DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cora and frm-1

DIOPT Version :9

Sequence 1:NP_523791.2 Gene:cora / 37205 FlyBaseID:FBgn0010434 Length:1698 Species:Drosophila melanogaster
Sequence 2:NP_493601.2 Gene:frm-1 / 173360 WormBaseID:WBGene00001488 Length:4648 Species:Caenorhabditis elegans


Alignment Length:2039 Identity:433/2039 - (21%)
Similarity:704/2039 - (34%) Gaps:626/2039 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 PAEPETPTKS-KPKSSSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYF 73
            |.:.:.||.| :|:.|     |..||:|.|.||...:..:::.:.|..:...:...|::.|::||
 Worm     7 PGDQKHPTTSQQPRDS-----KMQLAKVLLPDGVQKEFEVNKNSEGEALFRQVTRDLSIEEREYF 66

  Fly    74 GLT-YETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILE 137
            .|. |:.....|.||..:|.::|..:...|..:|.|||||..|:.:.:|..||::.||:|.|:|.
 Worm    67 SLCFYDKDEGTRHWLYNDKNIAKQIKGLPWEFSFEVKFYPTTPTTIVDDHARYYVFLQLRRDLLT 131

  Fly   138 GRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDF----KIAPNQTA--ELEDKVMDLHKT 196
            ||||.|..||:||||::.|.|.||..||  .|.|| :.|    |:.|:..|  |...|::|||:.
 Worm   132 GRLPATADTHSLLGSFVAQIEFGDAPAE--MTDAY-EQFIVASKLVPSAQANPETYKKIVDLHRE 193

  Fly   197 HKGQSPAEAELHYLENAKKLAMYGVDLHPA---KDSEGVDIMLGVCASGLLVYRDKLRINRFAWP 258
            .:||:|:|||..:|::.|.||:||:.|..|   ||.:.||:  |:.|:|:.:|:|:.:.:.|:|.
 Worm   194 MRGQTPSEAENQFLDHCKHLALYGIHLFKAISDKDKKPVDV--GIGAAGINIYQDEQKTHSFSWQ 256

  Fly   259 KILKISYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKM 323
            .|:||.|:|.:|.||::.|..|:.|.|:.|||.||.|||:.||..|||||||||:.||..:....
 Worm   257 NIIKIGYRRTYFSIKLKAGTVEKNEKTLYFKLPNHVAAKRTWKCAVEHHTFFRLIQPEDKTHKSF 321

  Fly   324 FPVFGSTYRYKGRTQAESTNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHR 388
            |......:||:||||.::                   ::.|:..|            |.||:|  
 Worm   322 FNFGSQRFRYQGRTQFQT-------------------KIASQMFD------------KPSTVD-- 353

  Fly   389 GDRNADGDAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERK-EREKRELEEKKK--------- 443
                       |:|....:.....:..||:.....:.|.::|: ||.:|.|..|..         
 Worm   354 -----------RAPSAMSQPIATAENQKLQTLNLTDSELEQRQFERYRRALTPKSYTSSRQDDDA 407

  Fly   444 ------AEKAAKAALAAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKS---------- 492
                  |:.:..:.|...:.:|.......||:.|.:.|.||.......:.|.|.|          
 Worm   408 VSTATFAKYSRPSTLLVVSTSGHHQQSPHELSYSPRGDDSSNYSSAAYYMSERSSLRTPSSAYYP 472

  Fly   493 --------------------------KSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQ 531
                                      ::.|.|..|...||..::             |.....|.
 Worm   473 PSEYTSPTSPVYFEGQHHGEYHVQMRQTASTSATGPSNSGARRN-------------LFGRASDA 524

  Fly   532 NLDEAARNAAKNRGSTTP-----GVTRQYEYA------------VDNDGN---TSPTRK------ 570
            ...:|:|::.:......|     .:...|.|:            |.::|:   .||.|:      
 Worm   525 RSSQASRDSVRLVSFHEPVDPNEPIPNTYPYSELPQIPIERIVHVYHEGHYDRLSPRRQQRPELP 589

  Fly   571 ----SYTPGGFRYDQDPNSRKSGADGQEQLSPTSQQKKIGLAF------------NYA-----PG 614
                :|||            ::|....:.|.|..:..:..:.|            |.|     ||
 Worm   590 YGFGNYTP------------RNGVSHVDNLQPDGEMDQQPIRFYVDVRHSGASRRNLAKRLSHPG 642

