DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and MYO3A

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_059129.3	Gene:	MYO3A / 53904	HGNCID:	7601	Length:	1616	Species:	Homo sapiens

Alignment Length:	374	Identity:	144/374 - (38%)
Similarity:	209/374 - (55%)	Gaps:	58/374 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEI-----IMMRDCRH 80
            :|.|.:|:.:.||.||||.|:|....::.:.||:|::     |.|..|.:||     |:.....|
Human    16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKIL-----DPIHDIDEEIEAEYNILKALSDH 75

  Fly    81 PNIIAYYGSYLRR-----DKLWICMEFCGGGSLQDIYQVTG------PLTEVQIAYMCRETLKGL 134
            ||::.:||.|.::     ||||:.:|.|.|||:.|:  |.|      .::|..|||:..|.|.||
Human    76 PNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDL--VKGFLKRGERMSEPLIAYILHEALMGL 138

  Fly   135 EYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERK- 198
            ::||:...:|||:||.|||||..|.|||.|||||||:|:|.::|.:.:|||:||||||.|.|::
Human   139 QHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIACEQQL 203

  Fly   199 -GGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKT 262
             ..|:..||.|:.|||||||.:..||:.|||||||||.:.::  .||.|...:.||..|::||..
Human   204 DTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRN--PPPKLRQPELWSAEFNDFISK 266

  Fly   263 ALTKNPKKRPTAERLLQHPFV-QCEMSLRVAKE-LLQKYQSPNPQFYYYLDGDEESVAGVPQRIA 325
            .|||:.:||||...||||.|: |.|     .|: :|||      |...::        |:.|.:.
Human   267 CLTKDYEKRPTVSELLQHKFITQIE-----GKDVMLQK------QLTEFI--------GIHQCMG 312

  Fly   326 SKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDE 374
            ....:|...:    ||.|      ..:|....|......|::.|:.:||
Human   313 GTEKARRERI----HTKK------GNFNRPLISNLKDVDDLATLEILDE 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	122/275 (44%)
		S_TKc	26..283	CDD:214567	122/274 (45%)
		CNH	869..1184	CDD:279162
MYO3A	NP_059129.3	STKc_myosinIIIA_N	2..287	CDD:132969	124/279 (44%)
		S_TKc	21..287	CDD:214567	122/274 (45%)
		MYSc	337..1053	CDD:214580	4/15 (27%)
		MYSc_Myo3	352..1041	CDD:276830	144/374 (39%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	934..956
		Interaction with MORN4. /evidence=ECO:0000269\|PubMed:25822849	1401..1479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1567
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1581..1616
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910