Protein Alignment cora and Epb41l3

DIOPT Version :10

• Sequence 1: NP_523791.2
• Gene: cora / 37205
• FlyBaseID: FBgn0010434
• Length: 1698
• Species: Drosophila melanogaster
• Sequence 2: XP_038938855.2
• Gene: Epb41l3 / 116724
• RGDID: 71089
• Length: 1205
• Species: Rattus norvegicus
• Alignment Length: 1726
• Identity: 438/1726 - (25%)
• Similarity: 642/1726 - (37%)
• Gaps: 682/1726 - (39%)

  Fly    18 KSKPKSSSSSHGKPAL----------ARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDY 72
            |...|||||...:..|          .:|||||||.....:|:::.|:.:.:.:|..|||:||||
  Rat   109 KLSQKSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDY 173

  Fly    73 FGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILE 137
            |||||....:.:.|||..|.:.|..|:..|..:|.||||||:|:||.||||||:||||:|:||:.
  Rat   174 FGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVS 238

  Fly   138 GRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSP 202
            |||||:|||.||||||.||||:||||.:|. ...|:.:|:.|||.|.||||||::|||:|:|.:|
  Rat   239 GRLPCSFVTLALLGSYTVQSELGDYDPDEC-GNDYISEFRFAPNHTKELEDKVIELHKSHRGMTP 302

  Fly   203 AEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKR 267
            ||||:|:|||||||:|||||||.|||||||:|||||||||||:|||:||||||||||:|||||||
  Rat   303 AEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKR 367

  Fly   268 HHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYR 332
            ::||||||||||||:||||||||.||||||:|||.||||||||||:.||  :..|.|...||.:|
  Rat   368 NNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPE--APPKKFLTLGSKFR 430

  Fly   333 YKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADG 395
            |.|||||::  .:..:||..|.|.|:.|.....|||:|..::.|..::..|        |..:..
  Rat   431 YSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMK--------DSMSAA 487

  Fly   396 DAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALA--AGAAA 458
            :..:......|.....:....:..:|:.|:|..|.::|       :||||:|...|..  .|.:.
  Rat   488 EVGTGQYATTKVISQTNLITTVTPEKKAEEEHVEEEDR-------RKKAEEATPVAALRHEGKSP 545

  Fly   459 GAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSG 523
            |   :|:|....|..|                 :....||.....:..|:|::
  Rat   546 G---HGSDSCPLSPPS-----------------AHLDPPSPTELRRRCKEKER------------ 578

  Fly   524 LGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQDPNSRKS 588
                              .:.||..|    :.|.:.::|..    .|:|..     |||
  Rat   579 ------------------ASPGSAVP----RAELSSESDAQ----GKAYLG-----DQD------ 606

  Fly   589 GADGQEQLSPTSQQKKIGLAFNY-APGNENA--------LKETAEKL--KAGQLS-PRTQDKLNR 641
                              :||:| .|..:..        |.|:...|  :.|.|| |    .|:.
  Rat   607 ------------------VAFSYRQPAGKGTTLFSFSLQLPESFPSLLDEDGYLSFP----NLSE 649

  Fly   642 GQLSPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVP---------LSDSQKRSYSPTKGPQGYSS 697
            ..|.|:|....|  |:.||             :.:|         ||.|....|:.|
  Rat   650 TNLLPQSWQHFL--PIRSP-------------SLLPCFLFIFFFLLSASFSVPYALT-------- 691

  Fly   698 GAPGSYKPISDPTA---DFLESQRYNKEPGYVGPSKADVAAGLAG--AAGSKKPGSPTKTGKGAP 757
                    :|.|.|   .|||            |..|.::|.|..  :..|::.....:|...|.
  Rat   692 --------LSFPLALCLCFLE------------PKAASLSASLDNDPSDSSEEETDSERTDTAAD 736

  Fly   758 GAAAAAAAGAAGAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTK 822
            |..:|..:.....|...|:               :...|||..||..::||..:|:
  Rat   737 GETSATESDQEEDAELKAQ---------------NSLIKRIKGENVYVKHSNLMLE--------- 777

  Fly   823 YGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGRLDDTLGQIVCITPQDNP 887
                                                           .||.|..::|
  Rat   778 -----------------------------------------------ELDKTQDELV-------- 787

  Fly   888 VVELTVITSRIDPATGKIDTVNGDVERSLGVLNLDTGLLDTKYGEINTRTGELKAIDPKSGKIVV 952
                                                        :..|...|||.
  Rat   788 --------------------------------------------KHQTNISELKR---------- 798

