DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and MAP3K3

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_976226.1	Gene:	MAP3K3 / 4215	HGNCID:	6855	Length:	657	Species:	Homo sapiens

Alignment Length:	299	Identity:	96/299 - (32%)
Similarity:	155/299 - (51%)	Gaps:	25/299 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAAHSHHNANMLSSDISRRNPQD--EYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEP-- 61
            :.:|.|.:..::...::..::|..  .:...:.:|.|.:|.||....:.:....|.|.::.:|
Human   366 LRSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDS 430

  Fly    62 ---SDDIQIIQQEIIMMRDCRHPNIIAYYGSYLRRDK----LWICMEFCGGGSLQDIYQVTGPLT 119
               |.::..::.||.::::.:|..|:.|||..  ||:    |.|.||:..|||::|..:..|.||
Human   431 PETSKEVSALECEIQLLKNLQHERIVQYYGCL--RDRAEKTLTIFMEYMPGGSVKDQLKAYGALT 493

  Fly   120 EVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATI----NKRKS 180
            |.......|:.|:|:.||||...:||||||||||....|:|||.|||.|.:: .||    ...:|
Human   494 ESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL-QTICMSGTGMRS 557

  Fly   181 FIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPT 245
            ..||||||:|||.:.|   ||.:..|:|:.|.|.:|:...:||..:...|.|:|   |...:|..
Human   558 VTGTPYWMSPEVISGE---GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIF---KIATQPTN 616

  Fly   246 LNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQ 284
            .......|....:|::....: .::||:||.||.|.|.|
Human   617 PQLPSHISEHGRDFLRRIFVE-ARQRPSAEELLTHHFAQ 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	91/270 (34%)
		S_TKc	26..283	CDD:214567	91/269 (34%)
		CNH	869..1184	CDD:279162
MAP3K3	NP_976226.1	PB1_Mekk2_3	76..154	CDD:99726
MAP3K3	NP_976226.1	STKc_MEKK3_like	392..652	CDD:270795	91/269 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910