DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and Myo3a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_574090.6	Gene:	Myo3a / 498806	RGDID:	1560083	Length:	268	Species:	Rattus norvegicus

Alignment Length:	235	Identity:	106/235 - (45%)
Similarity:	154/235 - (65%)	Gaps:	19/235 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDI-QIIQQEIIMMRDCR-HPNI 83
            :|.|.:|:.:.||.||||.|:|....::.:.||:|:  |:|..|| :.|:.|..::|... |||:
  Rat    16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKI--LDPIHDIDEEIEAEYNILRTLSDHPNV 78

  Fly    84 IAYYGSYLRR-----DKLWICMEFCGGGSLQDIYQVTG------PLTEVQIAYMCRETLKGLEYL 137
            :.:||.|.::     ||||:.:|.|.|||:.|:  |.|      .::|..|||:..|.|.||::|
  Rat    79 VRFYGIYFKKDKINGDKLWLVLELCNGGSVTDL--VKGFLKRGERMSEPIIAYILHEALMGLQHL 141

  Fly   138 HSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERK--GG 200
            ||...:|||:||.|||||..|.|||.|||||||:::|.::..:.:|||:||||||.|.|::  ..
  Rat   142 HSNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLSSTRHRLNTSVGTPFWMAPEVIACEQQLDTT 206

  Fly   201 YNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSG 240
            |:..||.|:.|||||||.:..||:.:||||||||.:.:||
  Rat   207 YDARCDTWSLGITAIELGDGDPPLAELHPMRALFKIPRSG 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	104/231 (45%)
		S_TKc	26..283	CDD:214567	104/230 (45%)
		CNH	869..1184	CDD:279162
Myo3a	XP_574090.6	PKc_like	2..258	CDD:419665	106/235 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910