAPTQTKELEEKVAELHKTHRGLSPAQ 389

  Fly   205 AELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHH 269
            |:..:|||||:|:|||||||.|||||||||.|||||:|||:|:|:||||||||||||||||||.:
Human   390 ADSQFLENAKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSN 454

  Fly   270 FYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRYK 334
            ||||:||.|.||:||||||||.||||||:|||.|||||||:||::||...|:| |...||.:||.
Human   455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAK-FLTLGSKFRYS 518

  Fly   335 GRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARK-----SSTLDHRGD-- 390
            |||||::  .:|.:||..|.|.||.|  :..|||:|...:...::...|     :..:...|.
Human   519 GRTQAQTRQASTLIDRPAPHFERTSS--KRVSRSLDGAPIGVMDQSLMKDFPGAAGEISAYGPGL 581

  Fly   391 ------RNADGDAHSRSP--------IKNKKE------------------KDADK--------EA 415
                  ::.||....|||        |:.||.                  ::.||        :|
Human   582 VSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQA 646

  Fly   416 KLREKKQKEKE---EKERKEREKR-----------ELEEK-----------KKAEKAAKAALAAG 455
            .:.|.|:...|   |....|.|||           .|||:           ..:.||...:....
Human   647 SISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSLEEEITSILFSEKGFSDSMKATFTSATTW 711

  Fly   456 AAAGAAVNGN---DELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKD--KSGKD------- 508
            .|.||.|:.|   ::|:.|..|.          ....|..:|..|....:|  ||..:
Human   712 TAEGAVVSANAPSEKLSSSPFSH----------LLETRAPESEGPCTGARDAVKSSHETLNIVEE 766

  Fly   509 -KDKEVGRLGLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKS- 571
             |..|||:...|:|       ::.|..|.:..:.       ||..|:.|.....|..:..:..|
Human   767 KKRAEVGKDERVIT-------EEMNGKEISPGSG-------PGEIRKVEPVTQKDSTSLSSESSS 817

  Fly   572 ------------YTP------GGFRYDQ--------DPNSRKSGADGQE---QLSPTSQ------ 601
                        |.|      |..|.:|        :|.......:.:|   :.||.:|
Human   818 SSSESEEEDVGEYRPHHRVTEGTIREEQEYEEEVEEEPRPAAKVVEREEAVPEASPVTQAGASVI 882

  Fly   602 ------QKKIGLAFNYAPGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLLQ-----D 655
                  |:.:|.  ...|| |.::.|.|.|...|:.:.....|:| |::|......|.|     :
Human   883 TVETVIQENVGA--QKIPG-EKSVHEGALKQDMGEEAEEEPQKVN-GEVSHVDIDVLPQIICCSE 943

  Fly   656 PLLSPTTRAKLQGSAVDAAAVPLSDSQKRSYSPTK 690
            |   |..:.::         |.:||:.:|:...||
Human   944 P---PVVKTEM---------VTISDASQRTEISTK 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	105/189 (56%)
		FERM_N	36..98	CDD:286467	23/61 (38%)
		FERM_M	116..224	CDD:278785	71/107 (66%)
		FERM_C_4_1_family	219..312	CDD:270005	76/92 (83%)
		FA	323..363	CDD:285894	18/41 (44%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
EPB41L2	XP_024302117.1	Neuromodulin_N	<9..222	CDD:331332	5/25 (20%)
		B41	220..409	CDD:214604	105/189 (56%)
		FERM_C_4_1_family	404..497	CDD:270005	76/92 (83%)
		FA	507..549	CDD:312314	19/44 (43%)
		SAB	630..673	CDD:309500	11/42 (26%)
		4_1_CTD	967..1072	CDD:310467	297/815 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151659
Domainoid	1	1.000	168	1.000	Domainoid score	I3823
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1279
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm41652
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.750