DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and STK3

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_016869245.1	Gene:	STK3 / 6788	HGNCID:	11406	Length:	580	Species:	Homo sapiens

Alignment Length:	426	Identity:	156/426 - (36%)
Similarity:	236/426 - (55%)	Gaps:	61/426 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            ||.|...:.|::.:::::|:|.|:||.|:||...:|.::.|||.:.:|  .|:|.|.:||.:|:.
Human    99 LSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIKEISIMQQ 161

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG-PLTEVQIAYMCRETLKGLEYLHSMG 141
            |..|.::.|||||.:...|||.||:||.||:.||.::.. .|.|.:||.:.:.|||||||||.|.
Human   162 CDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMR 226

  Fly   142 KMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCD 206
            |:|||||..||||...|..|||||||:.|:|.|:.||.:.||||:||||||.   ::.|||.:.|
Human   227 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVAD 288

  Fly   207 IWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKR 271
            ||:.|||:||:||.:||..|:|||||:|::..:  .|||....:.||..|.:|:|..|.|||::|
Human   289 IWSLGITSIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSDDFTDFVKKCLVKNPEQR 351

  Fly   272 PTAERLLQHPFVQCEMSLRVAKELL--------QKYQSPNPQFYYYLDGDEE------------- 315
            .||.:||||||::....:.:.::|:        ::::....:    |:.:||
Human   352 ATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRE----LEEEEENSDEDELDSHTMV 412

  Fly   316 --SVAGV-PQRIASKMTSRTNGVPAQNHTLKTG----MTTNS--------TWNERSSSPETLPSD 365
              ||..| ..|..|.|:.....:...|.|:...    |..||        |....::||:.  ..
Human   413 KTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQV--QR 475

  Fly   366 MSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSH 401
            .|.:.|.|::           |.|:.....|:.:.|
Human   476 PSFMDYFDKQ-----------DFKNKSHENCNQNMH 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	126/258 (49%)
		S_TKc	26..283	CDD:214567	126/257 (49%)
		CNH	869..1184	CDD:279162
STK3	XP_016869245.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910