Protein Alignment hppy and KIC1

DIOPT Version :10

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_011970.1
• Gene: KIC1 / 856502
• SGDID: S000001144
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 905
• Identity: 229/905 - (25%)
• Similarity: 372/905 - (41%)
• Gaps: 201/905 - (22%)

  Fly    26 YELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLE-PSDDIQIIQQEIIMMRDCRH-PNIIAYYG 88
            ::..:.||.|.:|.|||...:::..:.||||:.|: .||:::.:|:||..:...:. .||..|||
Yeast    23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYG 87

  Fly    89 SYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANIL 153
            |||:...|||.||.|.||||:.:.: .|.:.|..|..:.||.|..|:.:|....:|||||.||:|
Yeast    88 SYLKDTSLWIIMEHCAGGSLRSLLR-PGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVL 151

  Fly   154 LTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELA 218
            :|..|:|||.||||:||:..|..:|::..||||||||||  :.....|:...|||:.|||..|:|
Yeast   152 ITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEV--IMEGVYYDTKVDIWSLGITTYEIA 214

  Fly   219 ELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFV 283
            ...||..|:..:||:.|:.||  |||.|.:: .:|.:...||...|.::||:|.:|:.||:..|:
Yeast   215 TGNPPYCDVEALRAMQLIIKS--KPPRLEDR-SYSTSLKEFIALCLDEDPKERLSADDLLKSKFI 276

  Fly   284 QCEMS--LRVAKELLQKY-----QSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQN-- 339
            :...:  ..:.|||:.:|     ::.|.   |.::|      .:|:...||.:....  |:||
Yeast   277 RAHKATPTSILKELISRYLLFRDKNKNK---YKIEG------SIPENEPSKPSEAPK--PSQNGG 330

  Fly   340 -HTLKTGMTTNSTWNERSSSPET-LPSDMSLLQ----YIDEELKLRATLPLNNDTK--------- 389
             ...:..:.:|....:|.:..:. :..|...|.    .|:..:.|.|....||:..
Yeast   331 GDEAQKSIASNDNEIKRVNEGDVEMKWDFDSLSSSDYIIENNINLDALAEDNNEWATAQHDLFNY 395

  Fly   390 ----------DPLGAECSCSSHN-------GGAAGGGGGGGVGVGAGGAAAN------------- 424
                      ||       :|||       |...|.|..|.:   |..:..|
Yeast   396 AYPDEDSYYFDP-------TSHNTRPFVYQGTTIGKGYPGTI---AQNSTLNAPVTNNYTNSKYP 450

  Fly   425 -----GSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQQQQQSHQAAQQEHHHHHP 484
                 |::::||..|.|.....           ..|......||.:..:......|:.:.:...|
Yeast   451 SKMVAGTTNTSGTHTAGPMTSS-----------KRLESKAPKQLLELFEDNEIITAENDVNTEAP 504

  Fly   485 MTSSISSGLVTANAN--------------NISSSASLASMPGLSA---YLGMRSHVVGHMGMGF- 531
            ..|...|.|...|::              ||:::.....:|.||:   |....:..:..:...|
Yeast   505 KISKSISSLNAGNSSRDDFIPSISNEVNGNINNNKMRPHLPPLSSGNNYYSQSTPALPLLQTKFN 569

  Fly   532 --GMGLGMSNLRT--TSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYS 592
              ..|...|.|.|  |||:.:..|      .:.|:|...|               |||...|..|
Yeast   570 KTSKGPPTSGLTTAPTSIEIEIPE------ELPNSALPTP---------------ASADPVLIPS 613

  Fly   593 SNYRSA--AAAQASQAAHPHVNSNSN-------SNNGHGHAPIT-------------SSISSSAS 635
            :..||:  .|...|.::.....|.||       |||...|.|.|             |.|||:.:
Yeast   614 TKARSSTVTAGTPSSSSSIQYKSPSNVPRRLTVSNNRPEHCPSTITNQKLGSAVASNSGISSTPN 678

  Fly   636 SASFYNRLLLLDNSSGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQ----------- 689
            :::.||     :|:..:...|.:|..::|.:..|..:.|....|..|:..:..:
Yeast   679 NSNNYN-----NNTDSENSRGSSGSNTANSTQMGITNPGNVTKLSTHKASSPSRPLFGVGTSPNR 738

  Fly   690 ----AATKSAGDGFSHSN---SPTANSGAGATGSRD------NDGPSSSNSSHLYQNLLRSSSGE 741
                :.|::.|...:|:|   .||....|.:..::|      |..||||..:.:..|...:.:..
Yeast   739 KPAGSPTQNIGHNSTHTNLAPPPTMKPMANSKDNKDILLQPLNSIPSSSTLNTISGNSSNNLTSS 803

  Fly   742 TPAGSSSAGN--NCDYRHENNQNGLEDSPR-----RHSSMDQLIGLLENMGKSPRTRSLS 794
            ....:...|:  |.|:: .||.|.....|.     |:..:|......:|....|.:..:|
Yeast   804 NYFSNEKEGSRVNGDFK-RNNPNLKLQMPLPTPVVRNKLLDPNTATSQNNNGMPGSAGIS 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	105/258 (41%)
		CNH	864..1193	CDD:470577
KIC1	NP_011970.1	STKc_NAK1_like	21..295	CDD:270822	109/277 (39%)