Protein Alignment hppy and map4k6

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_005161478.1
• Gene: map4k6 / 692287
• ZFINID: ZDB-GENE-060512-339
• Length: 899
• Species: Danio rerio
• Alignment Length: 1221
• Identity: 454/1221 - (37%)
• Similarity: 609/1221 - (49%)
• Gaps: 336/1221 - (27%)

  Fly    12 MLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMR 76
            |.::.:|..:|.|:||||.:|||||||||:||:.|:::.:|||||:||:|.|||..||.||.||:
Zfish     1 MDTAGVSHTDPLDDYELIHRIGSGTYGDVFKARSIKTSVIAAIKVVKLDPGDDISSIQNEITMMK 65

  Fly    77 DCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMG 141
            ||.|.||:||:|||||.:||||||||||||||||||.|||||.|.||||:.||||:||.:||..|
Zfish    66 DCTHKNIVAYFGSYLRNNKLWICMEFCGGGSLQDIYHVTGPLKERQIAYVSRETLQGLHHLHQTG 130

  Fly   142 KMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCD 206
            |||||||||||||||.||||||||||:|:|.|::.||||||||||||||||||||:|||||||||
Zfish   131 KMHRDIKGANILLTERGDVKLADFGVAAEINASVAKRKSFIGTPYWMAPEVAAVEKKGGYNQLCD 195

  Fly   207 IWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKR 271
            |||.|||||||||||||||||||||||.|||||.|:||.|..|:|||..||:|||.||||||:||
Zfish   196 IWAVGITAIELAELQPPMFDLHPMRALMLMSKSSFQPPKLKEKNKWSTEFHSFIKMALTKNPRKR 260

  Fly   272 PTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLD-GDEESVAGVPQRIASKMTSRTNGV 335
            ||||::|||.||...::..:..|||....:|:.|....:| .|.|:.:.:|.:|
Zfish   261 PTAEKILQHAFVMQLLTRNLVIELLDTVNNPDLQQTQTMDESDLETCSVLPDKI----------- 314

  Fly   336 PAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSS 400
                |:|                 ..||...:|.:...:.:|.  .||:..:| ||      |
Zfish   315 ----HSL-----------------AKLPVQRTLSEQQFDHVKF--GLPMRKET-DP------C-- 347

  Fly   401 HNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQ 465
                                                                             
Zfish   348 ----------------------------------------------------------------- 347

  Fly   466 QQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMG 530
                                                         |.|.||...
Zfish   348 ---------------------------------------------PVLEAYDDW----------- 356

  Fly   531 FGMGLGMSNLRTTSIDADDDE---LVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYS 592
                        :||.||.|.   |...:.|:...:..:.         ..|....|.....:|.
Zfish   357 ------------SSISADKDSPSLLECVEEALMERSLTIK---------RVSSVEHSPNEEDKYG 400

  Fly   593 SNYRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGG 657
            :..|.|::.|::...|....           ||..|||.|                    .::|.
Zfish   401 TVKRMASSPQSTALCHQEKK-----------APTPSSIPS--------------------PIIGS 434

  Fly   658 NGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSA---GDGFSHSNSPTANSGAGATGSRDN 719
                    ||....|..||           |...::||   |...||.:..| ||....
Zfish   435 --------SSLKNPSPNTN-----------PSLLSESALLIGSTLSHMSLIT-NSCLFT------ 473

  Fly   720 DGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENM 784
               .||..||                |:|.|:.|                    :....||:...
Zfish   474 ---DSSFLSH----------------STSLGSLC--------------------LTPTEGLIPES 499

  Fly   785 GKSPRTRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSH-KRRHTPPRPISNGLPPTPKVHMG 848
            ..:|     ..|||:     .....||     .||.|:.|. :|:....:.:.|||||||:||||
Zfish   500 SVAP-----DPGGTR-----TYSTPPD-----SPVSPEWSTLRRKQDDSKAVVNGLPPTPQVHMG 549

  Fly   849 ACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVI 913
            |||||:||||||:.||..:|:.|:||||:|::|||||:|.||:||||:..:::|.|:|..||||:
Zfish   550 ACFSKVFNGCPLKTHCAVTWVLPKTRDQYLMLGAEEGVYTLNLNELHEDTMEKLLPQRCIWLYVM 614

  Fly   914 KDVLMSLSGKSCQLYRHDLVALH------SKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCT 972
            .:||||:||||.||..|.|.||.      .::....:::.:::..::..||:|::.|:||||.|.
Zfish   615 NNVLMSISGKSSQLTSHSLPALFEYRRNMQRRQGHLAINAHRLSTKINARKYAMSVKIPDTKGCR 679

  Fly   973 QCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFE 1037
            :|.|.|||||...:||.|.|:|:.|:.||:||.|||.||..   |:|:.         ...|:||
Zfish   680 RCSVVRNPYNDSVFLCAAVPTGLVLLMWYEPLQKFMQLKHI---ALSLP---------EFLPIFE 732

  Fly  1038 MIITPELEYPIVCTGVRKAMNGCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLLKVVRVHQV 1102
            :::....|.|.||.|||...|        ..:::...|.:.:..|.....:|..:.|:|.:|.|:
Zfish   733 LLVQETKELPQVCVGVRSYPN--------QKDTSGEMHFDIIHLDDTPQGLPDGETLEVKQVIQL 789

  Fly  1103 EKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGE 1167
            ::|.|||...|:::||.||....|.|  ..:|:|:|::.::|||.||||.|.|||::||||:..|
Zfish   790 DRDTILVALENIVKVVNLQACMSQQK--TPELDFEFSIHTLVCLQDSVLVFWKHGLKGKSLQTNE 852

  Fly  1168 VTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY 1218
            |||||.|.||.:::||:.:.:.|:|......|..|    :||||.|||:||
Zfish   853 VTQEITDRSRVFQVLGTSRDIILQSTPTDDPSAMS----NLYILTGHESSY 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	198/257 (77%)
		S_TKc	26..283	CDD:214567	198/256 (77%)
		CNH	869..1184	CDD:279162	129/320 (40%)
map4k6	XP_005161478.1	STKc_MAP4K3_like	14..272	CDD:270788	198/257 (77%)
		S_TKc	15..272	CDD:214567	198/256 (77%)
		CNH	565..879	CDD:295303	134/335 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm25498
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.780