DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and Epb41l3

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_038938840.1	Gene:	Epb41l3 / 116724	RGDID:	71089	Length:	1444	Species:	Rattus norvegicus

Alignment Length:	1773	Identity:	478/1773 - (26%)
Similarity:	721/1773 - (40%)	Gaps:	537/1773 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KSKPKSSSSSHGKPAL----------ARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDY 72
            |...|||||...:..|          .:|||||||.....:|:::.|:.:.:.:|..|||:||||
  Rat   109 KLSQKSSSSKLSRSPLKIVKRPKSMQCKVTLLDGSEYGCDVDKRSRGQVLFDKVCEHLNLLEKDY 173

  Fly    73 FGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILE 137
            |||||....:.:.|||..|.:.|..|:..|..:|.||||||:|:||.||||||:||||:|:||:.
  Rat   174 FGLTYRDAENQKNWLDPAKEIKKQIRSGAWHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVS 238

  Fly   138 GRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSP 202
            |||||:|||.||||||.||||:||||.:|. ...|:.:|:.|||.|.||||||::|||:|:|.:|
  Rat   239 GRLPCSFVTLALLGSYTVQSELGDYDPDEC-GNDYISEFRFAPNHTKELEDKVIELHKSHRGMTP 302

  Fly   203 AEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKR 267
            ||||:|:|||||||:|||||||.|||||||:|||||||||||:|||:||||||||||:|||||||
  Rat   303 AEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKR 367

  Fly   268 HHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYR 332
            ::||||||||||||:||||||||.||||||:|||.||||||||||:.||  :..|.|...||.:|
  Rat   368 NNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPE--APPKKFLTLGSKFR 430

  Fly   333 YKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADG 395
            |.|||||::  .:..:||..|.|.|:.|.....|||:|..::.|..::..|        |..:..
  Rat   431 YSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSLDGASVNENHEIYMK--------DSMSAA 487

  Fly   396 DAHSRSPIKNKKEKDADKEAKLREKKQKEKEEKERKEREKRELEEKKKAEKAAKAALA--AGAAA 458
            :..:......|.....:....:..:|:.|:|..|.::|       :||||:|...|..  .|.:.
  Rat   488 EVGTGQYATTKVISQTNLITTVTPEKKAEEEHVEEEDR-------RKKAEEATPVAALRHEGKSP 545

  Fly   459 GAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSG 523
            |   :|:|....|..|                 :....||.....:..|:|::
  Rat   546 G---HGSDSCPLSPPS-----------------AHLDPPSPTELRRRCKEKER------------ 578

  Fly   524 LGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQDPNSRKS 588
                              .:.||..|    :.|.:.::|..    .|:|..     |||
  Rat   579 ------------------ASPGSAVP----RAELSSESDAQ----GKAYLG-----DQD------ 606

  Fly   589 GADGQEQLSPTSQQKKIGLAFNY-APGNENA--------LKETAEKL--KAGQLS-PRTQDKLNR 641
                              :||:| .|..:..        |.|:...|  :.|.|| |    .|:.
  Rat   607 ------------------VAFSYRQPAGKGTTLFSFSLQLPESFPSLLDEDGYLSFP----NLSE 649

  Fly   642 GQLSPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVP---------LSDSQKRSYSPTKGPQGYSS 697
            ..|.|:|....|  |:.||             :.:|         ||.|....|:.|
  Rat   650 TNLLPQSWQHFL--PIRSP-------------SLLPCFLFIFFFLLSASFSVPYALT-------- 691

  Fly   698 GAPGSYKPISDPTA---DFLESQRYNKEPGYVGPSKADVAAGLAG--AAGSKKPGSPTKTGKGAP 757
                    :|.|.|   .|||            |..|.::|.|..  :..|::.....:|...|.
  Rat   692 --------LSFPLALCLCFLE------------PKAASLSASLDNDPSDSSEEETDSERTDTAAD 736

  Fly   758 GAAAAAAAGAAGAAAAAAKPKKRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTK 822
            |..:|..:.....|...|:               :...|||..||..::||..:|:
  Rat   737 GETSATESDQEEDAELKAQ---------------NSLIKRIKGENVYVKHSNLMLE--------- 777

  Fly   823 YGVIDPKKGTLEALNTKTGKKEVFQGDVDGKTGNLHLVSGVADPKTGRLDDTLGQIVCITPQDNP 887
                                                           .||.|..::|
  Rat   778 -----------------------------------------------ELDKTQDELV-------- 787

  Fly   888 VVELTVITSRIDPATGKIDTVNGDVERSLGVLNLDTGL-------LDTKYGEINTRTGELKAIDP 945
                            |..|...:::|:....:.:|.|       |.|....:..|..:...|:|
  Rat   788 ----------------KHQTNISELKRTFLETSTETALTNEWEKRLSTSPVRLAARQEDAPMIEP 836

  Fly   946 KSGKIVVSKNVKVDPGTGQITILGIVDPKTNKIDPNQGRLIEVGQQIDPIVEVTSLAGKFDSKRN 1010
                                    :|..:|.:......:::.:.|...|.:|
  Rat   837 ------------------------LVPEETKEEREISEKVVFLQQGTSPFLE------------- 864

  Fly  1011 IIDPKTAQVETSGGQFDPKAGKIDTKYGQIDLVKHTITFNDPKSGKTVTRDIKIEPTTGQIVLKN 1075
             ..|...:....|...|..|                                    |:.||:.:.
  Rat   865 -SQPSVTKKTREGVSADSAA------------------------------------TSHQIIFQK 892