  Fly   615 NENALKETAEKLKAGQLSPR--------TQDKLNRGQLSPKSRAKLLQDPLLSPTTRAKLQGSAV 671
            .|: :||        |:.|:        ..|.::|.:||     :.:|...:...||....|.::
 Worm   643 KED-IKE--------QIDPKDYYFSASLASDPIHRTELS-----REVQPANIQQYTRRYHHGDSI 693

  Fly   672 DAAAVP----LSDSQKRSYSPTKGPQGYSSGAPGSYKPISDPTADFLESQRYNKEPGYVGPSKAD 732
            .....|    ::.....:.:...|..|.||         |:..|..  |||.......|.....|
 Worm   694 HKPDTPQYRLITHVHPLAVTNRDGRDGQSS---------SNLNATI--SQREQVVSTKVRRESPD 747

  Fly   733 VAAGLAGAAGSKKPGSPTKT----GKGAPGAAAAAAAGAAGAAAAAAKPKKRRVKIMVITSKFDP 793
            ....:..:|...:.|:.|.|    .:....||...............|.||...||...::|.|.
 Worm   748 ADRRVRLSASVDRSGNLTDTTEEMTRSTNEAATPTTVVTTRIVEKKGKGKKNNQKIPPSSNKTDH 812

  Fly   794 S---------------TKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTLEALN------ 837
            :               ||:..........||   ...||.:|..:...|.:..|....|      
 Worm   813 ASFEGQEKRSRFGGFFTKKTSQTLSGYPEST---SQFTGELDATHRDDDLEPSTFSHSNKSQQYS 874

  Fly   838 TKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGRLDDTLGQIVCITPQDNPVVELTVITSRIDPAT 902
            :|..|..:...:....:||...:..|..|:..:....:.:|  ....|..|||            
 Worm   875 SKQDKTIITSVESKSDSGNKKRLMAVESPEVPKKYRLIARI--RHEGDEDVVE------------ 925

  Fly   903 GKIDTVNGDVERSLGVLNLDTGLLDTKYGEINTRTGELKAIDPKSGKIV--------VSKNVKVD 959
                    ..|:...|.:..:|:|:..|     |..||..|...|...|        :.:...:.
 Worm   926 --------KPEKYSFVTDSHSGMLEETY-----RQKELDQIPISSHAAVYHHGKSWSIQRQSTLS 977

  Fly   960 PGTGQITILGIVDPKTNKIDPNQGRLI-EVGQQIDPIV------EVTSLAGKFDSKRNIIDPKTA 1017
            ....:|:.||..|...:|  ..:.||| .:..:.:.:.      |.:|:.|.|:....:      
 Worm   978 QDRSKISSLGADDANLSK--KKEVRLIARIESKTEEVAHKKHKKEGSSVFGFFNRPTKL------ 1034

  Fly  1018 QVETSGGQFDPKA----GKIDTKYGQIDLVKH--------------------------------- 1045
               .:|.::..|:    |.:||.....||.:|                                 
 Worm  1035 ---PAGTEYPEKSNVFTGDLDTTGRTSDLEQHPFQHGTHPAYSPKNVEAYQPSENSNGESKTDIP 1096

  Fly  1046 ------TITFNDPKSGKTVTRDI------------------KIEPTTGQIVL-----KNQVNPKN 1081
                  :.:::.|....::.||:                  :||.....:..     |...:||.
 Worm  1097 AAYGFPSTSYDGPLETTSLERDLQHVTIAAHSNVYHHGDSSRIEKHASPVATPEKKQKKVKSPKK 1161

  Fly  1082 NK------PDKDYARIISLRIVQQRVDPATKAPITEVSASKDKDIVVDPKSNQIWVPTGATDPAT 1140
            .|      |:|...|:|:      ||....:|.|.:|...|:                      |
 Worm  1162 EKVDVPAEPEKKEIRLIA------RVRTEPEAEIVDVPVVKE----------------------T 1198

  Fly  1141 KEQQYISSSVDPKTGYVITIYGYLDPKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQAT--- 1202
            ||::..|.|..|..|:.        .||.:..|.|..        |.:.:.|  |||:|...   
 Worm  1199 KEKKGDSKSKLPTFGFF--------SKTTKTTKTTGY--------PETSEAY--TGELDTTDRTH 1245

  Fly  1203 ---------GE-PLYA---------ATQVDPESGEVYTKLAR--------VDPKTGKIVIVRILL 1240
                     || |.|:         .|..:||. :.|..:||        |..|.....|...|.
 Worm  1246 DFEGTSFEHGEHPAYSPKQTVIEAIETPAEPEK-KRYRLIARFRHEGDEDVVEKPDPYQIATTLY 1309

