DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and EPB41

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_011539258.1	Gene:	EPB41 / 2035	HGNCID:	3377	Length:	1031	Species:	Homo sapiens

Alignment Length:	924	Identity:	311/924 - (33%)
Similarity:	461/924 - (49%)	Gaps:	136/924 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EIKPSAPAEPETPTKSKP-KSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNL 67
            |..|.:.||.|.....|| :...:.|     .:|:|||.::.:..:::.|.|:|::..:|..|||
Human   186 EESPQSKAETELKASQKPIRKHRNMH-----CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNL 245

  Fly    68 IEKDYFGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVR 132
            :|:|||||........:||||..|.:.|..|...|..||.||||||:|:||.||||||:||||:|
Human   246 LEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLR 310

  Fly   133 NDILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTH 197
            .||:.|||||:|.|.||||||.:|||:|||| .|:....|:.|||:|||||.|||:|||:|||::
Human   311 QDIVAGRLPCSFATLALLGSYTIQSELGDYD-PELHGVDYVSDFKLAPNQTKELEEKVMELHKSY 374

  Fly   198 KGQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILK 262
            :..:||:|:|.:|||||||:|||||||.|||.|||||:||||:||||||:||||||||.|||:||
Human   375 RSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLK 439

  Fly   263 ISYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVF 327
            |||||..|:|||||||.|||||||||||.::||||||||.||||||||||.:.:.:.||| |...
Human   440 ISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSK-FLAL 503

  Fly   328 GSTYRYKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMD-ALALAEKEKVARKSSTLDHRG 389
            ||.:||.|||||::  .:..:||..|.|.||.|  :..|||:| |.|:...::..|.:|......
Human   504 GSKFRYSGRTQAQTRQASALIDRPAPHFERTAS--KRASRSLDGAAAVDSADRSPRPTSAPAITQ 566

  Fly   390 DRNADG---DAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAA 451
            .:.|:|   ||.::..:..|.:|:.     ::.:.:||.|..|:.|.|..|      |.|..|..
Human   567 GQVAEGGVLDASAKKTVVPKAQKET-----VKAEVKKEDEPPEQAEPEPTE------AWKVEKTH 620

  Fly   452 LAAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRL 516
            :.......   ||:.....:.|::...           |..|......||::
Human   621 IEVTVPTS---NGDQTQKLAEKTEDLI-----------RMRKKKRERLDGEN------------- 658

  Fly   517 GLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQ 581
             :.:..   .|...::||::.....|:..|.:. :.:.:..:|.....:...::..|...|| ..
Human   659 -IYIRH---SNLMLEDLDKSQEEIKKHHASISE-LKKNFMESVPEPRPSEWDKRLSTHSPFR-TL 717

  Fly   582 DPNSRKSGADGQEQLSPTSQQKKIGLAFNYAPGNENALK--ETAEKLKAGQLSPRTQDKLNRGQL 644
            :.|.:....:|.::.|....::|:|     .|.:.|.::  |.|...|....:|.::.:..:..:
Human   718 NINGQIPTGEGVKKTSVLPSERKVG-----GPESINGIRTEEVAVVTKGPSTNPDSEWEGPKHSV 777

  Fly   645 SPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVPLSDSQKRSYSPTKGPQGY------SSGAPGSY 703
            .| |::::       .|:...||..|..:    ||.|.|.:....:|..||      ..|..|..
Human   778 VP-SKSQM-------TTSSESLQSFAFGS----LSISSKETEEKEEGAAGYLDIKEMPRGPTGGC 830

  Fly   704 KPISDPTADFLESQRYNKEPGYVGPSKADVAAGLAGAAGSKK---PGSPTKTGKGA--------- 756
            ..:.:..:....|         |.|:...:..|:..|..|::   ||.|.....|:
Human   831 IGVEEQASALKFS---------VTPASCQLQPGVKKAESSEEHVTPGEPPGKQNGSFLDFHVGNQ 886

  Fly   757 ----------PGAAAAAAAGAAGAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGI 811
                      |.........:..|.|..::...:.|.|:      ...||.|..|....:.::|.
Human   887 FPTLIRSFQPPLVKTQTVTISDNANAVKSEIPTKDVPIV------HTETKTITYEAAQTDDNSGD 945

  Fly   812 LDPATGLIDTKYGVID--PKKGTLEAL---------NTKTGKKEVFQGDVDGKTGNLHLVSGVAD 865
            |||  |::.|...:..  |...|...:         .|:..|:.|..||.|.....: ||..:.:
Human   946 LDP--GVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQV-LVQAIKE 1007

  Fly   866 PKTGRLDDTLGQIV 879
            .|....|.::.::|
Human  1008 AKEQHPDMSVTKVV 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	104/189 (55%)
		FERM_N	36..98	CDD:286467	23/61 (38%)
		FERM_M	116..224	CDD:278785	70/107 (65%)
		FERM_C_4_1_family	219..312	CDD:270005	77/92 (84%)
		FA	323..363	CDD:285894	17/41 (41%)
		PQQ_2	829..>972	CDD:290097	12/60 (20%)
		4_1_CTD	1612..1698	CDD:283537
EPB41	XP_011539258.1	B41	211..401	CDD:214604	105/195 (54%)
		FERM_N	214..274	CDD:286467	22/59 (37%)
		FERM_M	296..401	CDD:278785	69/105 (66%)
		FERM_C_4_1_family	396..489	CDD:270005	77/92 (84%)
		FA	499..541	CDD:285894	18/44 (41%)
		SAB	667..713	CDD:282265	6/46 (13%)
		4_1_CTD	921..1027	CDD:283537	25/110 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151638
Domainoid	1	1.000	165	1.000	Domainoid score	I3915
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1279
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm41652
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750