DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and OXSR1

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_011532633.1	Gene:	OXSR1 / 9943	HGNCID:	8508	Length:	580	Species:	Homo sapiens

Alignment Length:	386	Identity:	138/386 - (35%)
Similarity:	192/386 - (49%)	Gaps:	55/386 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GSGTYGDVYKAKRIQSNELAAIKVIKLEP-SDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKL 96
            |||....|..|......|..|||.|.||. ...:..:.:||..|..|.||||::||.|::.:|:|
Human    77 GSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDEL 141

  Fly    97 WICMEFCGGGSLQDIYQ--------VTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANIL 153
            |:.|:...|||:.||.:        .:|.|.|..||.:.||.|:||||||..|::|||:|..|||
Human   142 WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNIL 206

  Fly   154 LTEYGDVKLADFGVSAQITA----TINK-RKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGIT 213
            |.|.|.|::|||||||.:..    |.|| ||:|:|||.||||||  :|:..||:...|||:.|||
Human   207 LGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEV--MEQVRGYDFKADIWSFGIT 269

  Fly   214 AIELAELQPPMFDLHPMRALFLMSKSGFKPPTL----NNKD---KWSPTFHNFIKTALTKNPKKR 271
            |||||....|.....||:.|.|..::  .||:|    .:|:   |:..:|...|...|.|:|:||
Human   270 AIELATGAAPYHKYPPMKVLMLTLQN--DPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKR 332

  Fly   272 PTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVP 336
            |||..||:|.|.|...:    ||.||                |:::...|  ..|:...:...||
Human   333 PTAAELLRHKFFQKAKN----KEFLQ----------------EKTLQRAP--TISERAKKVRRVP 375

  Fly   337 AQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQY----IDEELKLRATLPLNNDTKDPLG 393
            ..:..|.........|::.....|:.....::.|.    :.|.:......|    |.||:|
Human   376 GSSGRLHKTEDGGWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFP----TTDPVG 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	117/270 (43%)
		S_TKc	26..283	CDD:214567	117/270 (43%)
		CNH	869..1184	CDD:279162
OXSR1	XP_011532633.1	STKc_OSR1_SPAK	77..344	CDD:270787	117/270 (43%)
OXSR1	XP_011532633.1	S_TKc	77..344	CDD:214567	117/270 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910