DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and stk24a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001103921.1	Gene:	stk24a / 555297	ZFINID:	ZDB-GENE-070424-52	Length:	415	Species:	Danio rerio

Alignment Length:	395	Identity:	148/395 - (37%)
Similarity:	214/395 - (54%)	Gaps:	76/395 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPS-DDIQIIQQEIIMMRDCRHPNII 84
            :|:..:..:::||.|::|:|:|....::.::.|||:|.||.: |:::.|||||.::..|....|.
Zfish    12 DPEKLFTKLERIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEVEDIQQEITVLSQCDSLFIT 76

  Fly    85 AYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKG 149
            .|:||||:..||||.||:.||||..|:.. .|.|.|..||.:.||.||||:||||..|:|||||.
Zfish    77 KYFGSYLKDTKLWIIMEYLGGGSALDLLG-PGALDETHIATILREILKGLDYLHSEKKIHRDIKA 140

  Fly   150 ANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITA 214
            ||:||:|.||||||||||:.|:|.|..||.:|:|||:||||||.   ::..|:...|||:.||||
Zfish   141 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---KQSEYDSKADIWSLGITA 202

  Fly   215 IELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQ 279
            ||||:.:||..|||||:.|||:.|.  .||||  :..::.....|:...|.|:|..||||:.||:
Zfish   203 IELAKGEPPHSDLHPMKVLFLIPKE--NPPTL--EGNYNKALKEFVDACLNKDPNFRPTAKELLK 263

  Fly   280 HPFVQCEMSLRVAK------ELLQKY----------QSPNPQFYYYLDGDEESVAG--------- 319
            |..:     :|.:|      :|:.||          :|.:..     |.|||..:|
Zfish   264 HKLI-----VRYSKKTSYLMDLIDKYKKWKLKQAREESSSDS-----DSDEEEASGESVNDDWIF 318

  Fly   320 ----------VPQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSD--MSLLQYI 372
                      .|.|:...:.::...||                    ..|:..||.  .|::..:
Zfish   319 NTITESKPIQEPNRVLKPVENKPKKVP--------------------DRPKRSPSQSMSSIMSPL 363

  Fly   373 DEELK 377
            ..|||
Zfish   364 FAELK 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	125/258 (48%)
		S_TKc	26..283	CDD:214567	125/257 (49%)
		CNH	869..1184	CDD:279162
stk24a	NP_001103921.1	STKc_MST3_like	15..288	CDD:270786	130/285 (46%)
stk24a	NP_001103921.1	S_TKc	17..267	CDD:214567	125/257 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910