Protein Alignment hppy and MAP4K2

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_024304397.1
• Gene: MAP4K2 / 5871
• HGNCID: 6864
• Length: 860
• Species: Homo sapiens
• Alignment Length: 1229
• Identity: 435/1229 - (35%)
• Similarity: 571/1229 - (46%)
• Gaps: 394/1229 - (32%)

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            |..|:|.::|:|.:||:|::|:|||||||||:...::||||:|::||:|.|||..:||||.::|:
Human     3 LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGK 142
            |||||::||.|||||.|:||||||||||||||:||..||||.|.||||:|||.||||.:|||.||
Human    68 CRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGK 132

  Fly   143 MHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDI 207
            :||||||||:|||..|||||||||||.::||::.||:|||||||||||||||||||||||:|||:
Human   133 IHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDV 197

  Fly   208 WACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRP 272
            ||.|||||||.|||||:|.|||||||.|||||.|:||.|.:|.:|:..||:|:|.||||||||||
Human   198 WALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRP 262

  Fly   273 TAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPA 337
            |||:||||||...::...:..:||.|...|:              .|.|
Human   263 TAEKLLQHPFTTQQLPRALLTQLLDKASDPH--------------LGTP---------------- 297

  Fly   338 QNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHN 402
                                |||            |.||:.....|
Human   298 --------------------SPE------------DCELETYDMFP------------------- 311

  Fly   403 GGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQ-SHQLPQQ 466
                                              .|.|...||......|:.:..|| ....|::
Human   312 ----------------------------------DTIHSRGQHGPAERTPSEIQFHQVKFGAPRR 342

  Fly   467 QQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGF 531
            ::........:|..                                  ..||
Human   343 KETDPLNEPWEEEW----------------------------------TLLG------------- 360

  Fly   532 GMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYR 596
                             .:||                             |.|....::.:...|
Human   361 -----------------KEEL-----------------------------SGSLLQSVQEALEER 379

  Fly   597 SAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGG 661
            |.....||:...||          .|...:.|             |.|.......|.|.|..|.|
Human   380 SLTIRSASEFQVPH----------RGRLELGS-------------RPLQRVRLEWDVVTGQPGNG 421

  Fly   662 SSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSN 726
            .:                                                         ||..|
Human   422 RA---------------------------------------------------------GPCPS- 428

  Fly   727 SSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRTR 791
                ||.|                               |||.            :.||...|..
Human   429 ----YQEL-------------------------------DSPD------------DTMGTIKRAP 446

  Fly   792 SLSDGGTQDDDEAEKEAQPDLL-------NNTPPVPPK-RSHKRRHTPPRPISNGLPPTPKVHMG 848
            .|....|....|....:.|..|       |::|.:|.. .:.|:|..|.|...:|||||||||||
Human   447 FLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMG 511

  Fly   849 ACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVI 913
            |||||:|||||||:|...:||||.||||.|::|||||||.||::|||:..:::|...|.:|||.:
Human   512 ACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCV 576

  Fly   914 KDVLMSLSGKSCQLYRHDLVALHS----KQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQC 974
            .:||:||||||..::.|||..|..    :|.|..|:..|::.:|::||:|||:||:||||.|.||
Human   577 NNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQC 641

  Fly   975 CVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMI 1039
            .|.||||.|..:|..|.|:.:.|:|||:||.||:|||....|..|..|            :.|.:
Human   642 RVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAG------------MLEPL 694

  Fly  1040 ITPELEYPIVCTGVRKAMN-GCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLL--------K 1095
            :....|.|.||.|...... ||..|          ||...||    |.:.|  |:|        .
Human   695 VLDGKELPQVCVGAEGPEGPGCRVL----------FHVLPLE----AGLTP--DILIPPEGIPGS 743

  Fly  1096 VVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQG 1160
            ..:|.||::|.|||.:...:::|.:||.|.  ..:..:|.|||.::::|||.||||||..|||||
Human   744 AQQVIQVDRDTILVSFERCVRIVNMQGEPT--ATLAPELTFDFPIETVVCLQDSVLAFWSHGMQG 806

  Fly  1161 KSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGH-DLYILAGHEASY 1218
            :||...||||||.|.:|.:|:||:.:.:.|||  :.|   .:.|.| :||||.||:::|
Human   807 RSLDTNEVTQEITDETRIFRVLGAHRDIILES--IPT---DNPEAHSNLYILTGHQSTY 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	186/257 (72%)
		S_TKc	26..283	CDD:214567	186/256 (73%)
		CNH	869..1184	CDD:279162	137/327 (42%)
MAP4K2	XP_024304397.1	STKc_MAP4K3_like	16..272	CDD:270788	185/255 (73%)
		CNH	528..840	CDD:214481	142/343 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm40262
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.780