Protein Alignment hppy and GckIII

DIOPT Version :10

• Sequence 1: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Sequence 2: NP_650596.1
• Gene: GckIII / 42064
• FlyBaseID: FBgn0266465
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 210/689 - (30%)
• Similarity: 327/689 - (47%)
• Gaps: 112/689 - (16%)

  Fly    27 ELI----QKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPS-DDIQIIQQEIIMMRDCRHPNIIAY 86
            |||    ::||.|::|:|:|....::.::.|||:|.||.: |:|..|||||:::..|..|.:..|
  Fly    10 ELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQCDSPYVTKY 74

  Fly    87 YGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGAN 151
            |||:|:..||||.||:.||||..|:.: .|...|:.|..:.||.||||:||||..|:|||||.||
  Fly    75 YGSFLKGTKLWIIMEYLGGGSALDLMK-AGSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAAN 138

  Fly   152 ILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIE 216
            :||:|.||||||||||:.|:|.|.:||.:|:|||:||||||.   ::..|:...|||:.||||||
  Fly   139 VLLSEQGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVI---KQSQYDAKADIWSLGITAIE 200

  Fly   217 LAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHP 281
            ||:.:||..:|||||.|||:.|:  .||.|..  .::.:|.:|::..|.|:|:.||||:.||::|
  Fly   201 LAKGEPPNSELHPMRVLFLIPKN--NPPQLTG--SYTKSFKDFVEACLNKDPENRPTAKELLKYP 261

  Fly   282 FVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPAQNHTLKT-- 344
            |::.........:|:.:::.     :....|||.....  :...|...::..|.......:.|
  Fly   262 FIKKAKKNAYLIDLIDRFKK-----WKVSKGDESETES--ENSDSDSDAKQGGSSQDEPWIMTVK 319

  Fly   345 GMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHNGGAAGGG 409
            |:..|       |:|.   :.::..|..:.||.::   .|...|..|.|        .||.....
  Fly   320 GLHIN-------SAPR---AGVNSFQLQEHELTMQ---KLMQTTHSPAG--------GGGVQASP 363

  Fly   410 GGGGVGVGAGGAAANGSSSSSGGATVGTTHHQ---HQQHHQHHHHPNHLHQHQSHQLPQQQQQQS 471
            ....:.......||:.||.|...|..|.:...   .|..|.|:|:.|:::.:....|       |
  Fly   364 AANALSSSVSAVAASASSVSVITANEGVSSASALPPQNSHVHNHNHNNINNNNIRNL-------S 421

  Fly   472 HQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGFGMGLG 536
            ::.|.....:..|..||::|          |||||.......|:...:|
  Fly   422 NKHATTTMLNAAPPPSSVTS----------SSSASELQQKRSSSKPELR---------------- 460

  Fly   537 MSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYRSAAAA 601
             .:.....:|..:|...:..:.:.   ::||..            |.:.....|.||...|..|.
  Fly   461 -QSRSAAPLDQVEDRRASLGLPLQ---SSVPTP------------STAEQQQQRRSSQRESFHAN 509

  Fly   602 QASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSS----------GDAVVG 656
            .|:..|     |.|:|:|.|.|....::..:|....|...:.|:..||:          .|....
  Fly   510 NAALVA-----SCSSSSNNHSHEEHVATNHASHVKHSGAGQRLVQTNSACLNNFLFPVLSDIQRK 569

  Fly   657 GNGGGSSNISSSGGASSGTNGLLDKHELDALPQAATKSA 695
            .:||||:....|||.:.|...  |..:|.::.:.|.:|:
  Fly   570 YSGGGSAGSGGSGGRNIGVGS--DIGDLKSVFELAERSS 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	127/260 (49%)
		CNH	864..1193	CDD:470577
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	127/283 (45%)