DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and ATMAP4K ALPHA1

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001185209.1	Gene:	ATMAP4K ALPHA1 / 841750	AraportID:	AT1G53165	Length:	688	Species:	Arabidopsis thaliana

Alignment Length:	766	Identity:	234/766 - (30%)
Similarity:	351/766 - (45%)	Gaps:	149/766 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPS-DDIQIIQQEIIMMRDCRHPNIIAYYG 88
            ::||   ||.|::||||||...:.|:..|||||.||.| |:|:.||:||.::..||.|.|..|||
plant    17 QFEL---IGRGSFGDVYKAFDTELNKDVAIKVIDLEESEDEIEDIQKEISVLSQCRCPYITEYYG 78

  Fly    89 SYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANIL 153
            |||.:.||||.||:..|||:.|:.|...||.|:.||.:.|:.|..:||||:.||:|||||.||||
plant    79 SYLHQTKLWIIMEYMAGGSVADLLQPGNPLDEISIACITRDLLHAVEYLHAEGKIHRDIKAANIL 143

  Fly   154 LTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELA 218
            |:|.||||:||||||||:|.||::||:|:|||:||||||  ::...|||:..|||:.|||.||:|
plant   144 LSENGDVKVADFGVSAQLTRTISRRKTFVGTPFWMAPEV--IQNSEGYNEKADIWSLGITMIEMA 206

  Fly   219 ELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFV 283
            :.:||:.||||||.||::.:.  .||.|:  :.:|.....|:...|.|.|.:||.|:.||:|.|:
plant   207 KGEPPLADLHPMRVLFIIPRE--SPPQLD--EHFSRPLKEFVSFCLKKAPAERPNAKELLKHRFI 267

  Fly   284 QCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNG--VPAQNHTLKTGM 346
            :   :.|.:.:||::.:. .|:  |.:..|||    :|          |||  .||::    :|
plant   268 K---NARKSPKLLERIRE-RPK--YQVKEDEE----IP----------TNGPKAPAES----SG- 307

  Fly   347 TTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGGGG 411
            |.....:||...    .|...|.:::|:..:::..                   .|.|.....||
plant   308 TVRVAKDERGQG----TSGTRLDKWLDKCFQVKTV-------------------RNAGWDFSIGG 349

  Fly   412 GGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQ---------- 466
                             |.|..||........:..:...:.|...|..|.....|
plant   350 -----------------SQGAGTVRALKPPQARERRQEVNSNQTSQKTSRTSGSQLSSTFGVPEI 397

  Fly   467 -----QQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASL--ASMPGLSAYLGM----R 520
                 .::.|:|...||.      ..|..||.|...:...|.|:|:  ....|.:.|...    .
plant   398 SEGGFNKRDSYQNDYQEE------DDSSGSGTVVIRSPRSSQSSSMFRDQSSGSTRYTSFDDAST 456

  Fly   521 SHVVGHMGMGFGMG--------LGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNG-SGAGNG 576
            |..|...|.....|        ||:....:::.:.....|..|.:|:.  |....||. ...|||
plant   457 SGTVVVRGQNDDSGSPRTPRSRLGLQERSSSASEDSISNLAEAKLALE--AGFRRGNARERLGNG 519

  Fly   577 SGSGCSASA---AHYLRYSSNYRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSAS 638
            ..:.....|   :.|||.|.::        |....|.:.|...|::....:.: :|:|:|.|
plant   520 KVNKRREQATDNSDYLRNSRDH--------SDKQRPVMRSQQVSDDEEDDSKL-ASLSASLS--- 572

  Fly   639 FYNRLLLLDNSSGDAVVGGNGGGS--SNISSS---------GGASSGTNGLLDKHELDALPQAAT 692
                 |||..|..:||.|.:..|:  ..:|.|         |.:.:....|::  :|.:..:.:.
plant   573 -----LLLLPSLKEAVGGDDSKGTIGHRVSRSLVKMEREKPGSSEAFIAKLIE--QLGSTKEVSV 630

  Fly   693 KSAGDGFSHSNSPTANSGA-GATGSRDNDGPSSSNSSHLYQNLLRSSSGET 742
            |...|......:.|.|:.| ........:..|::|.|.|.:.|.....|:|
plant   631 KEVQDMAIRVFAKTMNNDAENKRKQASKEFSSNANFSPLARFLFSRWLGQT 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	134/258 (52%)
		S_TKc	26..283	CDD:214567	134/257 (52%)
		CNH	869..1184	CDD:279162
ATMAP4K ALPHA1	NP_001185209.1	STKc_MST3_like	14..287	CDD:270786	139/284 (49%)
ATMAP4K ALPHA1	NP_001185209.1	S_TKc	19..267	CDD:214567	134/256 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010