  Fly  1241 ISKTDERGRPEEIDPSTCEIDPV-----------SGRVLKFFNKTVYVYNMIDPVTG---EIVQV 1291
            ....||..|..::|.:     |:           |.|:.|..:....:......|..   |.|.|
 Worm  1310 DGPLDEISRETDLDHA-----PIADHANVYHHGDSSRIEKHASPVATLEKKQKKVKSPKKEKVDV 1369

  Fly  1292 DPNDPRFAGARTTVTHTMTLTGEI--DPVTGRIKSEYGDID---PNTGDIDPATAVTDPVTGKLI 1351
             |.:|.....|...........||  .||....|.:.||..   |..|.....|..| ..||   
 Worm  1370 -PAEPEKKEIRLIARVRTEPEAEIVDVPVVKETKEKKGDSKSKLPTFGFFSKTTKTT-KTTG--- 1429

  Fly  1352 LNYAQIDPSHFGKQAQVQTTTETVPITRQQFFDG-----------VKHISKGA----------LR 1395
              |.:...::.|   ::.||..|..:....|..|           ::.|...|          .|
 Worm  1430 --YPETSEAYTG---ELDTTDRTHDLEGTSFEHGEHPAYSPKQTVIEAIETPAEPEKKRYRLIAR 1489

  Fly  1396 RDSEGSSDDDMTAQYGADQVNEILIGSPAGQAG-------------------------GKLGKPV 1435
            ...||  |:|:..:....|:...|...|..:..                         .|...||
 Worm  1490 FRHEG--DEDVVEKPDPYQIATTLYDGPLDEISRETDLDHTPIADHANVYHHGDSSRIEKHASPV 1552

  Fly  1436 STPTVVKTTTKQVLTKNIDGVTHNVEEEVRNLGTGE-----------VTYSTQEHKADATPTDLS 1489
            :||...:...|....:.:|......::|:|.:....           |...|:|.|.|:.....:
 Worm  1553 ATPEKKQKKVKSPKKEKVDVPAEPEKKEIRLIARVRTEPEAEIVDVPVVKETKEKKGDSKSKLPT 1617

  Fly  1490 GAYVTATAVTTRTATTHEDLGKNAKTEQLEEKTVATTRTHD------------------------ 1530
            ..:.:.|..||:|....|.  ..|.||:|:    .|.|.||                        
 Worm  1618 FGFFSKTTKTTKTTGYPET--SEAYTEELD----TTDRIHDLEGTSFEHGEHSAYSPKQTVIETI 1676

  Fly  1531 -----PNKQQQRVVT-------QEVKTTATVTSGDQYQRRDSVSSTSSGDSGTPIDGPYDGASVV 1583
                 |.|::.|::.       ::|     |...|.||    :::|.       .|||.|..| .
 Worm  1677 ETPAEPEKKRYRLIARFRHEGDEDV-----VEKPDPYQ----IATTL-------YDGPLDEIS-R 1724

  Fly  1584 RTDNQKSPLFTTSATTGPHVESTRVVLGEDTPGFSGHGEIIST-----QTVSSKTRTVETITYKT 1643
            .||...:|: ...|....|.:|:|:         ..|...::|     :.|.|..:....:..:.
 Worm  1725 ETDLDHAPI-ADHANVYHHGDSSRI---------EKHASPVATLEKKQKKVKSPKKEKVDVPAEP 1779

  Fly  1644 ERDGIVETRVEQKITIQSDGDPID 1667
            |:.   |.|:..::..:.:.:.:|
 Worm  1780 EKK---EIRLIARVRTEPEAEIVD 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
coraNP_523791.2 B41 34..224 CDD:214604 74/196 (38%)
FERM_N 36..98 CDD:286467 16/62 (26%)
FERM_M 116..224 CDD:278785 49/113 (43%)
FERM_C_4_1_family 219..312 CDD:270005 44/95 (46%)
FA 323..363 CDD:285894 7/39 (18%)
PQQ_2 829..>972 CDD:290097 27/156 (17%)
4_1_CTD 1612..1698 CDD:283537 8/61 (13%)
frm-1NP_493601.2 B41 27..221 CDD:214604 74/196 (38%)
PH-like 216..310 CDD:388408 44/95 (46%)
FA 321..357 CDD:370090 14/79 (18%)
4_1_CTD 4542..4646 CDD:368659
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 105 1.000 Domainoid score I4174
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101605
Panther 1 1.100 - - LDO PTHR23280
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4459
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.940

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