DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hppy and Stk39

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_058562.1	Gene:	Stk39 / 53416	MGIID:	1858416	Length:	556	Species:	Mus musculus

Alignment Length:	377	Identity:	134/377 - (35%)
Similarity:	188/377 - (49%)	Gaps:	64/377 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEP-SDDIQIIQQEIIMMRDCRHPNIIAY 86
            :|.|||.:.||||....|..|......|..|||.|.||. ...:..:.:||..|..|.|||::.|
Mouse    72 RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTY 136

  Fly    87 YGSYLRRDKLWICMEFCGGGSLQDIYQV--------TGPLTEVQIAYMCRETLKGLEYLHSMGKM 143
            |.|::.:|:||:.|:...|||:.||.:.        .|.|.|..||.:.:|.|:||:|||..|::
Mouse   137 YTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQI 201

  Fly   144 HRDIKGANILLTEYGDVKLADFGVSAQIT----ATINK-RKSFIGTPYWMAPEVAAVERKGGYNQ 203
            |||:|..||||.|.|.|::|||||||.:.    .|.|| ||:|:|||.||||||  :|:..||:.
Mouse   202 HRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEV--MEQVRGYDF 264

  Fly   204 LCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTL----NNKD---KWSPTFHNFIK 261
            ..|:|:.||||||||....|.....||:.|.|..::  .||||    .:|:   |:..:|...:.
Mouse   265 KADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQN--DPPTLETGVEDKEMMKKYGKSFRKLLS 327

  Fly   262 TALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQSPNP-----------------QFYYY 309
            ..|.|:|.|||||..||:..|.|   ..:..:.|::|..:..|                 ..:..
Mouse   328 LCLQKDPSKRPTAAELLKCKFFQ---KAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKT 389

  Fly   310 LDGD------------EESVAGVPQRIA-------SKMTSRTNGVPAQNHTL 342
            .|||            ||..|...|..:       |:::....|:|.|..:|
Mouse   390 EDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENSEISVNAGGIPEQIQSL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	116/278 (42%)
		S_TKc	26..283	CDD:214567	116/277 (42%)
		CNH	869..1184	CDD:279162
Stk39	NP_058562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		STKc_OSR1_SPAK	73..349	CDD:270787	117/279 (42%)
		S_TKc	75..349	CDD:214567	116/277 (42%)
		Interaction with RELT. /evidence=ECO:0000269\|PubMed:16530727	322..547		28/123 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	372..378		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..434		8/60 (13%)
		Caspase cleavage related site	399..403		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910