Protein Alignment hppy and map4k3a

DIOPT Version :9

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: XP_009304401.1
• Gene: map4k3a / 558281
• ZFINID: ZDB-GENE-130329-1
• Length: 946
• Species: Danio rerio
• Alignment Length: 1236
• Identity: 501/1236 - (40%)
• Similarity: 642/1236 - (51%)
• Gaps: 324/1236 - (26%)

  Fly    14 SSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDC 78
            |.|:||||||:::||||:||||||||||||:.:.:.||||||||||||.:|..::|||||||:||
Zfish     4 SFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVTTGELAAIKVIKLEPGEDFAVVQQEIIMMKDC 68

  Fly    79 RHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKM 143
            :|.||:||:|||||||||||.||:||||||||||.|||||||.||||:.||||:||.|||:.|||
Zfish    69 KHSNIVAYFGSYLRRDKLWISMEYCGGGSLQDIYHVTGPLTESQIAYVTRETLQGLYYLHNKGKM 133

  Fly   144 HRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIW 208
            ||||||||||||:.|.|||||||||||||||:.||||||||||||||||||||||||||.|||||
Zfish   134 HRDIKGANILLTDNGYVKLADFGVSAQITATLAKRKSFIGTPYWMAPEVAAVERKGGYNHLCDIW 198

  Fly   209 ACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPT 273
            |.||||||||||||||||||||||||||:||.|:||.|.:|.||:..||||:|.||||||||||.
Zfish   199 AVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKVKWTNNFHNFVKLALTKNPKKRPP 263

  Fly   274 AERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDE---ESVAGVPQRIASKMTSRTNGV 335
            |::|||||.|...:|..:|.|||.|..:|:...|..||.|:   |....||.||.|  ||||:
Zfish   264 ADKLLQHPLVSQPLSRILAIELLDKANNPDHSSYTDLDDDDPEPEPPVSVPHRIRS--TSRTS-- 324

  Fly   336 PAQNHTLK----------TGMTTNSTWNERSSSPETLPSDMSLLQYID--EEL--KLRATLPLNN 386
             .:..||.          ..:||     |.....|.|.:|    .::|  ||:  ..|:.|.|..
Zfish   325 -REGKTLSEINFGQVKFDPPLTT-----ETKPHHEQLDTD----DFLDCAEEIYYTARSNLDLQM 379

  Fly   387 DTKDPLGAECSCSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHH 451
            |.:.        .|..|...||               |.|...|
Zfish   380 DYEQ--------GSPKGSILGG---------------NKSLLKS--------------------- 400

  Fly   452 PNHLHQHQSHQLPQQQQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAY 516
                       :.::.||:.|:|
Zfish   401 -----------VEEELQQRGHEA------------------------------------------ 412

  Fly   517 LGMRSHVVGHMGMGFGMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGC 581
                     |:                   .||||                      |...|...
Zfish   413 ---------HL-------------------EDDDE----------------------GEDDGDDH 427

  Fly   582 SASAAHYLRYSSNYRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLL 646
            .....|              ..|....|.|.
Zfish   428 DDELQH--------------TKSSTMRPKVP---------------------------------- 444

  Fly   647 DNSSGDAVVGGNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGA 711
                                                  ..||.....|.|...|.|..|..|:..
Zfish   445 --------------------------------------PPLPPKPKPSPGPHQSPSADPDRNNQG 471

  Fly   712 GATGSRDNDGPSSSNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQ 776
            ......:.:.|:.|::|    ...|......||...|:..|..::.|:...|.:......|..||
Zfish   472 TIKRCPEPESPARSSTS----VPPRPPPPRLPAYKLSSLGNETHQEEHGLWGAQGDAGICSQFDQ 532

  Fly   777 LIGLLENMGKSPRTRSLSDGGTQDDDE-------AEKEAQPDLLNNTPPVPPKRSHKRRHTPPRP 834
            .:.:           |..|....|::|       :|..|..:..:..||..|....|:..  |:|
Zfish   533 RLQV-----------SFDDEENHDEEENSNGISPSEHSASTERQSTMPPAVPVPKDKKDF--PKP 584

  Fly   835 ISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAI 899
            |||||||||||||||||||:||||||::||..|||:|:||||:|:.|||||||.||:||||:.::
Zfish   585 ISNGLPPTPKVHMGACFSKVFNGCPLKIHCATSWINPDTRDQYLIFGAEEGIYTLNLNELHETSM 649

  Fly   900 DQLFPRRTTWLYVIKDVLMSLSGKSCQLYRHDLVAL--HSKQTVRF--SLHMNKIPERLVPRKFA 960
            :||.|||.|||||:.:.|:|:|||:|.||.|.|..|  |::|..:.  |:..:|:|::::||||:
Zfish   650 EQLVPRRCTWLYVLSNSLLSISGKACHLYSHSLSGLFEHARQMQKLPVSIPTHKLPDKMIPRKFS 714

  Fly   961 LTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGH 1025
            ::.|:|:||.|.:|||.||||.|:||||||..|.|.|.:|.:.:.||||:|..::|.
Zfish   715 VSNKIPETKGCQKCCVVRNPYTGHKYLCGAFQSSIALFEWVETMQKFMLVKSIDFPL-------- 771

  Fly  1026 GCVQNGHTPVFEMIITPELEYPIVCTGVRKA--MNGCLKLELINMNSAS-WFHSEDLEYDAMATM 1087
            .|    ...||||::.||.:||::|..|.|.  :|..::.|.:|.||.| ||.|:
Zfish   772 PC----PLEVFEMLVVPEHQYPLICIAVSKGTELNQVVRFETLNPNSTSNWFDSD---------- 822

  Fly  1088 VPRRDLLKVVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLA 1152
            .|:.   .|:.|.|:|:|.||||....|::|.|||..|..:|:.::|.|:|.::|||||.|||||
Zfish   823 TPQS---CVIHVTQLERDTILVCLDRCIKIVNLQGRLKSSRKLSAELTFNFQIESIVCLQDSVLA 884

  Fly  1153 FHKHGMQGKSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEAS 1217
            |.:|||||:|.::.|:||||.|.||.:||||||:||.|||:.....:..|    :||||||||.|
Zfish   885 FWRHGMQGRSFKSNEITQEISDNSRIFRLLGSDRVVVLESRPTDNPTAHS----NLYILAGHENS 945

  Fly  1218 Y 1218
            |
Zfish   946 Y 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	205/257 (80%)
		S_TKc	26..283	CDD:214567	205/256 (80%)
		CNH	869..1184	CDD:279162	148/321 (46%)
map4k3a	XP_009304401.1	STKc_MAP4K3_like	15..273	CDD:270788	205/257 (80%)
		S_TKc	16..273	CDD:214567	205/256 (80%)
		CNH	614..926	CDD:214481	159/336 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I542
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I387
OMA	1	1.010	-	-		QHG45812
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm25498
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4905
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870