DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and PAK3

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001121640.1	Gene:	PAK3 / 5063	HGNCID:	8592	Length:	580	Species:	Homo sapiens

Alignment Length:	283	Identity:	125/283 - (44%)
Similarity:	175/283 - (61%)	Gaps:	12/283 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            |.|.:|..:|:.:|...:|||.|..|.||.|..|.:.:..|||.:.|:.....::|..||::||:
Human   291 LRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRE 355

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGK 142
            .::|||:.|..|||..|:||:.||:..||||.|:...| .:.|.|||.:|||.|:.|::|||...
Human   356 NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAAVCRECLQALDFLHSNQV 419

  Fly   143 MHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDI 207
            :|||||..||||...|.|||.|||..||||...:||.:.:||||||||||  |.|| .|....||
Human   420 IHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-AYGPKVDI 481

  Fly   208 WACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRP 272
            |:.||.|||:.|.:||..:.:|:|||:|::.:|  .|.|.|.::.|..|.:|:...|..:..:|.
Human   482 WSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPERLSAVFRDFLNRCLEMDVDRRG 544

  Fly   273 TAERLLQHPFVQCEMSLRVAKEL 295
            :|:.||||||      |::||.|
Human   545 SAKELLQHPF------LKLAKPL 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	116/257 (45%)
		S_TKc	26..283	CDD:214567	116/256 (45%)
		CNH	869..1184	CDD:279162
PAK3	NP_001121640.1	PBD	69..162	CDD:307091
PAK3	NP_001121640.1	STKc_PAK3	284..580	CDD:132987	125/283 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910