  Fly   953 SKNVKVDPGTGQITILGIVDPKTNKIDPNQGRLIEVGQQIDPIVEVTSLAGKFDSKRNIIDPKTA 1017
                                           ..:|...:       |:|..:::.:.:     |:
  Rat   799 -------------------------------TFLETSTE-------TALTNEWEKRLS-----TS 820

  Fly  1018 QVETSGGQFDPKAGKIDTKYGQIDLVKHTITFNDPKSGKTVTRDIKIEPTTGQIVLKNQVNPKNN 1082
            .|..:..|.|..                                 .|||..          |:..
  Rat   821 PVRLAARQEDAP---------------------------------MIEPLV----------PEET 842

  Fly  1083 KPDKDYARIISLRIV--QQRVDPATKAPITEVSASKDKDIVVDPKSNQIWVPTGATDPATKEQQY 1145
            |.:::    ||.::|  ||...|..:   ::.|.:|        |:.:   ...|...||..|..
  Rat   843 KEERE----ISEKVVFLQQGTSPFLE---SQPSVTK--------KTRE---GVSADSAATSHQII 889

  Fly  1146 ISSSVDPKTGYVITIYGYLDPKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGEPLYAAT 1210
            ...||                            |:|:              |..|::||.|...:
  Rat   890 FQKSV----------------------------PSTL--------------ETKQSSGEKLMDGS 912

  Fly  1211 QVDPESGEVYTKLARVDPKTGKIVIVRILLISKTDERGRPEEIDPSTCEIDPVSGRVLKFFNKTV 1275
            ::                            :|..:...:|.|.      |..||.....:..|
  Rat   913 EI----------------------------LSLLESARKPTEF------IGGVSSTTQSWVQK-- 941

  Fly  1276 YVYNMIDPVTGEIVQVDPNDPRFAGARTTVTHTMTLTGEIDPVTGRIKSEYGDIDPNTGDIDPAT 1340
                                        ..|.|.|:..|::|                      |
  Rat   942 ----------------------------LETKTETIETEVEP----------------------T 956

  Fly  1341 AVTDPVTGKLILNYAQIDPSHFGKQAQVQTTTETVPITRQQFFDGVKHISKGALRRDSEGSSDDD 1405
            ....|::.:.:|.                   |||.:..       :|:.......|:..::.||
  Rat   957 PHPQPLSTEKVLQ-------------------ETVLVEE-------RHVMNVHASGDASHTARDD 995

  Fly  1406 MTAQYGADQVNEILIGSPAGQAGGKLGKPVSTPTVVKTTTKQVLTKNIDGVTHNVEEEVRNLGTG 1470
            :.|...|          ||.                                       |:.|.|
  Rat   996 VDATESA----------PAD---------------------------------------RHSGNG 1011

  Fly  1471 EVTYSTQEHKADATPTDLSGAYVTATAVTTRTATTHEDLGKNAKTEQLEEKTVATTRTHDPNKQQ 1535
            :                 .|:.||..|...|    .|:..|:|                 |.::|
  Rat  1012 K-----------------EGSSVTEAAKEQR----GEEADKSA-----------------PEQEQ 1038

  Fly  1536 QRVVTQEVKTTATVTSGDQYQRRDSVSSTSSGDSGTPIDGPYDGASVVRTDNQKSPLFTTSATTG 1600
            ...|:||....:.:.|.:..:::....|::.......:.....|...:.|..::.|:..|...|.
  Rat  1039 PATVSQEEDQVSAIHSSEGLEQKSHFESSTVKVESISVGSVSPGGVKLETSTKEVPVVHTETKTI 1103

  Fly  1601 PHVESTRVVLGED-TPGFSGHGEIISTQTVSSKTRTVETITY--KTERDGIVETRVEQKITIQSD 1662
            .: ||::|..|.| .||.     ::|.||::|:|.:..|.|:  ||.:.||.|||:|::|.|..|
  Rat  1104 TY-ESSQVDPGADLEPGV-----LMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGD 1162

  Fly  1663 GDPIDHDKALAEAIQEATAMNPDMTVEKIEIQQQTQ 1698
            .| ||||:|||:||:||...:|||:|.|:.:.::|:
  Rat  1163 AD-IDHDQALAQAIKEAKEQHPDMSVTKVVVHKETE 1197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	110/189 (58%)
		FERM_C_4_1_family	219..312	CDD:270005	81/92 (88%)
		FA	324..364	CDD:462582	16/41 (39%)
		4_1_CTD	1613..1698	CDD:461774	38/87 (44%)
Epb41l3	XP_038938855.2	None