Protein Alignment cora and FRMD6

DIOPT Version :10

• Sequence 1: NP_523791.2
• Gene: cora / 37205
• FlyBaseID: FBgn0010434
• Length: 1698
• Species: Drosophila melanogaster
• Sequence 2: NP_001253975.1
• Gene: FRMD6 / 122786
• HGNCID: 19839
• Length: 622
• Species: Homo sapiens
• Alignment Length: 649
• Identity: 105/649 - (16%)
• Similarity: 219/649 - (33%)
• Gaps: 206/649 - (31%)

  Fly    44 LDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTD--------------PRTWLDLEKPVS 94
            |::.|:.|.:...::..:|..|.|.:...|||:.....:              |:.|   :|..|
Human    28 LNIIINVKILCHQLLVQVCDLLRLKDCHLFGLSVIQNNEHVYMELSQKLYKYCPKEW---KKEAS 89

  Fly    95 KFFRTD-TWPLT---------FAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHAL 149
            |..:.: ||.:.         |.|::|......:.:...||:....:|..:|..:.......:.|
Human    90 KVRQYEVTWGIDQFGPPMIIHFRVQYYVENGRLISDRAARYYYYWHLRKQVLHSQCVLREEAYFL 154

  Fly   150 LGSYLVQSEMGDYDAEE-----MPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHY 209
            |.::.:|:::|::...:     ....||...:.::......:...:.::||.....:.:||.|.|
Human   155 LAAFALQADLGNFKRNKHYGKYFEPEAYFPSWVVSKRGKDYILKHIPNMHKDQFALTASEAHLKY 219

  Fly   210 LENAKKL---AMYGVDLHPAKDSEGVDIMLGVCASGLLVYR----DKLRINRFAWPKILKISYKR 267
            ::.|.:|   |::...|:..|......:.||:...|:.:::    :|..:..|.|..:.|:.:..
Human   220 IKEAVRLDDVAVHYYRLYKDKREIEASLTLGLTMRGIQIFQNLDEEKQLLYDFPWTNVGKLVFVG 284

  Fly   268 HHFYIKIRPGEFEQYESTIGFKLANHRAAKKL--WKSCVEHHTFFRLMTPEPVSKSKMFPVFGST 330
            ..|  :|.|....              :|:||  :..|             |:....:..:..::
Human   285 KKF--EILPDGLP--------------SARKLIYYTGC-------------PMRSRHLLQLLSNS 320

  Fly   331 YRYKGRTQAESTNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADG 395
            :|.....|      ||.|
Human   321 HRLYMNLQ------PVLR----------------------------------------------- 332

  Fly   396 DAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALAAGAAA-G 459
              |.|. ::..:||...:|:.:.:....:.::.|::.|.........|.::.::.:.|:.::: .
Human   333 --HIRK-LEENEEKKQYRESYISDNLDLDMDQLEKRSRASGSSAGSMKHKRLSRHSTASHSSSHT 394

  Fly   460 AAVNGNDELNDSNKSDKSSGRRGVGIFSSG--RKSKS-------GSPSKDGKDKSGKDK------ 509
            :.:..:.:..|:...|..|        ||.  ||.|:       ||....|.:..|||:
Human   395 SGIEADTKPRDTGPEDSYS--------SSAIHRKLKTCSSMTSHGSSHTSGVESGGKDRLEEDLQ 451

  Fly   510 DKEVGRL-------------GLVVT--------------------SGLGDNQQDQNLDEAARNAA 541
            |.|:..|             .|.|:                    |||...:...:...::....
Human   452 DDEIEMLVDDPRDLEQMNEESLEVSPDMCIYITEDMLMSRKLNGHSGLIVKEIGSSTSSSSETVV 516

  Fly   542 KNRGSTTPGV-----------TRQYEYAVDN-----------DGNTSPTRKSYTPG-GFRYDQD 582
            |.||.:|..:           |.::..::|:           .|....|.:|||.| |...|::
Human   517 KLRGQSTDSLPQTICRKPKTSTDRHSLSLDDIRLYQKDFLRIAGLCQDTAQSYTFGCGHELDEE 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	38/211 (18%)
		FERM_C_4_1_family	219..312	CDD:270005	16/98 (16%)
		FA	324..364	CDD:462582	5/39 (13%)
		4_1_CTD	1613..1698	CDD:461774
FRMD6	NP_001253975.1	FERM_F1_FRMD6	15..120	CDD:340718	19/94 (20%)
		FERM_M	118..234	CDD:459788	19/115 (17%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	24/191 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..445		16/88 (18%)