Protein Alignment hppy and MAP4K4

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_001381931.1
• Gene: MAP4K4 / 9448
• HGNCID: 6866
• Length: 1384
• Species: Homo sapiens
• Alignment Length: 1448
• Identity: 333/1448 - (22%)
• Similarity: 538/1448 - (37%)
• Gaps: 491/1448 - (33%)

  Fly    11 NMLSSDISR-RNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIM 74
            :::..|:|. |:|...:||::.:|:||||.|||.:.:::.:||||||:.: ..|:.:.|:.||.|
Human     9 SLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV-TEDEEEEIKLEINM 72

  Fly    75 MRD-CRHPNIIAYYGSYLRR------DKLWICMEFCGGGSLQDIYQVT--GPLTEVQIAYMCRET 130
            ::. ..|.||..|||:::::      |:||:.|||||.||:.|:.:.|  ..|.|..|||:.||.
Human    73 LKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137

  Fly   131 LKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAV 195
            |:||.:||....:||||||.|:||||..:|||.|||||||:..|:.:|.:||||||||||||.|.
Human   138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAC 202

  Fly   196 ERK--GGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHN 258
            :..  ..|:...|:|:|||||||:||..||:.|:||||||||:.::  .||.|.:| |||..|.:
Human   203 DENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK-KWSKKFFS 264

  Fly   259 FIKTALTKNPKKRPTAERLLQHPFV-------QCEMSLRVAKELLQKYQSPNPQFYYYLDGDEES 316
            ||:..|.||..:||:.|:||:|||:       |..:.|:...:..:|.:....:..|...|.||.
Human   265 FIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEE 329

  Fly   317 VAGVPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSS--PETLPSDMSL----------- 368
            ...||:: ..:.:|..| ||.::...:..:.......|||.:  .:.|..:..|
Human   330 EEEVPEQ-EGEPSSIVN-VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLL 392

  Fly   369 ----------------------------------------------------------------- 368
                                                                             
Human   393 AERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457

  Fly   369 -------LQYI----DEELKLRATLPLNNDTKDPLGAEC---SCSSHNGGAAGGGGGGGVGVGAG 419
                   .:||    :||.:....|......:..:..||   ....|.
Human   458 KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHR----------------- 505

  Fly   420 GAAANGSSSSSGGATVGTTHHQHQQHH------QHHH---HPNHLHQHQSHQLPQQQQQQS---- 471
                          .......|.||..      ||.|   ||.|     |.|.|..||::|
Human   506 --------------QAERLQRQLQQEQAYLLSLQHDHRRPHPQH-----SQQPPPPQQERSKPSF 551

  Fly   472 HQAAQQEHH-----------------HHHPMTSSISSGL-----VTANANNISSSASLASMPGLS 514
            |....:.|:                 |..|...|..:|.     |.:.:.:.|:..|.:..|.|.
Human   552 HAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQ 616

  Fly   515 ---------AYLG---------MRSHVVGHMGMGFGMG---------------LGMSN------- 539
                     ::|.         .|||........|...               |..|:
Human   617 RPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQDPCPPSRSEVLSQSSDSKSEAP 681

  Fly   540 --------------------LRTTS----IDADDDELVA-----ADVAMNNAAAAV--------- 566
                                :||||    :...|..|..     :.....|:.:::
Human   682 DPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERV 746

  Fly   567 ------PGNGSGAGN-------GSGSGCSASAAHYLRYSSNYRS--------------------- 597
                  ||:||.:|:       ||..|..:.:....|..|:.:|
Human   747 EKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEV 811

  Fly   598 ------------AAAAQASQAAH----PH----VNSNS-------------------NSNNGHGH 623
                        .|.|:..:|..    ||    .:|:|                   .|.:|...
Human   812 FRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPED 876

  Fly   624 APITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGGS-----SNISSSGGASSGTNGLLDKHE 683
            ....||::.|.........:::.|:...:..:..:..|:     |.:.....:...:||...:..
Human   877 TRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQSTVDQKRASHHESNGFAGRIH 941

  Fly   684 L--DALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGS 746
            |  |.|.|          |||:|.::.|     .|..:..|:.:.|....|:.|  ::.||.:.|
Human   942 LLPDLLQQ----------SHSSSTSSTS-----SSPSSSQPTPTMSPQTPQDKL--TANETQSAS 989

  Fly   747 SSAGNNCDYRHENNQNG--------LEDSPRRHSSMDQLIGLLENMGKSPRTRSLSDGGTQDDDE 803
            |:.     .:|:::.:.        |:.||...:::..::|.            ..||...:...
Human   990 STL-----QKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGF------------SCDGMRPEAIR 1037

  Fly   804 AEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASW 868
            .:...:..::|..|            |..||.|:    ||::..   :.|.||.   .:.|.|.|
Human  1038 QDPTRKGSVVNVNP------------TNTRPQSD----TPEIRK---YKKRFNS---EILCAALW 1080

  Fly   869 IHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFP----RRTTWLYVIK--DVLMSLSGKSCQL 927
                  ..:||:|.|.|:..|:.     :...:::|    ||...:.|::  :||:::|||..:|
Human  1081 ------GVNLLVGTESGLMLLDR-----SGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKL 1134

  Fly   928 YRHDLVALHSKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATP 992
            ..:.|..|.:|     .||.:  ||  |.:|...|| |.|.:.|....|.:  |...|:|..|..
Human  1135 RVYYLSWLRNK-----ILHND--PE--VEKKQGWTT-VGDLEGCVHYKVVK--YERIKFLVIALK 1187

  Fly   993 SGIFLMQWY-DPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIITPELEYPIVCTGVRKA 1056
            |.:.:..|. .|.:|||..|.                      ..|::..|.|....|..|.|
Human  1188 SSVEVYAWAPKPYHKFMAFKS----------------------FGELVHKPLLVDLTVEEGQR-- 1228

  Fly  1057 MNGCLKLELINMNSASWFHSEDLE----YDA-------------MATMVPRRDLLKVVRVHQVEK 1104
                  |::| ..|.:.||:.|::    ||.             ...::|..|.::::..:  |.
Human  1229 ------LKVI-YGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCY--ED 1284

  Fly  1105 DAILV-CYGNLIQVVTLQ 1121
            :.:.| .||.:.:.|.||
Human  1285 EGVYVNTYGRITKDVVLQ 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	130/268 (49%)
		S_TKc	26..283	CDD:214567	130/267 (49%)
		CNH	869..1184	CDD:279162	65/278 (23%)
MAP4K4	NP_001381931.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910