DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and STK4

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_005260587.1	Gene:	STK4 / 6789	HGNCID:	11408	Length:	503	Species:	Homo sapiens

Alignment Length:	399	Identity:	158/399 - (39%)
Similarity:	237/399 - (59%)	Gaps:	45/399 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            |..|...:.|::.:::::|:|.|:||.||||...::.::.|||.:.:|  .|:|.|.:||.:|:.
Human    33 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIMQQ 95

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG-PLTEVQIAYMCRETLKGLEYLHSMG 141
            |..|:::.|||||.:...|||.||:||.||:.||.::.. .|||.:||.:.:.|||||||||.|.
Human    96 CDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMR 160

  Fly   142 KMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCD 206
            |:|||||..||||...|..|||||||:.|:|.|:.||.:.||||:||||||.   ::.|||.:.|
Human   161 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVAD 222

  Fly   207 IWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKR 271
            ||:.||||||:||.:||..|:|||||:|::..:  .|||....:.||..|.:|:|..|.|:|::|
Human   223 IWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSDNFTDFVKQCLVKSPEQR 285

  Fly   272 PTAERLLQHPFVQCEMSLRVAKEL--------LQKYQSPNPQFYYYLDGDEES------------ 316
            .||.:|||||||:....:.:.::|        |::.:|...:    :|.|:|.
Human   286 ATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQRE----VDQDDEENSEEDEMDSGTM 346

  Fly   317 VAGVPQ-----RIASKMTSRTNGVPAQNHTLKTGMTT---NSTWNERSSS----PETL-PSDMSL 368
            |..|..     |:||.||...|.:...:.||.:.:.|   |:...|...:    .||: |:..|.
Human   347 VRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSF 411

  Fly   369 LQYIDEELK 377
            |:|.:::.|
Human   412 LEYFEQKEK 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	127/258 (49%)
		S_TKc	26..283	CDD:214567	127/257 (49%)
		CNH	869..1184	CDD:279162
STK4	XP_005260587.1	STKc_MST1_2	42..297	CDD:132943	128/261 (49%)
		S_TKc	46..297	CDD:214567	127/257 (49%)
		Mst1_SARAH	449..496	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910