DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and Epb41l4a

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_038540.2	Gene:	Epb41l4a / 13824	MGIID:	103007	Length:	686	Species:	Mus musculus

Alignment Length:	710	Identity:	196/710 - (27%)
Similarity:	323/710 - (45%)	Gaps:	135/710 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VTLLDGSLLDVSIDRKAI-----GRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSK 95
            |.|||.|.|.::..::.|     |..|::.:...:||:|.|||||.|...:....|||..|.:::
Mouse    15 VLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFRHINLVEIDYFGLRYCDRSHQTYWLDPAKTLAE 79

  Fly    96 FFR-TDTWP---LTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQ 156
            ... .:|.|   |.|.:|||..:|.:|||:||||...|||:.|.|:|||||.....|.:|:|.:|
Mouse    80 HKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDALQGRLPCPVNIAAQMGAYAIQ 144

  Fly   157 SEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGV 221
            :|:||:|..: .|..|:.:::..|:|..|||:.:..:|||..||:|:||||:||..||.|.||||
Mouse   145 AELGDHDPYK-HTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQAPSEAELNYLRTAKSLEMYGV 208

  Fly   222 DLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTI 286
            ||||.......:..||:..||::||::|.::.::.||:|.|:.:|...|.:::...:..  |::.
Mouse   209 DLHPVYGENKSEYFLGLTPSGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCN--ETSF 271

  Fly   287 GFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGS---TYRYKGRT----------- 337
            .|:..:..|.|.|||..||||||||:...|..|.|:....|||   .:||.|||
Mouse   272 FFEARSKTACKHLWKCSVEHHTFFRMPDTESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLSIQ 336

  Fly   338 ---------QAESTNTP--VDRTPP----KFNR----TLSGARLTSRSMDALALAEKEKVARKSS 383
                     ::.|...|  |.:|.|    ..||    |.:|....:..:.|.:..:..|.|:..:
Mouse   337 LPRPNQNVVRSRSKTYPKRVAQTQPTGSNNINRITANTENGENEGTTKIIAPSPVKSFKKAKNEN 401

  Fly   384 TLD---------------HRGDRNADGDAHSRSP---------------------IKNKKEKDAD 412
            :.|               ..|..|:..| .::||                     ::.:|..::.
Mouse   402 SPDPQRSKSHAPWEENGPQSGLYNSSSD-RTKSPKFPCARQRNLSCGSDNDSSQLMRRRKAHNSG 465

  Fly   413 KEAKLREKKQKEK-------EEKERKEREKRELEEKKKAEKAAKAALAAGAAAGAAVNGNDELND 470
            :::.|:::::...       .|.|...||.|   :|:...:.....:.:|....|.:....|.|.
Mouse   466 EDSDLKQRRRSRSRCNTSSGSESENSNREHR---KKRNRTRQENDMVDSGPQWEAVLRRQKEKNQ 527

  Fly   471 SNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQ---N 532
            ::.:::.|..|          |:|.||....|::..|...||     ||..|||.:.|..:   .
Mouse   528 ADPNNRRSRHR----------SRSRSPDIQAKEELWKHIQKE-----LVDPSGLSEEQLKEIPYT 577

  Fly   533 LDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTS-----PTRKSYTPGGFRYDQDPNSRKSGADG 592
            ..|...:..:.|.|.:|...|||..:..:||..|     .::....|      ..|.:|.|.|.|
Mouse   578 KVETQGDPVRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVP------PLPVTRSSDAQG 636

  Fly   593 QEQLSPTSQQKKIGLAFNYAPGNENALKETAEKLK----AGQLSPRTQDKLNRGQLSPKS 648
            ..  ..|..|::        .|::::|.|...:|.    ||:.:.:|...:...:|..::
Mouse   637 SG--GSTVHQRR--------NGSKDSLIEEKSQLSTINPAGKPTAKTIKTIQAARLKAET 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	82/196 (42%)
		FERM_N	36..98	CDD:286467	22/66 (33%)
		FERM_M	116..224	CDD:278785	52/107 (49%)
		FERM_C_4_1_family	219..312	CDD:270005	34/92 (37%)
		FA	323..363	CDD:285894	17/72 (24%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
Epb41l4a	NP_038540.2	B41	13..211	CDD:214604	82/196 (42%)
		FERM_N	15..80	CDD:286467	22/64 (34%)
		FERM_M	105..211	CDD:278785	52/106 (49%)
		FERM_C_NBL4_NBL5	207..296	CDD:270007	32/90 (36%)
		FA	311..354	CDD:285894	9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..669		70/371 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810