DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and taok3a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_009299531.1	Gene:	taok3a / 798408	ZFINID:	ZDB-GENE-100921-50	Length:	903	Species:	Danio rerio

Alignment Length:	550	Identity:	169/550 - (30%)
Similarity:	251/550 - (45%)	Gaps:	132/550 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKL---EPSDDIQIIQQE 71
            ||:...|    :|::.:..:.:||.|::|.||.|:...|||:.|||.:..   :.::..|.|.:|
Zfish    17 ANLFFKD----DPEEVFCDLHEIGHGSFGAVYFARNSYSNEVVAIKKMSYNGKQTTEKWQDIIKE 77

  Fly    72 IIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQV-TGPLTEVQIAYMCRETLKGLE 135
            :..:...||||.|.|.|.||:.:..|:.||:| .||..|:.:| ..||.||:||.:....|.||.
Zfish    78 VKFLEQLRHPNTIEYKGCYLKDNTAWLVMEYC-LGSASDLLEVHKKPLQEVEIAAITHGALLGLA 141

  Fly   136 YLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGG 200
            ||||...:|||:|..||||||.|.||||||| ||.|.:..|   ||:||||||||||.....:|.
Zfish   142 YLHSHNMIHRDVKAGNILLTEPGQVKLADFG-SASIASPAN---SFVGTPYWMAPEVILAMDEGQ 202

  Fly   201 YNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALT 265
            |....|||:.|||.|||||.:||:|:::.|.||:.::::  ..|||.: ::||..|.:|:...|.
Zfish   203 YEGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQN--DSPTLQS-NEWSDAFRSFVDYCLL 264

  Fly   266 KNPKKRPTAERLLQHPFVQCEMSLRVAKELLQK------------YQSPNPQFYYYL------DG 312
            |.|:.||::..||:|.||:.:..|||..:|:|:            |:......|...      :.
Zfish   265 KIPQDRPSSAELLRHEFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILYQEKHNGPMGES 329

  Fly   313 DEESVAGVPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSS--SPETLPSDMSLLQYIDEE 375
            .||...|  .:...||.|.     ..||::.:  |:.||.::.||  |.:.:|.|
Zfish   330 QEEEEDG--DQAGCKMNSL-----GSNHSIPS--TSVSTGSQSSSVNSLQEVPDD---------- 375

  Fly   376 LKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHH 440
                                 |||.                                     .||
Zfish   376 ---------------------SCSE-------------------------------------LHH 382

  Fly   441 QH----QQHHQHHHHPNHLHQHQSHQ-----LPQQQQQ-----QSHQAAQQEHHHHHPMTSSI-S 490
            .:    :...||...|:  .||..||     :|.:..:     .|.:.||..::.:....::| |
Zfish   383 DYDSTLESSTQHKKVPD--AQHMDHQYIRDDIPHRDHRSDLRPSSSERAQAHNYKNRERFATIKS 445

  Fly   491 SGLVTANANNISSSASLASMPGLSAYLGMR 520
            :.|||...:.......|...  :|.|..||
Zfish   446 ASLVTRQIHEHEQENELREQ--MSGYKRMR 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	114/261 (44%)
		S_TKc	26..283	CDD:214567	114/260 (44%)
		CNH	869..1184	CDD:279162
taok3a	XP_009299531.1	PKc_like	7..319	CDD:304357	126/313 (40%)
taok3a	XP_009299531.1	S_TKc	29..282	CDD:214567	114/260 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910