DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and stk25a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	XP_005165982.1	Gene:	stk25a / 449653	ZFINID:	ZDB-GENE-041010-92	Length:	424	Species:	Danio rerio

Alignment Length:	395	Identity:	161/395 - (40%)
Similarity:	230/395 - (58%)	Gaps:	45/395 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAAHSHHNANMLSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPS-DD 64
            ||...:..|.|      ||.||::.:..:::||.|::|:|||....::.|:.|||:|.||.: |:
Zfish     1 MAHLQNIRNQN------SRLNPEEYFTKLERIGKGSFGEVYKGINNRTKEVVAIKIIDLEEAEDE 59

  Fly    65 IQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRE 129
            |:.|||||.::..|..|.:..||||||...||||.||:.||||..|:.: .|.|.||.||.:.||
Zfish    60 IEDIQQEITVLSQCDSPYVTKYYGSYLTGSKLWIIMEYLGGGSALDLLR-PGTLEEVYIATILRE 123

  Fly   130 TLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAA 194
            .||||:||||..|:|||||.||:||:|:|:||||||||:.|:|.|..||.:|:|||:||||||.
Zfish   124 ILKGLDYLHSERKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVI- 187

  Fly   195 VERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNF 259
              ::..|:...|||:.||||||||:.:||..:|||||.|||:.|:  .||||  :..:|..|.:|
Zfish   188 --KQSAYDFKADIWSLGITAIELAKGEPPNAELHPMRVLFLIPKN--NPPTL--EGSYSKAFKDF 246

  Fly   260 IKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAK------ELLQKYQSPNPQFYYYLDGDEESVA 318
            ::..|.|.|:.||||:.||:|.|:     .|..|      ||:.:|:.      :..:|..|..:
Zfish   247 VEACLNKEPRFRPTAKELLKHKFI-----TRYTKKTSYLSELIDRYRR------WKSEGHGEESS 300

  Fly   319 GVPQRIASKMTSRTNGV--------PAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYID-- 373
            .....:..:...|..|.        |:..:.|..|::...  |:.|...:..|...||..:|.
Zfish   301 SDDSDMDGEGDDRDQGPMWTFPTVRPSTINKLNRGLSHLD--NKTSDVMKRQPKSSSLTSFITPI 363

  Fly   374 -EELK 377
             :|||
Zfish   364 FKELK 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	131/258 (51%)
		S_TKc	26..283	CDD:214567	131/257 (51%)
		CNH	869..1184	CDD:279162
stk25a	XP_005165982.1	STKc_MST3_like	20..291	CDD:270786	137/289 (47%)
stk25a	XP_005165982.1	S_TKc	20..270	CDD:214567	131/257 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910