DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cora and frmd3

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_002663277.2	Gene:	frmd3 / 100331256	ZFINID:	ZDB-GENE-070523-1	Length:	603	Species:	Danio rerio

Alignment Length:	422	Identity:	150/422 - (35%)
Similarity:	228/422 - (54%)	Gaps:	25/422 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSKFFR-T 99
            |.|||.|.:..||.|...|:.:::.:|...:|:||||||:.|..|...|.|||..|||.|..: .
Zfish    22 VRLLDDSEISCSIQRDTKGQFLVDHVCNHYSLLEKDYFGIRYVDPDKQRHWLDPSKPVVKQMKCQ 86

  Fly   100 DTWPLTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEMGDYDA 164
            ..:.:.|.|||||.||.::||::|||.|.||::.|:..|||.|.|...|.||:.:||:|:||||.
Zfish    87 QPYTMCFRVKFYPQEPIKIKEELTRYLLYLQLKRDVYHGRLLCPFADAAYLGACIVQAELGDYDP 151

  Fly   165 EEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTH-KGQSPAEAELHYLENAKKLAMYGVDLHPAKD 228
            ||.|. .|:.|||:.|.|:.:||.|:|::|:.. :||.|:.|||:.|:.|..|..||||.||.||
Zfish   152 EEHPA-DYISDFKLFPKQSLKLERKIMEIHQNELRGQCPSLAELNLLQRAHTLDTYGVDPHPCKD 215

  Fly   229 SEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTIGFKLANH 293
            ..|....||..|.|.:|::...||:...|..:.|..::...||:   .|...:.:..:.|..:..
Zfish   216 FTGSTAFLGFTARGFVVFQGNKRIHLLKWADVSKFKFEGKTFYV---IGVQREKKLVLTFHTSTP 277

  Fly   294 RAAKKLWKSCVEHHTFFRLMTP---EPVSKSKMFPVFGSTYRYKGRTQAE--STNTPVDRTPPKF 353
            .|.|.|||..||:..|::....   :.||.|.:| ..||.:||.||...|  ..::.:.|.||..
Zfish   278 AACKHLWKCGVENQAFYKCAKSSQIKTVSSSSIF-FKGSRFRYSGRVAKEVIEASSKIQRDPPVV 341

  Fly   354 NRTLSG--ARLTSRSMDALALAEKEKVARKSSTLDHRGDRNADG------DAHSRSPIK-NKKEK 409
            :|...|  ...||.|...|.:..:..:...||:.:.| |.:||.      |....||:| :...:
Zfish   342 HRCQFGQSRSFTSLSHKQLIMNMEPLLPALSSSRESR-DSSADNGLSALKDCVHLSPLKPSVTPE 405

  Fly   410 DADKEAKL---REKKQKEKEEKERKEREKREL 438
            :|:.|..|   :|:::.|..::.|.:.::||:
Zfish   406 EAEMEEMLNFSQERREDEASQRTRVDEDRREI 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	86/189 (46%)
		FERM_N	36..98	CDD:286467	27/61 (44%)
		FERM_M	116..224	CDD:278785	51/108 (47%)
		FERM_C_4_1_family	219..312	CDD:270005	30/92 (33%)
		FA	323..363	CDD:285894	13/43 (30%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
frmd3	XP_002663277.2	B41	20..211	CDD:214604	86/189 (46%)
		FERM_N	22..85	CDD:286467	27/62 (44%)
		FERM_M	104..211	CDD:278785	51/107 (48%)
		PH-like	192..295	CDD:302622	36/105 (34%)
		FA	310..356	CDD:285894	15/46 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910