DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cora and epb41l4b

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_005158090.1	Gene:	epb41l4b / 100332627	ZFINID:	ZDB-GENE-100921-92	Length:	729	Species:	Danio rerio

Alignment Length:	703	Identity:	187/703 - (26%)
Similarity:	299/703 - (42%)	Gaps:	133/703 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SSSHGKPAL-ARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLD 88
            ::.:.|.|: .||.|||||.::|.:.:.|.|:|:.:.|...|:|:|.|||||.:..|.....|||
Zfish    60 AAGNSKDAITCRVLLLDGSDVNVELPKHAKGQDLFDQIMYHLDLVEADYFGLQFMDPEQVAHWLD 124

  Fly    89 LEKPVSKFFR-TDTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGS 152
            ..||:.|..| ...:.|.|.||||..||:.|.|:.|||...||:|.|||.|:|.|.:.....||:
Zfish   125 AAKPIKKQIRHGPPYRLFFRVKFYSSEPNNLHEEFTRYLFVLQLRQDILSGKLKCPYDVSVELGA 189

  Fly   153 YLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLA 217
            |.:|||:||.|..| .:...:.:|:.:|.||..:|..:.......:|..|::|||::|...|.|.
Zfish   190 YCLQSELGDCDPLE-HSILLVSEFRFSPKQTEIMEADIYRKWVECRGMIPSQAELNFLNKCKWLE 253

  Fly   218 MYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFE-- 280
            |||||:|..|..:|.:..||:..:|:||:....:|..|.||||.::.:||:...:.:...:.:
Zfish   254 MYGVDMHFVKGRDGGEYALGLTPTGILVFEGSSKIGLFFWPKITRLDFKRNRLTLVVVEDDEKGR 318

  Fly   281 QYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKM-FPVFGSTYRYKGRTQAESTNT 344
            :.|.|..|:|::....|.|||..||.|.||||..|.....|:. |...||.:|:.|||:.::|::
Zfish   319 EQEHTFVFQLSSSHECKHLWKCAVESHAFFRLRQPTHNKTSRSDFTRLGSRFRFSGRTEYQATHS 383

  Fly   345 PVDRTPPKFNRTLSGARLTSRS---MDALALAEKEKVARKS----STLDHRGDRNADGDAHSRS- 401
            ...|....|.|..| .|..||:   :.|:..|:...::.::    |...::.:.....|...||
Zfish   384 GKVRRASTFERRPS-KRYPSRAQSMVKAMTPAKHPHLSAQTSPEPSLKPYKHNIPIAQDPWQRSH 447

  Fly   402 -------------------------PIK-------NKKEKDADKEAKLREKKQKEKEEKER---- 430
                                     |:.       :.:|.:|....|:.........||:.
Zfish   448 PPPSLTSPLYIQPMELGHTPPPHSFPLSAADTRRFSVEENEAPHSGKIHRCYHHHGYEKQEPLCL 512

  Fly   431 --------------KEREKRELEEKKKAEKAAKAALAAGAAAGAAVNGNDELNDSNKSDKSSG-- 479
                          .:...|.|:.:.:||.||..||...      ::..:|...|.||..||.
Zfish   513 TTAKPKAWVVSPALSDELDRALQNQLEAEPAAWPALHIN------IDMAEEKPLSEKSLPSSPAV 571

  Fly   480 -RRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQNLDEAARNAAKN 543
             :..:....|.|.::|.|.:..|...||...|:            ...:.||..  .::.|..|.
Zfish   572 LQEQLKSNISKRATQSDSGNSKGNSSSGDQTDR------------YPSSSQDSG--SSSLNIEKP 622

  Fly   544 RGSTTPGVTRQYEYAVDNDGNTSPTRKSYTPGGFRYDQDPNSRKSGADGQEQLSPTSQQKKIGLA 608
            |......:.||:.:      |.|             |:|        |..|.|:..|.|..:|
Zfish   623 RVDRRKRLVRQFSF------NHS-------------DED--------DLPEALAAISSQCSMG-- 658

  Fly   609 FNYAPGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLLQDPLLSPT 661
                   :::...:.:|.....:.|..:|         .||.:....||..|:
Zfish   659 -------KSSSNSSLDKQVQPPIYPPQKD---------TSRLEHDSSPLFFPS 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	78/190 (41%)
		FERM_N	36..98	CDD:286467	26/61 (43%)
		FERM_M	116..224	CDD:278785	42/107 (39%)
		FERM_C_4_1_family	219..312	CDD:270005	33/94 (35%)
		FA	323..363	CDD:285894	13/40 (33%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
epb41l4b	XP_005158090.1	B41	69..260	CDD:214604	78/191 (41%)
		FERM_N	72..134	CDD:286467	26/61 (43%)
		FERM_M	153..260	CDD:278785	42/107 (39%)
		FERM_C_NBL4_NBL5	256..349	CDD:270007	31/92 (34%)
		FA	362..402	CDD:285894	13/40 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740