DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hppy and msn

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_524679.3	Gene:	msn / 44030	FlyBaseID:	FBgn0010909	Length:	1504	Species:	Drosophila melanogaster

Alignment Length:	1483	Identity:	349/1483 - (23%)
Similarity:	548/1483 - (36%)	Gaps:	470/1483 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NANMLSSDISR-RNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEI 72
            |.::...|::. ::|...:|||:.:|:||||.|||.:..::.:||||||:.:...::.:|..:..
  Fly    14 NCSLDDIDLTALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEIN 78

  Fly    73 IMMRDCRHPNIIAYYGSYLRR------DKLWICMEFCGGGSLQDIYQVT--GPLTEVQIAYMCRE 129
            ::.:...|.||..|||:::::      |:||:.||:||.||:.|:.:.|  ..|.|..|||:|||
  Fly    79 VLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICRE 143

  Fly   130 TLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAA 194
            .|:||.||||...:||||||.|:|||:..:|||.|||||||:..||.:|.:||||||||||||.|
  Fly   144 ILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIA 208

  Fly   195 VERK--GGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFH 257
            .:..  ..|:...|:|:.||||:|:||.|||:.||||||||||:.::  .||.|.:| |||..||
  Fly   209 CDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIPRN--SPPRLKSK-KWSKKFH 270

  Fly   258 NFIKTALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKY--------QSPNPQFYYYL---- 310
            .||.|.|.|:..:||..|.||:|.|::.:.:.|..:..|:.:        |....:.|.|.
  Fly   271 GFIDTVLVKDYHQRPYTENLLKHGFIKDQPTDRQVRIQLKDHIDRCKKRKQEKEREDYRYSGSDN 335

  Fly   311 DGDEESVAGVPQRIASKM---TSRTN----------GVPAQNHTL-------------------- 342
            |.||..:||....|....   |.|.|          ....|.|.|
  Fly   336 DDDEPQLAGEHSSIVQAPGGDTLRRNFQQIQEGRLAAEQQQQHHLMAQAQAQAAAAHAAAQAQAQ 400

  Fly   343 -----------------------KTGMTTNSTWNERSSSPETLPSDMSL------------LQYI 372
                                   :......:...:.:..|:. ||...:            |..:
  Fly   401 LQQQQQQAAAAAAAAAHAAQQAQQAAQQAQAQQPQANRQPKP-PSRQQVEEPGPPARPPQRLIVV 464

  Fly   373 DEELKLRATLPLNNDTKDPLGAECSCSSHNG------------------GAAGGGG--------- 410
            .:.......||......:|.|........|.                  .||||.|
  Fly   465 PDPPHANRPLPPTPKCGEPAGQTPQQQQRNSQNNFKPSLPPRRPEPQPQTAAGGQGSQQQAQPEA 529

  Fly   411 -------GGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHP----NHLHQHQSHQLP 464
                   ..|:. .:||:|:.|..||...|.:      .||.:.|...|    :.|....|...|
  Fly   530 PPRNNRQSSGLS-SSGGSASGGGGSSKPAAAL------PQQSNNHLGQPVNPLDPLDSSDSDSEP 587

  Fly   465 QQQQQQSHQ-----------------AAQQEHHHHHPMT------------------------SS 488
            .:...::..                 ...::.:...|::                        :.
  Fly   588 DEPNDRARNDGTLLASDPPKPLPGLGPVSEDANTTTPLSHGSGGPPNRPLPPTPDDDDQAGDRTL 652

  Fly   489 ISSGLVTANANNISSSASLASMPGLSAYLGMRSHVV--------------GHMGMGFG-----MG 534
            |....:..|.|.:..|||.:......:..|..|:::              |..|.|.|     ..
  Fly   653 IMKRKLEQNINRLQKSASTSQANVTPSRRGDESNLLRDWDFDRFFPKNANGPRGSGRGSPTTTAS 717

  Fly   535 LGMSN-LRTTSIDADDDELVAAD----------------------VAMNNAAAAVPGNGSGAGNG 576
            |..|: |.|..:|........|:                      :|....:|:..|:|||:.:|
  Fly   718 LSRSSQLSTLKVDTKLQRASVAEAITRPVPRGYQPLKAEPSASQSIAKEQGSASGSGSGSGSASG 782

