DRSC/TRiP Functional Genomics Resources

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Protein Alignment cora and Epb41l4a

DIOPT Version :10

Sequence 1:NP_523791.2 Gene:cora / 37205 FlyBaseID:FBgn0010434 Length:1698 Species:Drosophila melanogaster
Sequence 2:NP_038540.2 Gene:Epb41l4a / 13824 MGIID:103007 Length:686 Species:Mus musculus


Alignment Length:710 Identity:196/710 - (27%)
Similarity:323/710 - (45%) Gaps:135/710 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 VTLLDGSLLDVSIDRKAI-----GRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSK 95
            |.|||.|.|.::..::.|     |..|::.:...:||:|.|||||.|...:....|||..|.:::
Mouse    15 VLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFRHINLVEIDYFGLRYCDRSHQTYWLDPAKTLAE 79

  Fly    96 FFR-TDTWP---LTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQ 156
            ... .:|.|   |.|.:|||..:|.:|||:||||...|||:.|.|:|||||.....|.:|:|.:|
Mouse    80 HKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDALQGRLPCPVNIAAQMGAYAIQ 144

  Fly   157 SEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGV 221
            :|:||:|..: .|..|:.:::..|:|..|||:.:..:|||..||:|:||||:||..||.|.||||
Mouse   145 AELGDHDPYK-HTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQAPSEAELNYLRTAKSLEMYGV 208

  Fly   222 DLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTI 286
            ||||.......:..||:..||::||::|.::.::.||:|.|:.:|...|.:::...:..  |::.
Mouse   209 DLHPVYGENKSEYFLGLTPSGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCN--ETSF 271

  Fly   287 GFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGS---TYRYKGRT----------- 337
            .|:..:..|.|.|||..||||||||:...|..|.|:....|||   .:||.|||           
Mouse   272 FFEARSKTACKHLWKCSVEHHTFFRMPDTESNSLSRKLSKFGSISYKHRYSGRTALQMSRDLSIQ 336

  Fly   338 ---------QAESTNTP--VDRTPP----KFNR----TLSGARLTSRSMDALALAEKEKVARKSS 383
                     ::.|...|  |.:|.|    ..||    |.:|....:..:.|.:..:..|.|:..:
Mouse   337 LPRPNQNVVRSRSKTYPKRVAQTQPTGSNNINRITANTENGENEGTTKIIAPSPVKSFKKAKNEN 401

  Fly   384 TLD---------------HRGDRNADGDAHSRSP---------------------IKNKKEKDAD 412
            :.|               ..|..|:..| .::||                     ::.:|..::.
Mouse   402 SPDPQRSKSHAPWEENGPQSGLYNSSSD-RTKSPKFPCARQRNLSCGSDNDSSQLMRRRKAHNSG 465

  Fly   413 KEAKLREKKQKEK-------EEKERKEREKRELEEKKKAEKAAKAALAAGAAAGAAVNGNDELND 470
            :::.|:::::...       .|.|...||.|   :|:...:.....:.:|....|.:....|.|.
Mouse   466 EDSDLKQRRRSRSRCNTSSGSESENSNREHR---KKRNRTRQENDMVDSGPQWEAVLRRQKEKNQ 527

  Fly   471 SNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQ---N 532
            ::.:::.|..|          |:|.||....|::..|...||     ||..|||.:.|..:   .
Mouse   528 ADPNNRRSRHR----------SRSRSPDIQAKEELWKHIQKE-----LVDPSGLSEEQLKEIPYT 577

  Fly   533 LDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTS-----PTRKSYTPGGFRYDQDPNSRKSGADG 592
            ..|...:..:.|.|.:|...|||..:..:||..|     .::....|      ..|.:|.|.|.|
Mouse   578 KVETQGDPVRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVP------PLPVTRSSDAQG 636

  Fly   593 QEQLSPTSQQKKIGLAFNYAPGNENALKETAEKLK----AGQLSPRTQDKLNRGQLSPKS 648
            ..  ..|..|::        .|::::|.|...:|.    ||:.:.:|...:...:|..::
Mouse   637 SG--GSTVHQRR--------NGSKDSLIEEKSQLSTINPAGKPTAKTIKTIQAARLKAET 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
coraNP_523791.2 B41 34..224 CDD:214604 82/196 (42%)
FERM_C_4_1_family 219..312 CDD:270005 34/92 (37%)
FA 324..364 CDD:462582 17/72 (24%)
4_1_CTD 1613..1698 CDD:461774
Epb41l4aNP_038540.2 B41 13..211 CDD:214604 82/196 (42%)
FERM_C_NBL4_NBL5 207..296 CDD:270007 32/90 (36%)
FA 311..355 CDD:462582 10/43 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..669 70/371 (19%)
Blue background indicates that the domain is not in the aligned region.

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