  Fly  1076 QVNPKNNKPDKDYARIISLRIVQQRVDPATKAPITEVSASKDKDIVVDPKSNQIWVPTGATDPAT 1140
            .| |...:..:|:  :|..:|..:.||..:|..:|.      |.:.|..|:.:|        ||
  Rat   893 SV-PSTLEGTEDW--VIVDKIPTEVVDGDSKKIVTY------KVVTVSSKTGEI--------PA- 939

  Fly  1141 KEQQYISSSVDPKTGYVITIYGYLD-PKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGE 1204
                      |.....::.:||:.| .:..::|::.|            .|:||.....|..:|
  Rat   940 ----------DLLKSGMVDMYGFDDLAREMQLKEENK------------QKVYTLGKSYDTVSG- 981

  Fly  1205 PLYAATQVDPESGEVYTKLARVDPKTGKIVIVRILLISKTDERGRPEEIDPSTCE----IDPVSG 1265
                                |:...|||         :|..||| |:   |||.|    ::..:.
  Rat   982 --------------------RIVTMTGK---------AKDSERG-PQ---PSTLEGLQKMESGAS 1013

  Fly  1266 RVLKFFNKTVYVYNMIDPVTGEIVQVDPNDPRFAGARTTVTHTMTLTGEIDPVTGRIKSEYGDID 1330
            ..|:           :.|:..|...::....:...|....|....|:..:.|:.   ::|.....
  Rat  1014 EALR-----------VGPLLVEYEVLEALTEKSGRAPEVQTPKRRLSESLAPIK---EAESRRQS 1064

  Fly  1331 PNTGDIDPATAVTDPVTGKLILNYAQIDPSHFGKQAQVQTTTETVPITRQQFFDGVKHISKGALR 1395
            |...|...|..:.:..            |:|. :.::.|...|...:....|....|.:|:....
  Rat  1065 PEEDDTQKAPKLGEDA------------PAHL-RSSKTQQVPECEVLKVGPFGPRRKSLSEWRYS 1116

  Fly  1396 RD-----------SEGSSDDDMTAQYGADQV---NEIL-----IGSPAGQAGGKLGKPVSTPTVV 1441
            |:           :|.|:...:|.|...:::   :|||     ...|....||           |
  Rat  1117 REPAFTVATAHYVTESSASQVVTKQSSGEKLMDGSEILSLLESARKPTEFIGG-----------V 1170

  Fly  1442 KTTTKQVLTKNIDGVTHNVEEEV------RNLGTGEVTYST----QEH------KADATPTDLSG 1490
            .:||:..:.| ::..|..:|.||      :.|.|.:|...|    :.|      ..||:.|....
  Rat  1171 SSTTQSWVQK-LETKTETIETEVEPTPHPQPLSTEKVLQETVLVEERHVMNVHASGDASHTARDD 1234

  Fly  1491 AYVTATAVTTRTATTHEDLGK--NAKTEQLEEKTVATTRTHDPNKQQQRVVTQEVKTTATVTSGD 1553
            ...|.:|...|    |...||  ::.||..:|:.........|.::|...|:||....:.:.|.:
  Rat  1235 VDATESAPADR----HSGNGKEGSSVTEAAKEQRGEEADKSAPEQEQPATVSQEEDQVSAIHSSE 1295

  Fly  1554 QYQRRDSVSSTSSGDSGTPIDGPYDGASVVRTDNQKSPLFTTSATTGPHVESTRVVLGED-TPGF 1617
            ..:::....|::.......:.....|...:.|..::.|:..|...|..: ||::|..|.| .||.
  Rat  1296 GLEQKSHFESSTVKVESISVGSVSPGGVKLETSTKEVPVVHTETKTITY-ESSQVDPGADLEPGV 1359

  Fly  1618 SGHGEIISTQTVSSKTRTVETITY--KTERDGIVETRVEQKITIQSDGDPIDHDKALAEAIQEAT 1680
                 ::|.||::|:|.:..|.|:  ||.:.||.|||:|::|.|..|.| ||||:|||:||:||.
  Rat  1360 -----LMSAQTITSETTSTTTTTHITKTVKGGISETRIEKRIVITGDAD-IDHDQALAQAIKEAK 1418

  Fly  1681 AMNPDMTVEKIEIQQQTQ 1698
            ..:|||:|.|:.:.::|:
  Rat  1419 EQHPDMSVTKVVVHKETE 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	110/189 (58%)
		FERM_N	36..98	CDD:286467	27/61 (44%)
		FERM_M	116..224	CDD:278785	73/107 (68%)
		FERM_C_4_1_family	219..312	CDD:270005	81/92 (88%)
		FA	323..363	CDD:285894	16/41 (39%)
		PQQ_2	829..>972	CDD:290097	14/149 (9%)
		4_1_CTD	1612..1698	CDD:283537	38/88 (43%)
Epb41l3	XP_038938840.1	B41	135..324	CDD:214604	110/189 (58%)
		FERM_C_4_1_family	319..412	CDD:270005	81/92 (88%)
		FA	421..464	CDD:400882	16/42 (38%)
		SAB	775..823	CDD:398195	12/127 (9%)
		4_1_CTD	1331..1436	CDD:399118	45/111 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345161
Domainoid	1	1.000	168	1.000	Domainoid score	I3725
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1131
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm45774
orthoMCL	1	0.900	-	-		OOG6_101605
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750