DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and taok1b

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_009293944.1	Gene:	taok1b / 554108	ZFINID:	ZDB-GENE-141024-1	Length:	1001	Species:	Danio rerio

Alignment Length:	406	Identity:	144/406 - (35%)
Similarity:	215/406 - (52%)	Gaps:	71/406 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKL---EPSDDIQIIQQEIIMMRDCRH 80
            :.:|:..:..:::||.|::|.||.|:.::::|:.|||.:..   :.::..|.|.:|:..::..:|
Zfish    21 KEDPEKLFSDLREIGHGSFGAVYFARDVRTSEVVAIKKMLYSGKQSNEKWQDIIKEVKFLQRIQH 85

  Fly    81 PNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQV-TGPLTEVQIAYMCRETLKGLEYLHSMGKMH 144
            ||.|.|.|.|||....|:.||:| .||..|:.:| ..||.|::||.:....|:||.||||...:|
Zfish    86 PNSIEYKGCYLREHTAWLVMEYC-LGSASDLLEVHKKPLQEIEIAAITHGALQGLAYLHSHNMIH 149

  Fly   145 RDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWA 209
            ||||..||||||.|.||||||| ||.|.:..|   ||:||||||||||.....:|.|:...|||:
Zfish   150 RDIKAGNILLTEPGQVKLADFG-SASIASPAN---SFVGTPYWMAPEVILAMDEGQYDGKVDIWS 210

  Fly   210 CGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTA 274
            .|||.|||||.:||:|:::.|.||:.::::  :.|||.:.: |:..|.|||.:.|.|.||.||.:
Zfish   211 LGITCIELAERKPPLFNMNAMSALYHIAQN--ESPTLQSSE-WTDYFRNFIDSCLQKIPKDRPHS 272

  Fly   275 ERLLQHPFVQCE----------------------MSLRVAKELL--QKYQSPNPQFYYYLDGDEE 315
            :.||||.||..|                      :..|..|:||  :.:..|..:.:   :|:||
Zfish   273 KDLLQHAFVLRERPHSVLVDLILRTKDAVRELDNLQYRKMKKLLFQEAHNGPTTETH---EGEEE 334

  Fly   316 SVAGV-----------PQRI------ASKMTSRTNGVP-----------AQNHTLKTGMTTNSTW 352
            :..||           .|.|      ||..:|..|.:|           .::||:.:..:.....
Zfish   335 AEHGVGRTGTVSSVGSNQSIPSMSISASSQSSSVNSLPDAADDKSDLDLEKDHTVMSNSSVIHLK 399

  Fly   353 NERS----SSPETLPS 364
            .|..    ..|||.||
Zfish   400 PEEEEVYREDPETRPS 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	115/261 (44%)
		S_TKc	26..283	CDD:214567	115/260 (44%)
		CNH	869..1184	CDD:279162
taok1b	XP_009293944.1	PKc_like	6..318	CDD:304357	123/304 (40%)
taok1b	XP_009293944.1	S_TKc	28..281	CDD:214567	115/260 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910