  Fly   577 SGSGCSASAAHYLRYSSNYR---------------------------SAAAAQASQAAHP----- 609
            ||||.|.::..:.|..|:.|                           |.|:|..|.|..|
  Fly   783 SGSGGSTNSPAHKRQDSDSRLPTNFERGFRRENSDFFPLAKRYSAVFSGASASGSTAGSPSAQAL 847

  Fly   610 ---------------HVNSNSNSNNGHGHAP-------ITSSI-----------------SSSAS 635
                           .::|.|..|:..| ||       .|:|.                 .:|.|
  Fly   848 QRSSAVYQRNSIYSSSISSKSKENDVPG-APGAAAAGTATASAKPGPAAATTTATKGAAPKTSKS 911

  Fly   636 SASFY---------NRLLLLDNSS------------------------------GDAVVGGNGGG 661
            .|:|:         ..:::|.|::                              |....||.|||
  Fly   912 LANFHFLRPRREKTESVIVLQNAAVRAQRLQQLQQQQQQQQLQQQQQQQNRGGGGGGGGGGGGGG 976

  Fly   662 SSNISSSGGASSGTNGLLDKHEL-DALPQAA-------TKSAGDGF----------SHSNSPTAN 708
            ||.:.:. |...||.|......| |.|.||:       .||:.:.:          :.|.|..|:
  Fly   977 SSGVGAD-GTGLGTPGTRTSSVLPDLLSQASPATPPRHDKSSSEEYQAAISSSVHSTPSKSFIAS 1040

  Fly   709 SGAGATG-----------SRDNDGPSS-----SNSSHLYQNLLRSSSGETPAGSS-------SAG 750
            ||:|..|           ...|..|.|     |:||:..||..::|..:|.:.||       ||.
  Fly  1041 SGSGGLGLGGGTVVGGVIISSNHSPQSTISLASSSSNSRQNSPKNSISKTRSSSSITNLLHKSAS 1105

  Fly   751 NNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRTRSLSDGGTQDDDEAEKEAQPDLLNN 815
            ::....|.........|....:.:......|:...:|..|.....||:   ..:.:|:..: :|.
  Fly  1106 SSSANLHHLTPCSSTSSASISNPLPPHAYALQQKQRSFLTFGFGAGGS---GPSRRESHVN-VNV 1166

  Fly   816 TPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKIFNGCPLRVHCTASWIHPETRDQHLLI 880
            ||     .||:..:           .||::..   :.|.||.   .:.|.|.|      ..:|||
  Fly  1167 TP-----TSHEAAN-----------DTPEIRK---YKKRFNS---EILCAALW------GVNLLI 1203

  Fly   881 GAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVI---KDVLMSLSGKSCQLYRHDLVALHSKQTVR 942
            |.|.|:..|:.:  ....:.||..||......:   :::|:::|||..::..:.|..|.||
  Fly  1204 GTENGLMLLDRS--GQGKVYQLISRRRFQQMEVLEGQNILVTISGKKNRVRVYYLSWLKSK---- 1262

  Fly   943 FSLHMNKIPERLVPRKFALTTKVPDTKCCTQCCVTRNPYNGYKYLCGATPSGIFLMQWY-DPLNK 1006
             .|..:.:.:::..|...:  .|.|.:......:.:  |...|:|..|....|.:..|. .|.:|
  Fly  1263 -ILRTDGLSDQVERRNGWI--NVGDLQGAVHFKIVK--YERIKFLVIALKDSIEIYAWAPKPYHK 1322

  Fly  1007 FMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMIITPELEY-PIVCTGVRKAMNGCLKLELINMNS 1070
            ||..|.                            ..|||: |::   |...:....:|::| ..|
  Fly  1323 FMAFKN----------------------------FGELEHRPLL---VDLTIEDQSRLKVI-YGS 1355

  Fly  1071 ASWFHSEDLE----YD------AMATMVPRRDLLKVVRVHQVEKDAILVCYGN 1113
            |..||:.||:    ||      ....::|.    .:|.:.......:|:||.|
  Fly  1356 AEGFHAVDLDSAEVYDIYLPKHTQGAIIPH----CIVALPNSNGMQLLLCYDN 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	129/267 (48%)
		S_TKc	26..283	CDD:214567	129/266 (48%)
		CNH	869..1184	CDD:279162	55/260 (21%)
msn	NP_524679.3	STKc_myosinIII_N_like	25..296	CDD:270785	130/273 (48%)
		S_TKc	32..296	CDD:214567	129/266 (48%)
		CNH	1183..1484	CDD:214481	61/278 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438535
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840