DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hppy and myo3a

DIOPT Version :9

Sequence 1:	NP_725863.1	Gene:	hppy / 37203	FlyBaseID:	FBgn0263395	Length:	1218	Species:	Drosophila melanogaster
Sequence 2:	NP_991142.2	Gene:	myo3a / 402814	ZFINID:	ZDB-GENE-041026-4	Length:	1775	Species:	Danio rerio

Alignment Length:	391	Identity:	139/391 - (35%)
Similarity:	213/391 - (54%)	Gaps:	61/391 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEI-----IMMRDCRH 80
            :|.|.:|:|:.||.||||.|||.........||:|::     |.|..|.:||     |:.....|
Zfish    16 DPSDTWEIIETIGKGTYGKVYKVHNKVDGSKAAVKIL-----DPIHDIDEEIEAEYNILKALSDH 75

  Fly    81 PNIIAYYGSYLRR-----DKLWICMEFCGGGSLQDIYQVTGPL------TEVQIAYMCRETLKGL 134
            ||::.::|.:.::     |:||:.:|.|.|||:.|:  ..|.|      .|..||::..|.|.||
Zfish    76 PNVVKFFGMFYKKDVKTGDQLWLVLELCNGGSVTDL--AKGMLKRGDRMEEPIIAFILHEALMGL 138

  Fly   135 EYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERK- 198
            ::||....:|||:||.|||||..|.:||.|||||||:|.|..:|.:.:|||:||||||.|.|::
Zfish   139 QHLHVNKTIHRDVKGNNILLTTDGGIKLVDFGVSAQLTNTRLRRNTSVGTPFWMAPEVIACEQQL 203

  Fly   199 -GGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKT 262
             ..|::.||:|:.|||||||.:..||:.:||||||||.:.::  .||||:..:.||..|::||:.
Zfish   204 DSTYDERCDVWSLGITAIELGDGDPPLAELHPMRALFKIPRN--PPPTLHQPELWSNDFNDFIRK 266

  Fly   263 ALTKNPKKRPTAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEE-------SVAGV 320
            .|.|:.:.||....||||.|:         |:::.:.::...|....:|.:::       |:.|.
Zfish   267 CLIKDFELRPNVLDLLQHVFI---------KQIVGREKTLQKQLMELIDLNQQMGIIEKTSLLGK 322

  Fly   321 PQRIASKMTSRTNGVPAQNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYID-----EELKLRA 380
            ..|.:.....|.       ||.|     ||....:|.:.:. ..|::.|:.:|     |:|:.|.
Zfish   323 SDRDSDSRHERI-------HTKK-----NSYMKSQSQTCDD-ADDLATLEVLDENTITEQLQRRY 374

  Fly   381 T 381
            |
Zfish   375 T 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	116/275 (42%)
		S_TKc	26..283	CDD:214567	116/274 (42%)
		CNH	869..1184	CDD:279162
myo3a	NP_991142.2	PKc_like	2..287	CDD:328722	118/279 (42%)
myo3a	NP_991142.2	MYSc_Myo3	364..1091	CDD:276830	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910