DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and taok2a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_009297645.1	Gene:	taok2a / 556172	ZFINID:	ZDB-GENE-030131-9416	Length:	1141	Species:	Danio rerio

Alignment Length:	539	Identity:	164/539 - (30%)
Similarity:	257/539 - (47%)	Gaps:	96/539 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SHHNANMLSSDIS----RRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKL---EPSD 63
            |.....:..|::|    |.:|:..:..:::||.|::|.||.|..::|||:.|||.:..   :.::
Zfish     4 SVRTGTLKDSEVSELFYRDDPEKLFTDLREIGHGSFGAVYFAHDVRSNEVVAIKKMSFSGKQSNE 68

  Fly    64 DIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQV-TGPLTEVQIAYMC 127
            ..|.|.:|:..::..||||.|.|.|.|||....|:.||:| .||..|:.:| ..||.|::||.:.
Zfish    69 KWQDIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEMEIAAIT 132

  Fly   128 RETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEV 192
            ...|:||.||||...:|||:|..||||||.|.|||.||| ||.|.:..|   ||:||||||||||
Zfish   133 HGALQGLAYLHSHNMIHRDVKAGNILLTEPGQVKLGDFG-SASIVSPAN---SFVGTPYWMAPEV 193

  Fly   193 AAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFH 257
            .....:|.|:...|:|:.|||:|||||.:||:|:::.|.||:.::::  :.|.|.: :.||..|.
Zfish   194 ILAMDEGQYDGKVDVWSLGITSIELAERKPPLFNMNAMSALYHIAQN--ESPVLAS-NHWSDYFR 255

  Fly   258 NFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQS-----PNPQFYYYLDGDEESV 317
            ||:.:.|.|.|:.|||::.||.|.|:..|....|..:|:.:.:.     .|.|:
Zfish   256 NFVDSCLQKIPQDRPTSDVLLNHHFLCRERPHSVVMDLITRTKDAVRELDNLQY----------- 309

  Fly   318 AGVPQRIASKMTSRTNGVPAQ----------NHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYI 372
                :::...:...|:..|.|          .:.|:|| |.||     ..|.:::|| ||
Zfish   310 ----RKMKKILFQETHNGPVQEGGEEEEEGEQYLLQTG-TVNS-----MESSQSVPS-MS----- 358

  Fly   373 DEELKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGT 437
                               :.|....||.|..|.|......:.:...|.....|:||
Zfish   359 -------------------ISASSQSSSVNSLADGSDDSAEMAMMQEGEQTVTSNSS-------- 396

  Fly   438 THHQHQQHHQHHHHPNHLHQHQSHQLPQQQQQQSHQAAQQEHHHHHPMTSSI-SSGLVTANANNI 501
            ..|:.......:..|        :|...:.||.:..||::..|.:....::| ::.:||......
Zfish   397 IIHRPSARDNIYDDP--------YQPEMESQQPASSAARRRIHRNRDHFATIRTASVVTRQIQEH 453

  Fly   502 SSSASLASMPGLSAYLGMR 520
            ...::|...  :|.|..||
Zfish   454 EQGSALREQ--MSGYKRMR 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	113/261 (43%)
		S_TKc	26..283	CDD:214567	113/260 (43%)
		CNH	869..1184	CDD:279162
taok2a	XP_009297645.1	PKc_like	6..318	CDD:304357	123/334 (37%)
taok2a	XP_009297645.1	S_TKc	28..281	CDD:214567	113/260 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910