DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and Stk4

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_067395.1	Gene:	Stk4 / 58231	MGIID:	1929004	Length:	487	Species:	Mus musculus

Alignment Length:	419	Identity:	161/419 - (38%)
Similarity:	241/419 - (57%)	Gaps:	47/419 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            |..|...:.|::.:::::|:|.|:||.||||...::.::.|||.:.:|  .|:|.|.:||.:|:.
Mouse    17 LDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIKEISIMQQ 79

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG-PLTEVQIAYMCRETLKGLEYLHSMG 141
            |..|:::.|||||.:...|||.||:||.||:.||.::.. .|||.:||.:.:.|||||||||.|.
Mouse    80 CDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMR 144

  Fly   142 KMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCD 206
            |:|||||..||||...|..|||||||:.|:|.|:.||.:.||||:||||||.   ::.|||.:.|
Mouse   145 KIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVI---QEIGYNCVAD 206

  Fly   207 IWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKR 271
            ||:.||||||:||.:||..|:|||||:|::..:  .|||....:.||..|.:|:|..|.|:|::|
Mouse   207 IWSLGITAIEMAEGKPPYADIHPMRAIFMIPTN--PPPTFRKPELWSDNFMDFVKQCLVKSPEQR 269

  Fly   272 PTAERLLQHPFVQCEMSLRVAKELLQ-----KYQSPNPQFYYYLDGDEES-------------VA 318
            .||.:|||||||:....:.:.::|:.     |.:....|.......|||:             .|
Mouse   270 ATATQLLQHPFVKSAKGVSILRDLINEAMDVKLKRQEAQQREVDQDDEENSEEDEMDSGTMVRAA 334

  Fly   319 GVPQ---RIASKMTSRTNGVPAQNHTLKTGMTT---NSTWNERSSS----PETL-PSDMSLLQYI 372
            |...   |:||.|:...|.:.....||.:.:.|   |:...|...:    .||: |:..|.|:|.
Mouse   335 GDEMGTVRVASTMSGGANTMIEHGDTLPSQLGTMVINTEDEEEEGTMKRRDETMQPAKPSFLEYF 399

  Fly   373 DEELK----------LRATLPLNNDTKDP 391
            :::.|          :..:|..::|.|.|
Mouse   400 EQKEKENQINSFGKNVSGSLKNSSDWKIP 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	127/258 (49%)
		S_TKc	26..283	CDD:214567	127/257 (49%)
		CNH	869..1184	CDD:279162
Stk4	NP_067395.1	STKc_MST1_2	26..281	CDD:132943	128/261 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..334		4/28 (14%)
		Mst1_SARAH	433..480	CDD:314497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910