DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and PAK2

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_002568.2	Gene:	PAK2 / 5062	HGNCID:	8591	Length:	524	Species:	Homo sapiens

Alignment Length:	283	Identity:	122/283 - (43%)
Similarity:	176/283 - (62%)	Gaps:	12/283 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77
            |.:.:|..:|:.:|...:|||.|..|.|:.|..:...:..|||.|.|:.....::|..||::|::
Human   236 LRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKE 300

  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGK 142
            .::|||:.:..|||..|:|::.||:..||||.|:...| .:.|.|||.:|||.|:.||:||:...
Human   301 LKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAAVCRECLQALEFLHANQV 364

  Fly   143 MHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDI 207
            :|||||..|:||...|.|||.|||..||||...:||.:.:||||||||||  |.|| .|....||
Human   365 IHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-AYGPKVDI 426

  Fly   208 WACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRP 272
            |:.||.|||:.|.:||..:.:|:|||:|::.:|  .|.|.|.:|.||.|.:|:...|..:.:||.
Human   427 WSLGIMAIEMVEGEPPYLNENPLRALYLIATNG--TPELQNPEKLSPIFRDFLNRCLEMDVEKRG 489

  Fly   273 TAERLLQHPFVQCEMSLRVAKEL 295
            :|:.||||||      |::||.|
Human   490 SAKELLQHPF------LKLAKPL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	114/257 (44%)
		S_TKc	26..283	CDD:214567	114/256 (45%)
		CNH	869..1184	CDD:279162
PAK2	NP_002568.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		Autoregulatory region. /evidence=ECO:0000250	69..137
		GTPase-binding. /evidence=ECO:0000250	69..112
		PBD	73..130	CDD:307091
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..188
		STKc_PAK2	229..524	CDD:132986	122/283 (43%)
		Nuclear localization signal	245..251		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910