DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and Myo3a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_680779.3	Gene:	Myo3a / 667663	MGIID:	2183924	Length:	1621	Species:	Mus musculus

Alignment Length:	371	Identity:	145/371 - (39%)
Similarity:	214/371 - (57%)	Gaps:	52/371 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDI-QIIQQEIIMMRDCR-HPNI 83
            :|.|.:|:|:.||.||||.|:|....:|.:.||:|:  |:|..|| :.|:.|..::|... |||:
Mouse    24 DPSDTWEIIETIGKGTYGKVFKVLNKKSGQKAAVKI--LDPIHDIDEEIEAEYNILRTLSDHPNV 86

  Fly    84 IAYYGSYLRR-----DKLWICMEFCGGGSLQDIYQVTG------PLTEVQIAYMCRETLKGLEYL 137
            :.:||.|.::     ||||:.:|.|.|||:.|:  |.|      .::|..|||:..|.|.||::|
Mouse    87 VRFYGIYFKKDKINGDKLWLVLELCNGGSVTDL--VKGFLKRGERMSEPVIAYILHEALMGLQHL 149

  Fly   138 HSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERK--GG 200
            ||...:|||:||.|||||..|.|||.|||||||:::|.::..:.:|||:||||||.|.|::  ..
Mouse   150 HSNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQLDTT 214

  Fly   201 YNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALT 265
            |:..||.|:.|||||||.:..||:.:||||||||.:.::  .||.|...:.||..|::||...||
Mouse   215 YDARCDTWSLGITAIELGDGDPPLAELHPMRALFKIPRN--PPPKLRQPELWSAEFNDFISKCLT 277

  Fly   266 KNPKKRPTAERLLQHPFV-QCEMSLRVAKE-LLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKM 328
            |:.:||||...||:|.|: |.|     .|: :|||      |...::|        :.|.:.|..
Mouse   278 KDYEKRPTVSDLLKHKFITQIE-----GKDVILQK------QLMEFID--------IHQCLGSTE 323

  Fly   329 TSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDE 374
            .:|...:    ||.|..:..:..    ||..:.  .|::.|..:||
Mouse   324 KARHERI----HTKKGNLNRSLI----SSLKDV--DDLATLDVLDE 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	122/272 (45%)
		S_TKc	26..283	CDD:214567	122/271 (45%)
		CNH	869..1184	CDD:279162
Myo3a	NP_680779.3	PKc_like	10..295	CDD:304357	124/276 (45%)
		S_TKc	29..295	CDD:214567	122/271 (45%)
		MYSc	345..1060	CDD:214580	4/17 (24%)
		MYSc_Myo3	360..1048	CDD:276830	145/371 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910