DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and map3k3

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_688694.2	Gene:	map3k3 / 560211	ZFINID:	ZDB-GENE-070910-1	Length:	620	Species:	Danio rerio

Alignment Length:	296	Identity:	100/296 - (33%)
Similarity:	149/296 - (50%)	Gaps:	33/296 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSSDISRRNPQDE------------YELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEP---- 61
            |.:..||..|||.            :...:.:|.|.:|.||....:.:....|.|.:..:|
Zfish   331 LENTQSRLRPQDRAVPHKSPTAPVTWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPE 395

  Fly    62 -SDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRD----KLWICMEFCGGGSLQDIYQVTGPLTEV 121
             |.::..::.||.::::..|..|:.|||..  ||    .|.|.||:..|||::|..:..|.|||.
Zfish   396 TSKEVSALECEIQLLKNLHHERIVQYYGCL--RDHNEKTLTIFMEYMPGGSVKDQLKAYGALTEN 458

  Fly   122 QIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQI-TATINKR--KSFIG 183
            ......|:.|:|:.||||...:||||||||||....|:|||.|||.|.:: |..::..  :|..|
Zfish   459 VTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTG 523

  Fly   184 TPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNN 248
            |||||:|||.:.|   ||.:..|:|:.|.|.:|:...:||..:...|.|:|   |...:|.....
Zfish   524 TPYWMSPEVISGE---GYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIF---KIATQPTNPQL 582

  Fly   249 KDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQ 284
            ....|....:|::....: .|.||:||.||:|||.|
Zfish   583 PSHISEHTRDFLRCIFVE-AKYRPSAEELLRHPFSQ 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	92/281 (33%)
		S_TKc	26..283	CDD:214567	92/268 (34%)
		CNH	869..1184	CDD:279162
map3k3	XP_688694.2	PB1_Mekk2_3	48..126	CDD:99726
		STKc_MEKK3_like	356..615	CDD:270795	91/267 (34%)
		S_TKc	356..615	CDD:214567	91/267 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910