DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and epb41

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_017947008.1	Gene:	epb41 / 100038195	XenbaseID:	XB-GENE-481625	Length:	935	Species:	Xenopus tropicalis

Alignment Length:	553	Identity:	233/553 - (42%)
Similarity:	318/553 - (57%)	Gaps:	85/553 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAEIKPSAPAEPETPTK--------SKPKSSSSSHGKPAL------ARVTLLDGSLLDVSIDRKA 52
            ||:.:.....:||...:        .||:..|.:..|...      .:|||||.::.:..:::.|
Frog   167 PAQEEQKEDQDPEADCEDVEGKEQIKKPEGESKASQKVVRRSTNMHCKVTLLDDTVYECDLEKHA 231

  Fly    53 IGRDVINSICAGLNLIEKDYFGLT-YETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVKFYPPEPS 116
            .|:|:...:|:.||::|:|||||. :|:|| .:.|||..|.:.|.........||.||||||:|:
Frog   232 KGQDLFKKVCSHLNILEEDYFGLALWESPT-CKVWLDPLKDMRKQVHGGPCEFTFNVKFYPPDPA 295

  Fly   117 QLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLKDFKIAPN 181
            ||.||||||:||||:|.||..|.|||:|.|.||||||.||||:|||: |::....|:.:||::||
Frog   296 QLSEDITRYYLCLQLRKDIFSGCLPCSFATLALLGSYTVQSEVGDYE-EDLHGVDYVNEFKLSPN 359

  Fly   182 QTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVY 246
            ||.:||:||::|||:::..:||:|:|.:|||||||.|||||:|.|||.|||||.||||:.||:|:
Frog   360 QTKDLEEKVVELHKSYRSMTPAQADLEFLENAKKLTMYGVDIHQAKDLEGVDIKLGVCSGGLMVF 424

  Fly   247 RDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFR 311
            :|.||||||.|||:|||||||..|:|||||||.|||||||||||.:::|||||||.|||||||||
Frog   425 KDNLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYKAAKKLWKVCVEHHTFFR 489

  Fly   312 LMTPEPVSKSKMFPVFGSTYRYKGRTQAESTNTP--VDRTPPKFNRTLSGARLTSRSMD------ 368
            |.:.|.:.|.: |...||.:||.|||||::.:..  :||..|.|.||  |::..|||:|
Frog   490 LTSTESIPKHR-FLSLGSKFRYSGRTQAQTRHASALIDRPAPNFVRT--GSKRASRSLDGAKRGH 551

  Fly   369 ----------------ALALAEK-----------EKVARKS--STLDHRGDRNADGDAHSRSPIK 404
                            |..:.:|           ||:..::  |..||:.....|||  ...||.
Frog   552 VSVQFHNLEDAENVMEAFEVEDKKQSIPTVIFYPEKIIMENNDSDDDHKLKSKRDGD--ELIPIG 614

  Fly   405 NKKEKD----ADKEAKLREK-------KQKE---------KEEKERKEREKRELEEKKK------ 443
            :||.|.    |..||....:       .|:|         |....|.|...|::|||.|
Frog   615 HKKRKQPAAVATPEASRSHRPVSAPVFPQREVITQPVAQRKTPVPRAEEMPRKIEEKSKERVPNQ 679

  Fly   444 AEKAAKAALAAGAAAGAAVNGNDELNDSNKSDK 476
            .|......:....:....|||:.....:.|.|:
Frog   680 RESPEDVKVTQQDSPSPTVNGDQVKQQAEKEDE 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	99/190 (52%)
		FERM_N	36..98	CDD:286467	25/62 (40%)
		FERM_M	116..224	CDD:278785	65/107 (61%)
		FERM_C_4_1_family	219..312	CDD:270005	71/92 (77%)
		FA	323..363	CDD:285894	17/41 (41%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
epb41	XP_017947008.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I3854
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1111
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm48868
Panther	1	1.100	-	-	O	PTHR23280
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.150