DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and PAK5

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_065074.1	Gene:	PAK5 / 57144	HGNCID:	15916	Length:	719	Species:	Homo sapiens

Alignment Length:	284	Identity:	107/284 - (37%)
Similarity:	162/284 - (57%)	Gaps:	6/284 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDCRHP 81
            :|..:|::......|||.|:.|.|..|....:.:..|:|.:.|......:::..|:::|||..|.
Human   440 VSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 504

  Fly    82 NIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRD 146
            |::..|.|||..|:||:.|||..||:|.||...| .:.|.|||.:|...|:.|.|||:.|.:|||
Human   505 NVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHT-RMNEEQIATVCLSVLRALSYLHNQGVIHRD 568

  Fly   147 IKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACG 211
            ||..:||||..|.:||:|||..||::..:.||||.:||||||||||.:   :..|....|||:.|
Human   569 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSLG 630

  Fly   212 ITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAER 276
            |..||:.:.:||.|:..|::|:..:..|  .||.:.:..|.|.....|:...|.:.|.:|.||:.
Human   631 IMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQE 693

  Fly   277 LLQHPFVQCEMSLRVAKELLQKYQ 300
            ||.|||::..........|:::|:
Human   694 LLGHPFLKLAGPPSCIVPLMRQYR 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	102/257 (40%)
		S_TKc	26..283	CDD:214567	102/256 (40%)
		CNH	869..1184	CDD:279162
PAK5	NP_065074.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		CRIB_PAK_like	9..55	CDD:238526
		Linker	25..448		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..373
		STKc_PAK5	426..717	CDD:132989	106/282 (38%)
		S_TKc	454..700	CDD:214567	102/251 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910