DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hppy and Map4k5

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_001178945.1	Gene:	Map4k5 / 503027	RGDID:	1562028	Length:	846	Species:	Rattus norvegicus

Alignment Length:	1217	Identity:	485/1217 - (39%)
Similarity:	622/1217 - (51%)	Gaps:	390/1217 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDC 78
            ::||.|||||.:|||:|::|||||||||||:.:.:.||||:|:|||||.||..:|||||.|:::|
  Rat     8 AADILRRNPQHDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKEC 72

  Fly    79 RHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKM 143
            :|.||:||:||||.|:|||||||:||||||||||.|||||:|:||||:|||||:||.|||:.|||
  Rat    73 KHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKM 137

  Fly   144 HRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIW 208
            ||||||||||||::||||||||||:|:|||||.||||||||||||||||||||:.||||||||||
  Rat   138 HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIW 202

  Fly   209 ACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPT 273
            |.|||||||.|||||||||||||||||||||.|:||.|.:|.|||.|||||:|.|||||||||||
  Rat   203 AVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPT 267

  Fly   274 AERLLQHPFV-QCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPA 337
            |||||.|.|| |..:|..:|.|||.|..:|: ...:|.:||::...  |..|.
  Rat   268 AERLLTHTFVGQSGLSRALAVELLDKVNNPD-NHAHYSEGDDDDFE--PHAII------------ 317

  Fly   338 QNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHN 402
             .||::   :||     |:|..|...|:::.     ::|:....|....:.:|.:|..
  Rat   318 -RHTIR---STN-----RNSRAERTASEINF-----DKLQFEPPLRKETEARDEMGLS------- 361

  Fly   403 GGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQQ 467
                                                           ..||.:
  Rat   362 -----------------------------------------------SEPNFI------------ 367

  Fly   468 QQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGFG 532
                        .|.:|.....::|
  Rat   368 ------------LHWNPFVDGANTG---------------------------------------- 380

  Fly   533 MGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRS 597
                    |:||                  ..|:|
  Rat   381 --------RSTS------------------KRAIP------------------------------ 389

  Fly   598 AAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGGS 662
                 ......|.:||                          |....|.|......|
  Rat   390 -----PPLPPKPRINS--------------------------YPEESLPDEEKSSTV-------- 415

  Fly   663 SNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSNS 727
                                  ...|...|::.
  Rat   416 ----------------------KRCPDPETRAP-------------------------------- 426

  Fly   728 SHLYQNLLRSSSGE-TP-AGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRT 790
                |.|.|.||.. .| |.:||.||.         ||:          .:||.  ||
  Rat   427 ----QVLRRQSSPSCVPIAETSSVGNG---------NGI----------SKLIS--EN------- 459

  Fly   791 RSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIF 855
               ::|..|                 .|..|::..||..  |:|..|||||||||.|||||||:|
  Rat   460 ---TEGSAQ-----------------APQLPRKKDKRDF--PKPTINGLPPTPKVLMGACFSKVF 502

  Fly   856 NGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMSL 920
            :||||:::|..|||||:|:||:::.|.|:|||.||:||||:|.::|||||:.||||||.:.||||
  Rat   503 DGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMSL 567

  Fly   921 S-GKSCQLYRHDLVALH---SKQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPY 981
            | ||:.|||.|:|:||.   .|..:...:..::.|:|::|||||||||:||||.|.:||:.||||
  Rat   568 SEGKTFQLYSHNLIALFEQAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRNPY 632

  Fly   982 NGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTP--VFEMIITPEL 1044
            .|:||||||..|||.|:|||:|:.||||:|..::|..|              |  ||||::.||.
  Rat   633 TGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPS--------------PLNVFEMLVIPEQ 683

  Fly  1045 EYPIVCTGVRKA--MNGCLKLELINMNSA-SWFHSEDLEYDAMATMVPRRDLLKVVRVHQVEKDA 1106
            |||:||..:.|.  .|..::.|.||:||| |||    .|..|.:..      |..:.|.|:|:|.
  Rat   684 EYPMVCVAISKGTESNQVVQFETINLNSASSWF----TEIGAGSQQ------LDSIHVTQLERDT 738

  Fly  1107 ILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSLRNGEVTQE 1171
            :|||....:::|.|||..|..||:.|:|:|||.::|:|||.||||||.||||||||.::.|||||
  Rat   739 VLVCLDKFVKIVNLQGKLKPSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSDEVTQE 803

  Fly  1172 IKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY 1218
            |.|.:|.:||||||:||.|||:.....:..|    :||||||||.||
  Rat   804 ISDETRVFRLLGSDRVVVLESRPTENPTAHS----NLYILAGHENSY 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	202/257 (79%)
		S_TKc	26..283	CDD:214567	202/256 (79%)
		CNH	869..1184	CDD:279162	162/323 (50%)
Map4k5	NP_001178945.1	STKc_MAP4K5	10..277	CDD:270813	209/266 (79%)
		S_TKc	20..277	CDD:214567	202/256 (79%)
		CNH	511..826	CDD:214481	173/338 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	448	1.000	Domainoid score	I499
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	899	1.000	Inparanoid score	I363
OMA	1	1.010	-	-		QHG45812
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm44388
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840