DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hppy and STK26

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_057626.2	Gene:	STK26 / 51765	HGNCID:	18174	Length:	416	Species:	Homo sapiens

Alignment Length:	315	Identity:	142/315 - (45%)
Similarity:	204/315 - (64%)	Gaps:	17/315 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPS-DDIQIIQQEIIMMRDCRHPNII 84
            :|::.:..:::||.|::|:|:|....::.::.|||:|.||.: |:|:.|||||.::..|....:.
Human    19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVT 83

  Fly    85 AYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKG 149
            .||||||:..||||.||:.||||..|:.: .||..|.|||.|.:|.||||:||||..|:|||||.
Human    84 KYYGSYLKGSKLWIIMEYLGGGSALDLLR-AGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147

  Fly   150 ANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITA 214
            ||:||:|.||||||||||:.|:|.|..||.:|:|||:||||||.   ::..|:...|||:.||||
Human   148 ANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI---QQSAYDSKADIWSLGITA 209

  Fly   215 IELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQ 279
            ||||:.:||..|:||||.|||:.|:  .||||  ...::.:|..||...|.|:|..||||:.||:
Human   210 IELAKGEPPNSDMHPMRVLFLIPKN--NPPTL--VGDFTKSFKEFIDACLNKDPSFRPTAKELLK 270

  Fly   280 HPF-VQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTN 333
            |.| |:.........||:.:::....:.:    .|:||.:   :...|:.|||.|
Human   271 HKFIVKNSKKTSYLTELIDRFKRWKAEGH----SDDESDS---EGSDSESTSREN 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	130/259 (50%)
		S_TKc	26..283	CDD:214567	130/258 (50%)
		CNH	869..1184	CDD:279162
STK26	NP_057626.2	STKc_MST4	19..295	CDD:132971	134/283 (47%)
STK26	NP_057626.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..340		8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910