DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and AT4G24100

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001328320.1	Gene:	AT4G24100 / 828510	AraportID:	AT4G24100	Length:	725	Species:	Arabidopsis thaliana

Alignment Length:	814	Identity:	202/814 - (24%)
Similarity:	324/814 - (39%)	Gaps:	184/814 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEP-SDDIQIIQQEIIMMRDCRHPNII 84
            ||:| |:|:::||.|....||:|..:.:||:.|||.:.|:. :.::..|::|...|....|||:|
plant    45 NPKD-YKLMEEIGHGASAVVYRAIYLPTNEVVAIKCLDLDRCNSNLDDIRRESQTMSLIDHPNVI 108

  Fly    85 AYYGSYLRRDKLWICMEFCGGGSLQDIYQV--TGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDI 147
            ..:.|:.....||:.|.|...||...:.:.  :....|..|..:.:||||.|:|||..|.:|||:
plant   109 KSFCSFSVDHSLWVVMPFMAQGSCLHLMKTAYSDGFEESAICCVLKETLKALDYLHRQGHIHRDV 173

  Fly   148 KGANILLTEYGDVKLADFGVSAQITATINK---RKSFIGTPYWMAPEVAAVERKGGYNQLCDIWA 209
            |..||||.:.|::||.||||||.:....::   |.:|:|||.||||||  ::...|||...|||:
plant   174 KAGNILLDDNGEIKLGDFGVSACLFDNGDRQRARNTFVGTPCWMAPEV--LQPGNGYNSKADIWS 236

  Fly   210 CGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLN-NKD-KWSPTFHNFIKTALTKNPKKRP 272
            .||||:|||....|.....||:.|.:..::.  ||.|: ::| |:|.:|...:...|.|:..|||
plant   237 FGITALELAHGHAPFSKYPPMKVLLMTIQNA--PPGLDYDRDKKFSKSFKEMVAMCLVKDQTKRP 299

  Fly   273 TAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPA 337
            |||:||:|   .|....:..::.::...|..|..:..:...::..|   |::|.|..:..:....
plant   300 TAEKLLKH---SCFKHTKPPEQTVKILFSDLPPLWTRVKSLQDKDA---QQLALKRMATADEEAI 358

  Fly   338 QNHTLKTGMTTNSTWN----ERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSC 398
            .....:.|:   |.||    :..:....|..|..|.:..::|..|.|.....||.:....:....
plant   359 SQSEYQRGV---SAWNFDVRDLKTQASLLIDDDDLEESKEDEEILCAQFNKVNDREQVFDSLQLY 420

  Fly   399 SSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQL 463
            .:.||...           .........:.......|.||....:.      .||     ..|.:
plant   421 ENMNGKEK-----------VSNTEVEEPTCKEKFTFVTTTSSLERM------SPN-----SEHDI 463

  Fly   464 PQQQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMG 528
            |:.:.:              |:.....||.:|:. ..:|.|||            .:||:
plant   464 PEAKVK--------------PLRRQSQSGPLTSR-TVLSHSAS------------EKSHI----- 496

  Fly   529 MGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSS 593
                            .:..:.|...|.......:.      ||..|.|....|.|.:..::||.
plant   497 ----------------FERSESEPQTAPTVRRAPSF------SGPLNLSTRASSNSLSAPIKYSG 539

  Fly   594 NYRSAAAAQASQAAHPHVNSNSNSN-NGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGG 657
            .:|.:            ::..|.:| ...|...:||.....|.....             ::|..
plant   540 GFRDS------------LDDKSKANLVQKGRFSVTSGNVDLAKDVPL-------------SIVPR 579

  Fly   658 NGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGP 722
            ....::.:..|  ||.| |.:|:.....|.||...:       ||:.||::|            |
plant   580 RSPQATPLRKS--ASVG-NWILEPKMPTAQPQTIKE-------HSSHPTSSS------------P 622

  Fly   723 SSSNSSHLYQ----------NLLRSSSGETPAGSSSAGNNCDYRHENNQNG-LEDSPRRHSSMDQ 776
            ......||:|          |||.|..   |..::          |.:|:| |...||..|:
plant   623 IMPQLQHLFQQNSIQQDLIMNLLNSLQ---PVEAT----------EGSQSGKLPPLPRSDSN--- 671

  Fly   777 LIGLLENMGKSPRTR----SLSDGGTQDDDEAEK 806
              |.:|.:. |.|.|    |:||...:.||..|:
plant   672 --GNVEPVA-SERERLLLSSISDLRARLDDLTEE 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	102/265 (38%)
		S_TKc	26..283	CDD:214567	102/264 (39%)
		CNH	869..1184	CDD:279162
AT4G24100	NP_001328320.1	STKc_OSR1_SPAK	47..310	CDD:270787	103/270 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910